anti-Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Antibodies

The protein encoded by ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. Additionally we are shipping ENPP2 Kits (22) and ENPP2 Proteins (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ENPP2 5168 Q13822
ENPP2 18606 Q9R1E6
ENPP2 84050 Q64610
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Top anti-ENPP2 Antibodies at antibodies-online.com

Showing 10 out of 119 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of anti-ENPP2 Antibody (Center K416) (ABIN389374) in Y79 cell line lysates (35 µg/lane).ENPP2(arrow) was detected using the purified polyclonal antibody. Western blot analysis of anti-ENPP2 Antibody (Center K416) (ABIN389374) in mouse cerebellum tissue lysates (35 µg/lane).ENPP2(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of ENPP2 Antibody (Center) (ABIN650746) in mouse cerebellum tissue lysates (35 µg/lane). ENPP2 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of ENPP2 (arrow) using rabbit polyclonal ENPP2 Antibody (Center) (ABIN650746). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the ENPP2 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB (LEFT) Western blot analysis of ENPP2 Antibody (Center) in mouse cerebellum tissue lysates (35ug/lane). ENPP2 (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of ENPP2 (arrow) using rabbit polyclonal ENPP2 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ENPP2 gene (Lane 2) (Origene Technologies). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ENPP2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: COLO205 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$544.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$175.80
Details
Mouse Rabbit Un-conjugated ELISA   100 μg Log in to see 20 to 21 Days
$218.90
Details
Human Rabbit Un-conjugated ICC, IF, WB Western Blot: ENPP-2/Autotaxin Antibody [NBP1-32162] - 50 ug mouse brain lysate/extract 7. 5 % SDS-PAGE gel, antibody dilution 1:1000. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colorectal cancer labeled with Anti-Anei-ATX/Autotaxin Polyclonal Antibody, Unconjugated (ABIN740265) followed by conjugation to the secondary antibody Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-Anei-ATX/Autotaxin Polyclonal Antibody, Unconjugated (ABIN740265) at 1:200 followed by conjugation to the secondary antibody 100 μL Log in to see 3 to 7 Days
$295.90
Details

ENPP2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ENPP2 Antibodies

  1. Human Polyclonal ENPP2 Primary Antibody for EIA, WB - ABIN358034 : Kawagoe, Soma, Goji, Nishimura, Narita, Inazawa, Nakamura, Sano: Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2). in Genomics 1996 (PubMed)
    Show all 3 references for 358034

  2. Human Polyclonal ENPP2 Primary Antibody for EIA, WB - ABIN453640 : Nam, Clair, Kim, McMarlin, Schiffmann, Liotta, Stracke: Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor. in Cancer research 2001 (PubMed)
    Show all 3 references for 453640

  3. Mouse (Murine) Polyclonal ENPP2 Primary Antibody for ELISA - ABIN2001293 : Boucher, Quilliot, Pradères, Simon, Grès, Guigné, Prévot, Ferry, Boutin, Carpéné, Valet, Saulnier-Blache: Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. in Diabetologia 2005 (PubMed)
    Show all 2 references for 2001293

  4. Human Polyclonal ENPP2 Primary Antibody for EIA, WB - ABIN265084 : Murata, Lee, Clair, Krutzsch, Arestad, Sobel, Liotta, Stracke: cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases. in The Journal of biological chemistry 1994 (PubMed)
    Show all 2 references for 265084

More Antibodies against ENPP2 Interaction Partners

Xenopus laevis Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. Defects in forebrain development during loss-of-function experiments for ENPP2, an enzyme involved in the synthesis of extracellular lysophosphatidic acid.

Human Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. These findings suggest that the promoter hypomethylation and overexpression of ATX might play a contributory role in the pathogenesis of liver fibrosis in biliary atresia.

  2. LPA2 mRNA levels were associated with poorer differentiation, and higher LPA6 levels were associated with microvascular invasion in HCC; both became a risk factor for recurrence after surgical treatment when combined with increased serum ATX levels

  3. AKT (show AKT1 Antibodies) signaling played a role in ATX secretion regulation to facilitate ATX ER export by enhancing the nuclear factor of activated T cell (show NFATC3 Antibodies)-mediated p23 (Sec24C (show SEC24C Antibodies)) expression

  4. Expression of both ATX and IL-6 was increased in systemic scleroderma (SSc) skin, and lysophosphatidic acid-induced IL-6 levels and IL (show CYP11A1 Antibodies)-6-induced ATX levels were increased i (show CYP11A1 Antibodies)n fibroblasts from SSc patients compared with (show IL6 Antibodies) controls.

  5. Elevated levels of autotaxin and soluble markers of immune activation during HCV infection.

  6. These results suggest that the post-transcriptional regulation of ATX expression by HuR (show ELAVL1 Antibodies) and AUF1 (show HNRNPD Antibodies) modulates cancer cell migration.

  7. ATX is highly expressed in renal cell carcinoma (show MOK Antibodies) and bladder carcinoma.

  8. With a deeper understanding of the critical role of the autotaxin/lysophosphatidate axis in pancreatic cancer, targeting autotaxin or lysophosphatidate receptor may be a potential and promising strategy for cancer therapy.

  9. Plasma ATX activity is strongly associated with pruritus in primary biliary cholangitis, authors review the biochemistry of ATX and the rationale for its role in pruritus. [Review]

  10. Data suggest serum ATX levels correlate with presence/intensity of pruritus in pediatric cholestatic disorders; despite therapy, ATX is up-regulated in children with severe pruritus due to cholestatic disorders (AGS (show JAG1 Antibodies), Alagille syndrome; BA, biliary atresia; progressive familial intrahepatic cholestasis) compared to children with cholestatic disorders without pruritus (BASD, bile acid synthesis defects). [PILOT PROJECT]

Mouse (Murine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. This study showed that alternative autotaxin-independent pathways are likely responsible for local generation of lysophosphatidic acid in the injured lung.

  2. Hepatocyte autotaxin expression promotes liver fibrosis and liver cancer.

  3. These results indicate that ATX-lysophosphatidic acid-LPA3 (show LPAR3 Antibodies) signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF (show HBEGF Antibodies) and COX-2 (show COX2 Antibodies) pathways.

  4. ATX is required for the development and maintenance of dermal fibrosis in a mouse model of bleomycin-induced systemic scleroderma (SSc (show CYP11A1 Antibodies)) and enables 2 major mediators of SSc (show CYP11A1 Antibodies) fibrogenesis, lysophosphatidic acid and IL-6 (show IL6 Antibodies), to amplify the production of each other.

  5. These results suggest that the post-transcriptional regulation of ATX expression by HuR (show ELAVL1 Antibodies) and AUF1 (show HNRNPD Antibodies) modulates cancer cell migration.

  6. inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.

  7. findings indicate that the ATX level must be carefully regulated to ensure coordinated vascular formation

  8. Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer

  9. These findings identify ATX and LPA2 (show LPAR2 Antibodies) as radiation-regulated genes that appear to play a physiological role in DNA repair.

  10. The results are discussed in terms of ATX regulation in wound healing and cancer.We, therefore, demonstrate the concept that accumulation of LPA in the circulation decreases ATX production

Pig (Porcine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. ENPP2 may play an important role in the establishment of pregnancy in pigs by regulating lysophosphatidic acid production at the maternal-conceptus interface.

Cow (Bovine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.

ENPP2 Antigen Profile

Protein Summary

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with ENPP2

  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) antibody
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (enpp2) antibody
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2) antibody
  • ATX antibody
  • ATX-X antibody
  • AUTOTAXIN antibody
  • LysoPLD antibody
  • MGC132047 antibody
  • NPP2 antibody
  • Npps2 antibody
  • PD-Ialpha antibody
  • Pdnp2 antibody
  • zgc:63550 antibody

Protein level used designations for ENPP2

autotaxin , ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) , ectonucleotide pyrophosphatase/phosphodiesterase 2 , ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein , ectonucleotide pyrophosphatase/phosphodiesterase family member 2 , E-NPP 2 , autotaxin-t , extracellular lysophospholipase D , phosphodiesterase I/nucleotide pyrophosphatase 2 , plasma lysophospholipase D , lysoPLD , phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin) , atx

GENE ID SPECIES
100057101 Equus caballus
464353 Pan troglodytes
548690 Xenopus (Silurana) tropicalis
705287 Macaca mulatta
735240 Xenopus laevis
100173553 Pongo abelii
100219257 Taeniopygia guttata
5168 Homo sapiens
18606 Mus musculus
84050 Rattus norvegicus
393575 Danio rerio
420361 Gallus gallus
482026 Canis lupus familiaris
503658 Sus scrofa
532663 Bos taurus
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