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The protein encoded by ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. Additionally we are shipping ENPP2 Antibodies (119) and ENPP2 Proteins (14) and many more products for this protein.
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Defects in forebrain development during loss-of-function experiments for ENPP2, an enzyme involved in the synthesis of extracellular lysophosphatidic acid.
The effects of gamma radiation on mRNA levels of autotaxin and 14 inflammatory mediators in adipose tissue and the consequences for radiation therapy and chemotherapy are discussed.
These findings suggest that the promoter hypomethylation and overexpression of ATX might play a contributory role in the pathogenesis of liver fibrosis in biliary atresia.
LPA2 mRNA levels were associated with poorer differentiation, and higher LPA6 levels were associated with microvascular invasion in HCC; both became a risk factor for recurrence after surgical treatment when combined with increased serum ATX levels
AKT signaling played a role in ATX secretion regulation to facilitate ATX ER export by enhancing the nuclear factor of activated T cell-mediated p23 (Sec24C) expression
Expression of both ATX and IL-6 was increased in systemic scleroderma (SSc) skin, and lysophosphatidic acid-induced IL-6 levels and IL (show CYP11A1 ELISA Kits)-6-induced ATX levels were increased i (show CYP11A1 ELISA Kits)n fibroblasts from SSc patients compared with (show IL6 ELISA Kits) controls.
Elevated levels of autotaxin and soluble markers of immune activation during HCV infection.
These results suggest that the post-transcriptional regulation of ATX expression by HuR (show ELAVL1 ELISA Kits) and AUF1 (show HNRNPD ELISA Kits) modulates cancer cell migration.
ATX is highly expressed in renal cell carcinoma and bladder carcinoma.
With a deeper understanding of the critical role of the autotaxin/lysophosphatidate axis in pancreatic cancer, targeting autotaxin or lysophosphatidate receptor may be a potential and promising strategy for cancer therapy.
Plasma ATX activity is strongly associated with pruritus in primary biliary cholangitis, authors review the biochemistry of ATX and the rationale for its role in pruritus. [Review]
ENPP2 links Activin-A (show INHBA ELISA Kits) enhanced mTOR (show FRAP1 ELISA Kits) signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
This study showed that alternative autotaxin-independent pathways are likely responsible for local generation of lysophosphatidic acid in the injured lung.
Hepatocyte autotaxin expression promotes liver fibrosis and liver cancer.
These results indicate that ATX-lysophosphatidic acid-LPA3 (show LPAR3 ELISA Kits) signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF (show HBEGF ELISA Kits) and COX-2 (show COX2 ELISA Kits) pathways.
ATX is required for the development and maintenance of dermal fibrosis in a mouse model of bleomycin-induced systemic scleroderma (SSc (show CYP11A1 ELISA Kits)) and enables 2 major mediators of SSc (show CYP11A1 ELISA Kits) fibrogenesis, lysophosphatidic acid and IL-6 (show IL6 ELISA Kits), to amplify the production of each other.
inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.
findings indicate that the ATX level must be carefully regulated to ensure coordinated vascular formation
Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer
These findings identify ATX and LPA2 (show LPAR2 ELISA Kits) as radiation-regulated genes that appear to play a physiological role in DNA repair.
ENPP2 may play an important role in the establishment of pregnancy in pigs by regulating lysophosphatidic acid production at the maternal-conceptus interface.
These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
, ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
, ectonucleotide pyrophosphatase/phosphodiesterase 2
, ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein
, ectonucleotide pyrophosphatase/phosphodiesterase family member 2
, E-NPP 2
, extracellular lysophospholipase D
, phosphodiesterase I/nucleotide pyrophosphatase 2
, plasma lysophospholipase D
, phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin)