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The protein encoded by ELAVL2 is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. Additionally we are shipping ELAVL2 Antibodies (79) and ELAVL2 Kits (1) and many more products for this protein.
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ELAVL2-regulated co-expression networks are also enriched for neurodevelopmental and synaptic genes, and include genes with human-specific patterns of expression in the frontal pole. Together, these data suggest that ELAVL2 regulation of transcript expression is critical for neuronal function and clinically relevant to autism
Tests for gene-environment interaction between these 33 genes and maternal smoking found evidence for interaction with two additional genes: GRID2 (show GRID2 Proteins) and ELAVL2 among European mothers
the mutually antagonistic action of two RNA-binding proteins, Hu and hnRNP K (show HNRNPK Proteins), control the timing of the switch from proliferation to neuronal differentiation through the post-transcriptional regulation of p21 (show CDKN1A Proteins) mRNA
ELAVL2 has an ambivalent role in oocytes: it functions as a pleiotropic translational repressor in efficient production of grown oocytes, while its disposal during the NSN/SN transition contributes to the acquisition of full developmental competence.
The predominant expression of REST4, HuB/C/D and nPTB (show PTBP2 Proteins) in post-mitotic fiber cells, together with miR (show MLXIP Proteins)-124 expression in vertebrate lenses, was shown.
the mutually antagonistic action of two RNA-binding proteins, Hu and hnRNP K (show HNRNPK Proteins), control the timing of the switch from proliferation to neuronal differentiation through the post-transcriptional regulation of p21 mRNA
elrB expression was not detected in Xenopus retina ganglion cell layer until stage 32.
direct correlation between ElrB binding and translational repression by the Vg1 3'-UTR
Data show that, while ElrA and ElrB are 69% identical and both exhibit RNA binding in the nM range, recombinant ElrB, but not ElrA, is able to oligomerise.
Report on the identification of Xenopus ElrA/B proteins and show that Elr-type proteins are part of one RNP (show RNPC3 Proteins) complex together with other localization proteins from Xenopus oocytes.
The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene.
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
, ELAV-like neuronal protein 1
, ELAV-like protein 2
, hu-antigen B
, nervous system-specific RNA-binding protein Hel-N1
, ELAV-like 2
, HU-antigen B
, nervous system-specific RNA-binding protein Mel-N1
, RNA binding protein HuB
, embryonic lethal, abnormal vision-like 2
, Elav like-1
, Protein ElrB