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ELK4 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Additionally we are shipping ELK4, ETS-Domain Protein (SRF Accessory Protein 1) Proteins (6) and many more products for this protein.
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Data suggest that SIRT7 (show SIRT7 Antibodies) undergoes Lys (show LYZ Antibodies)-63 polyubiquitination, later removed by USP7 (show USP7 Antibodies) to repress enzymatic activity of SIRT7 (show SIRT7 Antibodies); USP7 (show USP7 Antibodies) and SIRT7 (show SIRT7 Antibodies) regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC (show G6PC Antibodies)); SIRT7 (show SIRT7 Antibodies) targets G6PC (show G6PC Antibodies) promoter through ELK4. (SIRT7 (show SIRT7 Antibodies) = sirtuin 7 (show SIRT7 Antibodies); USP7 (show USP7 Antibodies) = ubiquitin specific peptidase 7 (show USP7 Antibodies); G6PC (show G6PC Antibodies) = glucose-6-phosphatase catalytic subunit (show G6PC Antibodies); ELK4 = transcription factor ELK4)
SLC45A3-ELK4 may represent the first description of a recurrent RNA chimaeric transcript specific to prostate cancer that does not have a detectable DNA aberration
ELK4 is overexpressed in melanoma and knocking down the ELK4 or CDK2 (show CDK2 Antibodies) expression significantly attenuated the malignant phenotype of melanoma cells
CTCF (show CTCF Antibodies) has a role in regulating SLC45A3-ELK4 Chimeric RNA
Data suggest that chimeric SLC45A3-ELK4 controls prostate cancer cell proliferation, and the chimera level correlates with prostate cancer disease progression.
Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex
ELK4 is a direct androgen receptor (show AR Antibodies) target in prostate cancer cells. Androgens may thus contribute to the growth of prostate cancer via influencing ELK4 levels
Dok-4 (show DOK4 Antibodies) can target Elk-4 activity through multiple mechanisms, including binding of the transactivation domain, nuclear exclusion and protein destabilization.
MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.
Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1.
SAP-1 is required for Erk (show EPHB2 Antibodies)-mediated transcriptional events in thymocyte development.
T cell positive selection, and ERK (show EPHB2 Antibodies) signaling to SAP-1 is not required for the suppressive activity of T(reg (show KCNH2 Antibodies)) cells.
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.
ETS domain-containing protein Elk-4
, serum response factor accessory protein 1
, ELK4, member of ETS oncogene family
, SRF accessory protein 1
, proactivator polypeptide
, prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)
, clathrin-associated protein 1A
, sodium channel Nav1.8-binding protein
, sodium channel associated protein 1
, sodium channel-associated protein 1