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Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA (By similarity). Additionally we are shipping ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 (Hu Antigen D) Proteins (8) and many more products for this protein.
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The high titres of HuD in SCLC patients and preferable consistency suggested that HuD may serve as a potential diagnostic criterium for SCLC and may serve as a marker of disease progression.
HuD binds to the APP (show APP Antibodies) and BACE1 (show BACE Antibodies) 3' UTRs and increases APP (show APP Antibodies) and BACE1 (show BACE Antibodies) levels.
study showed HuD is associated with histological grade, iffuse invasion and nodal metastasis in oral squamous cell carcinoma; it regulates expression of VEGF-A (show VEGFA Antibodies), VEGF-D (show Figf Antibodies), MMP-2 (show MMP2 Antibodies) and MMP-9 (show MMP9 Antibodies)
Phosphomimetic mutation at position Ser (show SIGLEC1 Antibodies) 221 increased nuclear HUD export.
Alzheimer's disease brain tissues with elevated neuroserpin (show SERPINI1 Antibodies) protein also showed increased expression of THRbeta1 and HuD
found that p97 (show EIF4G2 Antibodies) and its cofactor, UBXD8 (show FAF2 Antibodies), destabilize p21 (show CDKN1A Antibodies), MKP-1 (show DUSP1 Antibodies), and SIRT1 (show SIRT1 Antibodies), three established mRNA targets of the RNA-binding protein (show PTBP1 Antibodies) HuR (show ELAVL1 Antibodies), by promoting release of HuR (show ELAVL1 Antibodies) from mRNA
HuD is a pivotal regulator of insulin translation in pancreatic beta cells.
the endogenous function of ELAVL4 in relation to radiation sensitivity might be the regulation of cell proliferation and death
Complexes of HuD and Tax (show CNTN2 Antibodies) epitopes with HLA-A2 are close but imperfect structural mimics: alphabeta T-cell receptor with self antigens is driven to engage HuD in the same traditional binding mode as Tax (show CNTN2 Antibodies).
HuD stabilizes the GAP-43 (show GAP43 Antibodies) mRNA through a mechanism that is dependent on the length of the poly(A) tail and involves changes in its affinity for the mRNA
Study showed that BDNF (show BDNF Antibodies) promotes regeneration induced by spared nerve injury, involving the GAP-43 (show GAP43 Antibodies) and NFH (show NEFH Antibodies) modulation under the stabilizing activity of HuD.
our results indicate that HuD functions as a novel repressor of lipid synthesis in pancreatic b cells.
Data show that RNA binding protein HuD and special adenine-thymine (AT)-rich DNA-binding protein 1 (SATB1) form a positive regulatory loop that enhances NeuroD1 protein transcription and subsequent neuronal differentiation.
a direct effect of HuD on regulating translation of dendritic Bdnf (show BDNF Antibodies) mRNAs
HuD splice variants might play a role in controlling the timing of proliferation/differentiation switching by controlling the translation and alternative splicing of target genes.
Antiretroviral drugs may recruit the HuD-GAP43 (show GAP43 Antibodies) pathway, potentially contributing to a response to the antiretroviral neuronal toxicity.
HuD protein is necessary for the establishment of neocortical and hippocampal circuitry and their function.
HuD to be an inducer of ATG5 expression and hence a critical regulator of autophagosome formation in pancreatic beta cells.
HuD promotes BDNF (show BDNF Antibodies) expression in brain neurons via selective stabilization of the BDNF (show BDNF Antibodies) long 3'UTR (show UTS2R Antibodies) mRNA.
HuD controls insulin II translation
Data show that the two elrD transcripts, elrD1 and elrD2, present the same tissue-specific pattern of expression, with distinct developmental regulation.
elrD expression was detected in developing Xenopus retina from stage 26 onwards in the differentiating ganglion cell layer.
Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA (By similarity). May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR.
ELAV-like protein 4
, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
, Embryonic lethal, abnormal vision, Drosophila, homolog of, like-4
, Hu antigen D
, hu-antigen D
, paraneoplastic encephalomyelitis antigen HuD
, elav-related D
, embryonic lethal, abnormal vision-related D
, RNA-binding protein HuD
, ELAV-like 4
, HU-antigen D
, RNA-binding protein HUD3
, ELAV (embryonic lethal, abnormal vision)-like 4 (Hu antigen D)
, Protein ElrD
, embryonic lethal, abnormal vision, Drosophila)-like 4