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Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. Additionally we are shipping EDEM1 Proteins (5) and many more products for this protein.
Showing 10 out of 14 products:
Human Polyclonal EDEM1 Primary Antibody for IHC - ABIN966027
Nagase, Seki, Ishikawa, Ohira, Kawarabayasi, Ohara, Tanaka, Kotani, Miyajima, Nomura: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. in DNA research : an international journal for rapid publication of reports on genes and genomes 1997
Show all 2 references for ABIN966027
Chicken Polyclonal EDEM1 Primary Antibody for WB - ABIN2782826
Zuber, Cormier, Guhl, Santimaria, Hebert, Roth: EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites. in Proceedings of the National Academy of Sciences of the United States of America 2007
EDEM1 colocalizes with the selective autophagy cargo receptors p62/SQSTM1 (show SQSTM1 Antibodies), neighbor of BRCA1 gene 1 (NBR1 (show NBR1 Antibodies)) and autophagy-linked FYVE (Alfy (show WDFY3 Antibodies)) protein, and becomes engulfed by autophagic isolation membranes.
Endoplasmic reticulum degradation-enhancing alpha-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation.
miR (show MLXIP Antibodies)-581 promotes hepatitis B virus surface antigen expression by targeting Dicer (show DICER1 Antibodies) and EDEM1 in HepG2 cells.
EDEM1 associates with lifespan in animal models, although not humans.
analysis of a shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins
Tyrosinase (show TYR Antibodies) degradation is prevented when EDEM1 lacks the intrinsically disordered region
we suggest that a nascent glycoprotein can normally dissociate from EDEM1 and be rescued from endoplasmic reticulum associated degradation by reentering calnexin (show CANX Antibodies)-refolding cycles
signal sequence cleavage functionally regulated the association of EDEM1-soluble and membrane-integrated isoforms with distinct ERAD machinery and substrates.
EDEM1 protein recognition may be determined by the structure of the endoplasmic reticulum-associated protein degradation substrate in a study of mutant ricin A-chain transport to the cytosol.
mannose trimming enables delivery of a substrate glycoprotein from EDEM1 to late endoplasmic reticulum degredation steps through association with XTP3-B (show ERLEC1 Antibodies)
Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3 (show MAP1LC3A Antibodies)-I- and EDEM1-containing membranes
Data suggest Edem1/Edem2 (show EDEM2 Antibodies) participate in ricin translocation; overexpression of Edem2 (show EDEM2 Antibodies), in contrast to Edem1, promotes ricin subunit A transport from endoplasmic reticulum (ER) to cytosol; transport of ricin P250A mutant is Edem1/Edem2 (show EDEM2 Antibodies)-independent.
role of the lectins Htm1p/EDEM in the degradation process of CFTR (show CFTR Antibodies)
EDEM has a role in maintenance of protein folding efficiency and secretory capacity
EDEM is involved in retrotranslocation of ricin from the ER to the cytosol.
Cells with defective EDEM1 turnover contain unphysiologically high levels of EDEM1, show enhanced ER associated degradation activity and are characterized by impaired capacity to efficiently complete maturation of model glycopolypeptides.
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity.
ER degradation-enhancing alpha-mannosidase-like 1
, ER degradation enhancer, mannosidase alpha-like 1
, ER degradation-enhancing alpha-mannosidase-like 1-like
, ER degradation-enhancing alpha-mannosidase-like protein 1
, ER degradation ER degradation enhancer, mannosidase alpha-like 1