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anti-Egl Nine Homolog 1 (C. Elegans) (EGLN1) Antibodies

The protein encoded by EGLN1 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Additionally we are shipping Egl Nine Homolog 1 (C. Elegans) Kits (6) and Egl Nine Homolog 1 (C. Elegans) Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EGLN1 112405 Q91YE3
EGLN1 308913  
EGLN1 54583 Q9GZT9
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Top anti-Egl Nine Homolog 1 (C. Elegans) Antibodies at antibodies-online.com

Showing 10 out of 148 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-EGLN1 Antibody Titration: 1.25ug/mlELISA Titer: 1:12500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated EIA, IF, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (35.35 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated WB EGLN1 Antibody (C-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the EGLN1 antibody detected the EGLN1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 2 to 3 Days
$378.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human kidney labeled with Anti-PHD2 Polyclonal Antibody, Unconjugated (ABIN702640) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse embryo labeled with Anti-PHD2 Polyclonal Antibody, Unconjugated (ABIN702640) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Dog Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Mouse HRP IHC (p), WB   100 μg Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details

EGLN1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Egl Nine Homolog 1 (C. Elegans) Antibodies

  1. Human Polyclonal EGLN1 Primary Antibody for ELISA, WB - ABIN565755 : Aprelikova, Pandolfi, Tackett, Ferreira, Salnikow, Ward, Risinger, Barrett, Niederhuber: Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. in Cancer research 2009 (PubMed)

  2. Dog (Canine) Polyclonal EGLN1 Primary Antibody for WB - ABIN2775907 : Appelhoff, Tian, Raval, Turley, Harris, Pugh, Ratcliffe, Gleadle: Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against Egl Nine Homolog 1 (C. Elegans) Interaction Partners

Xenopus laevis Egl Nine Homolog 1 (C. Elegans) (EGLN1) interaction partners

  1. comparative analysis of phd1 (show EGLN2 Antibodies), 2, and 3 expression in Xenopus laevis

Mouse (Murine) Egl Nine Homolog 1 (C. Elegans) (EGLN1) interaction partners

  1. Stabilized HIF-1alpha (show HIF1A Antibodies) induced by PHD2 conditional knockout resulted in the transition of muscle fibers toward a slow fiber type via a calcineurin (show PPP3CA Antibodies)/NFATc1 (show NFATC1 Antibodies) signaling pathway.

  2. HIF-P4H-2 inhibition may be a novel strategy for protecting against the development of atherosclerosis.

  3. findings show hypoxia and loss of PHD2 revert cancer-associated fibroblast (CAF (show LAMA2 Antibodies)) activation; this reversion is associated with loss of matrix stiffening and consequently reduction in spontaneous metastases to lungs and liver

  4. Data (including data from studies in transgenic/knockout mice) suggest that expression of Phd2/Egln1 in chondrocytes plays key role in chondrogenesis, osteogenesis, and developmental gene expression regulation.

  5. a genetic link between EGLN1 and VWF (show VWF Antibodies) in a constitution specific manner which could modulate thrombosis/bleeding susceptibility and outcomes of hypoxia, is reported.

  6. PHD2 in the liver has a role in survival in lactic acidosis by activating the Cori cycle

  7. Regulatory link was discovered between mitochondrial Txnrd and the JNK (show MAPK8 Antibodies)-PHD2-Hif-1alpha (show HIF1A Antibodies) axis, which highlights how the loss of Txnrd2 (show TXNRD2 Antibodies) and the resulting altered mitochondrial redox balance impairs tumor growth as well as tumor-related angiogenesis.

  8. combined deletion of Phd2 and Phd3 (show EGLN3 Antibodies) dramatically decreased expression of phospholamban (PLN (show PLN Antibodies)), resulted in sustained activation of calcium/calmodulin (show Calm2 Antibodies)-activated kinase II (CaMKII (show CAMK2G Antibodies)), and sensitized mice to chronic beta-adrenergic stress-induced myocardial injury

  9. PHD2 activity is a critical contributor to the high fat-diet-induced cardiac dysfunction.

  10. Phd2 plays an important role in regulating bone formation in part by modulating expression of Osx (show SP7 Antibodies) and bone formation marker genes.

Human Egl Nine Homolog 1 (C. Elegans) (EGLN1) interaction partners

  1. The present study demonstrated that the antiapoptotic effect of TMP in CoCl2-induced HUVECs was, at least in part, via the regulation of the PHD2/HIF-1alpha (show HIF1A Antibodies) signaling pathway.

  2. the levels of both miR (show MLXIP Antibodies)-182 and HIF1alpha (show HIF1A Antibodies) were elevated, while the expression PHD2 and FIH1 (show HIF1AN Antibodies) was downregulated in a mouse model of prostate cancer.

  3. findings show hypoxia and loss of PHD2 revert cancer-associated fibroblast (CAF (show KAT2B Antibodies)) activation

  4. In this article, UTMD/PEI mediated gene transfection was investigated and the US parameters were optimized. Furthermore, the biological effects of PHD2 shRNA were investigated in H9C2 cells.

  5. a genetic link between EGLN1 and VWF (show VWF Antibodies) in a constitution specific manner which could modulate thrombosis/bleeding susceptibility and outcomes of hypoxia, is reported.

  6. Data show that dimethyl-2-ketoglutarate (DKG) inhibits hypoxia-inducible factor 1alpha (HIF-1alpha (show HIF1A Antibodies)) proline hydroxylation and degradation mediated by prolyl-4-hydroxylase PHD2.

  7. The kinetic properties of PHD2 and FIH (show CASR Antibodies) with respect to oxygen reflect their cellular hypoxia-sensing ability.

  8. Germ-line PHD1 (show EGLN2 Antibodies) and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia

  9. The association between EGLN1 and HIF-1AN single nucleotide polymorphisms and acute mountain sickness in a Han Chinese population, was examined.

  10. Compared to those with high PHD2 expressions, patients with low PHD2 expression had significantly longer DFS (show FST Antibodies) and OS periods.

Egl Nine Homolog 1 (C. Elegans) (EGLN1) Antigen Profile

Protein Summary

The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

Gene names and symbols associated with EGLN1

  • egl nine homolog 1 (C. elegans) (EGLN1) antibody
  • egl nine homolog 1 (egln1) antibody
  • egl nine homolog 1 (C. elegans) (egln1) antibody
  • EGL nine homolog 1 (C. elegans) (Egln1) antibody
  • egl-9 family hypoxia-inducible factor 1 (EGLN1) antibody
  • AI503754 antibody
  • C1orf12 antibody
  • ECYT3 antibody
  • EGLN1 antibody
  • egln2 antibody
  • Hif-p4h-2 antibody
  • HIF-PH2 antibody
  • HIFPH2 antibody
  • HPH-2 antibody
  • HPH2 antibody
  • ORF13 antibody
  • PHD-2 antibody
  • PHD2 antibody
  • SM-20 antibody
  • SM20 antibody
  • zgc:92314 antibody
  • ZMYND6 antibody

Protein level used designations for EGLN1

egl nine homolog 1 (C. elegans) , egl nine homolog 1 , egl nine homolog 1-like , egl nine homolog 2 , Hif-p4h-2 , HIF-prolyl hydroxylase 2 , hypoxia-inducible factor prolyl hydroxylase 2 , prolyl hydroxylase domain-containing protein 2 , HIF prolyl hydroxylase 2 , egl nine-like protein 1 , zinc finger MYND domain-containing protein 6

GENE ID SPECIES
421528 Gallus gallus
469708 Pan troglodytes
534075 Bos taurus
100153461 Sus scrofa
100454843 Pongo abelii
100594374 Nomascus leucogenys
446395 Xenopus laevis
436868 Danio rerio
488971 Canis lupus familiaris
112405 Mus musculus
308913 Rattus norvegicus
54583 Homo sapiens
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