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The protein encoded by ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. Additionally we are shipping ENPP2 Kits (22) and ENPP2 Proteins (14) and many more products for this protein.
Showing 10 out of 119 products:
Human Polyclonal ENPP2 Primary Antibody for EIA, WB - ABIN358034
Kawagoe, Soma, Goji, Nishimura, Narita, Inazawa, Nakamura, Sano: Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2). in Genomics 1996
Show all 3 references for 358034
Human Polyclonal ENPP2 Primary Antibody for EIA, WB - ABIN453640
Nam, Clair, Kim, McMarlin, Schiffmann, Liotta, Stracke: Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor. in Cancer research 2001
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Mouse (Murine) Polyclonal ENPP2 Primary Antibody for ELISA - ABIN2001293
Boucher, Quilliot, Pradères, Simon, Grès, Guigné, Prévot, Ferry, Boutin, Carpéné, Valet, Saulnier-Blache: Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. in Diabetologia 2005
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Human Polyclonal ENPP2 Primary Antibody for EIA, WB - ABIN265084
Murata, Lee, Clair, Krutzsch, Arestad, Sobel, Liotta, Stracke: cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases. in The Journal of biological chemistry 1994
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Defects in forebrain development during loss-of-function experiments for ENPP2, an enzyme involved in the synthesis of extracellular lysophosphatidic acid.
These findings suggest that the promoter hypomethylation and overexpression of ATX might play a contributory role in the pathogenesis of liver fibrosis in biliary atresia.
LPA2 mRNA levels were associated with poorer differentiation, and higher LPA6 levels were associated with microvascular invasion in HCC; both became a risk factor for recurrence after surgical treatment when combined with increased serum ATX levels
AKT (show AKT1 Antibodies) signaling played a role in ATX secretion regulation to facilitate ATX ER export by enhancing the nuclear factor of activated T cell (show NFATC3 Antibodies)-mediated p23 (Sec24C (show SEC24C Antibodies)) expression
Expression of both ATX and IL-6 was increased in systemic scleroderma (SSc) skin, and lysophosphatidic acid-induced IL-6 levels and IL (show CYP11A1 Antibodies)-6-induced ATX levels were increased i (show CYP11A1 Antibodies)n fibroblasts from SSc patients compared with (show IL6 Antibodies) controls.
Elevated levels of autotaxin and soluble markers of immune activation during HCV infection.
These results suggest that the post-transcriptional regulation of ATX expression by HuR (show ELAVL1 Antibodies) and AUF1 (show HNRNPD Antibodies) modulates cancer cell migration.
ATX is highly expressed in renal cell carcinoma (show MOK Antibodies) and bladder carcinoma.
With a deeper understanding of the critical role of the autotaxin/lysophosphatidate axis in pancreatic cancer, targeting autotaxin or lysophosphatidate receptor may be a potential and promising strategy for cancer therapy.
Plasma ATX activity is strongly associated with pruritus in primary biliary cholangitis, authors review the biochemistry of ATX and the rationale for its role in pruritus. [Review]
Data suggest serum ATX levels correlate with presence/intensity of pruritus in pediatric cholestatic disorders; despite therapy, ATX is up-regulated in children with severe pruritus due to cholestatic disorders (AGS (show JAG1 Antibodies), Alagille syndrome; BA, biliary atresia; progressive familial intrahepatic cholestasis) compared to children with cholestatic disorders without pruritus (BASD, bile acid synthesis defects). [PILOT PROJECT]
This study showed that alternative autotaxin-independent pathways are likely responsible for local generation of lysophosphatidic acid in the injured lung.
Hepatocyte autotaxin expression promotes liver fibrosis and liver cancer.
These results indicate that ATX-lysophosphatidic acid-LPA3 (show LPAR3 Antibodies) signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF (show HBEGF Antibodies) and COX-2 (show COX2 Antibodies) pathways.
ATX is required for the development and maintenance of dermal fibrosis in a mouse model of bleomycin-induced systemic scleroderma (SSc (show CYP11A1 Antibodies)) and enables 2 major mediators of SSc (show CYP11A1 Antibodies) fibrogenesis, lysophosphatidic acid and IL-6 (show IL6 Antibodies), to amplify the production of each other.
inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.
findings indicate that the ATX level must be carefully regulated to ensure coordinated vascular formation
Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer
These findings identify ATX and LPA2 (show LPAR2 Antibodies) as radiation-regulated genes that appear to play a physiological role in DNA repair.
The results are discussed in terms of ATX regulation in wound healing and cancer.We, therefore, demonstrate the concept that accumulation of LPA in the circulation decreases ATX production
ENPP2 may play an important role in the establishment of pregnancy in pigs by regulating lysophosphatidic acid production at the maternal-conceptus interface.
These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
, ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
, ectonucleotide pyrophosphatase/phosphodiesterase 2
, ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein
, ectonucleotide pyrophosphatase/phosphodiesterase family member 2
, E-NPP 2
, extracellular lysophospholipase D
, phosphodiesterase I/nucleotide pyrophosphatase 2
, plasma lysophospholipase D
, phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin)