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anti-Egl Nine Homolog 1 (C. Elegans) (EGLN1) Antibodies

The protein encoded by EGLN1 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Additionally we are shipping Egl Nine Homolog 1 (C. Elegans) Kits (6) and Egl Nine Homolog 1 (C. Elegans) Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EGLN1 112405 Q91YE3
EGLN1 308913  
EGLN1 54583 Q9GZT9
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Top anti-Egl Nine Homolog 1 (C. Elegans) Antibodies at antibodies-online.com

Showing 10 out of 156 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-EGLN1 Antibody Titration: 1.25ug/mlELISA Titer: 1:12500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated IHC, IHC (p), SimWes, WB Western Blot: EGLN1/PHD2 Antibody (366G/76/3) [NBP1-30328] - Western blot analysis in HeLa whole cell extracts using NBP1-30328. 0.1 mL Log in to see 5 to 7 Days
$381.94
Details
Human Rabbit Un-conjugated FACS, ICC, IF, IHC, IHC (p), IP, SimWes, WB Western Blot analysis of human PHD2, using ABIN151071. Samples: Recombinant DYKDDDDK-His-PHD1, PHD2 or PHD3 (10ng/lane) and whole cell lysate from HeLa cells. 0.1 mg Log in to see 5 to 7 Days
$447.56
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IP, IHC, WB Immunohistochemistry: HIF Prolyl Hydroxylase 2 Antibody [ABIN250635] - Staining of renal tubular epithelium in mouse using ABIN250635 at 2.5ug/ml.  Mouse kidney cortex, 40X. Detection of PHD2 in mouse kidney lysate using ABIN250635. ECL exposure, 20 seconds. 0.1 mL Log in to see 5 to 7 Days
$473.81
Details
Human Rabbit Un-conjugated EM, FACS, ICC, IF, IHC, IHC (p), IP, WB Western blot analysis of human PHD2, using ABIN151072. Samples: Recombinant DYKDDDDK-His-PHD1, PHD2 and PHD3 (10 ng/lane), HeLa whole cell lysate and MEFs. Flow Cytometry: EGLN1/PHD2 Antibody [ABIN151072] - Flow cytometric detection of PHD2, 10^6 Jurkat cells were fixed, permeabilized, and stained with 3.0 ug/ml anti-PHD2 in a 150 ul reaction. 0.1 mL Log in to see 5 to 7 Days
$408.19
Details
Human Mouse Un-conjugated EIA, IF, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (35.35 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Biotin ICC, IF, IHC, IHC (p), WB   0.1 mL Log in to see 5 to 7 Days
$525.00
Details
Human Rabbit Un-conjugated WB EGLN1 Antibody (C-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the EGLN1 antibody detected the EGLN1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details

EGLN1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Egl Nine Homolog 1 (C. Elegans) Antibodies

  1. Human Polyclonal EGLN1 Primary Antibody for FACS, ICC - ABIN151071 : Elvidge, Glenny, Appelhoff, Ratcliffe, Ragoussis, Gleadle: Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. in The Journal of biological chemistry 2006 (PubMed)
    Show all 62 references for ABIN151071

  2. Human Polyclonal EGLN1 Primary Antibody for ICC, IF - ABIN250635 : Mikhaylova, Ignacak, Barankiewicz, Harbaugh, Yi, Maxwell, Schneider, Van Geyte, Carmeliet, Revelo, Wyder, Greis, Meller, Czyzyk-Krzeska: The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. in Molecular and cellular biology 2008 (PubMed)
    Show all 22 references for ABIN250635

  3. Human Polyclonal EGLN1 Primary Antibody for EM, FACS - ABIN151072 : Baek, Mahon, Oh, Kelly, Krishnamachary, Pearson, Chan, Giaccia, Semenza: OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. in Molecular cell 2005 (PubMed)
    Show all 16 references for ABIN151072

  4. Human Polyclonal EGLN1 Primary Antibody for ELISA, WB - ABIN565755 : Aprelikova, Pandolfi, Tackett, Ferreira, Salnikow, Ward, Risinger, Barrett, Niederhuber: Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. in Cancer research 2009 (PubMed)

  5. Dog (Canine) Polyclonal EGLN1 Primary Antibody for WB - ABIN2775907 : Appelhoff, Tian, Raval, Turley, Harris, Pugh, Ratcliffe, Gleadle: Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against Egl Nine Homolog 1 (C. Elegans) Interaction Partners

Xenopus laevis Egl Nine Homolog 1 (C. Elegans) (EGLN1) interaction partners

  1. oxygen via Phd2 has a decisive influence on the formation of the vascular network during vertebrate embryogenesis.

  2. comparative analysis of phd1 (show EGLN2 Antibodies), 2, and 3 expression in Xenopus laevis

Mouse (Murine) Egl Nine Homolog 1 (C. Elegans) (EGLN1) interaction partners

  1. deleting Phd1 (show EGLN2 Antibodies)-3 genes in osteoblasts increased osteoclast formation in vitro and in bone.

  2. Key messages: HIF-P4H-2 deficiency protects skeletal muscle from ischemia-reperfusion injury. The mechanisms involved are mediated via normoxic HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha (show EPAS1 Antibodies) stabilization. HIF-P4H-2 deficiency increases capillary size but not number. HIF-P4H-2 deficiency maintains energy metabolism during ischemia-reperfusion.

  3. Diminished degradation of FLNA upon PHD2 inactivation in hypoxia rearranges the actin cytoskeleton to reduce the number of dendritic spines, synapses.

  4. Stabilized HIF-1alpha (show HIF1A Antibodies) induced by PHD2 conditional knockout resulted in the transition of muscle fibers toward a slow fiber type via a calcineurin (show PPP3CA Antibodies)/NFATc1 (show NFATC1 Antibodies) signaling pathway.

  5. HIF-P4H-2 inhibition may be a novel strategy for protecting against the development of atherosclerosis.

  6. findings show hypoxia and loss of PHD2 revert cancer-associated fibroblast (CAF (show LAMA2 Antibodies)) activation; this reversion is associated with loss of matrix stiffening and consequently reduction in spontaneous metastases to lungs and liver

  7. Data (including data from studies in transgenic/knockout mice) suggest that expression of Phd2/Egln1 in chondrocytes plays key role in chondrogenesis, osteogenesis, and developmental gene expression regulation.

  8. a genetic link between EGLN1 and VWF (show VWF Antibodies) in a constitution specific manner which could modulate thrombosis/bleeding susceptibility and outcomes of hypoxia, is reported.

  9. PHD2 in the liver has a role in survival in lactic acidosis by activating the Cori cycle

  10. Regulatory link was discovered between mitochondrial Txnrd and the JNK (show MAPK8 Antibodies)-PHD2-Hif-1alpha (show HIF1A Antibodies) axis, which highlights how the loss of Txnrd2 (show TXNRD2 Antibodies) and the resulting altered mitochondrial redox balance impairs tumor growth as well as tumor-related angiogenesis.

Human Egl Nine Homolog 1 (C. Elegans) (EGLN1) interaction partners

  1. The role of PHD-2 in breast cancer [review]

  2. Sulfur mustard negatively affects hypoxia-stimulated HIF-1alpha (show HIF1A Antibodies) signaling in keratinocytes and fibroblasts and thus possibly contributes to delayed wound healing in SM-injured patients, which could be treated with PHD-2 inhibitors.

  3. The HIFalpha subunit is usually prolyl-hydroxylated by EglN family members under normoxic conditions, causing its rapid degradation. Study confirmed that triple-negative breast cancer cells secrete glutamate (show GRIN1 Antibodies), which is both necessary and sufficient for the paracrine induction of HIF1alpha (show HIF1A Antibodies) in such cells under normoxic conditions.

  4. Disulfide bond-mediated PHD2 dimerization and inactivation result in the activation of HIF-1alpha (show HIF1A Antibodies) and aerobic glycolysis in response to oxidative stress.

  5. The present study demonstrated that the antiapoptotic effect of TMP in CoCl2-induced HUVECs was, at least in part, via the regulation of the PHD2/HIF-1alpha (show HIF1A Antibodies) signaling pathway.

  6. the levels of both miR (show MLXIP Antibodies)-182 and HIF1alpha (show HIF1A Antibodies) were elevated, while the expression PHD2 and FIH1 (show HIF1AN Antibodies) was downregulated in a mouse model of prostate cancer.

  7. findings show hypoxia and loss of PHD2 revert cancer-associated fibroblast (CAF (show KAT2B Antibodies)) activation

  8. In this article, UTMD/PEI mediated gene transfection was investigated and the US parameters were optimized. Furthermore, the biological effects of PHD2 shRNA were investigated in H9C2 cells.

  9. a genetic link between EGLN1 and VWF (show VWF Antibodies) in a constitution specific manner which could modulate thrombosis/bleeding susceptibility and outcomes of hypoxia, is reported.

  10. Data show that dimethyl-2-ketoglutarate (DKG) inhibits hypoxia-inducible factor 1alpha (HIF-1alpha (show HIF1A Antibodies)) proline hydroxylation and degradation mediated by prolyl-4-hydroxylase PHD2.

Egl Nine Homolog 1 (C. Elegans) (EGLN1) Antigen Profile

Protein Summary

The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

Gene names and symbols associated with EGLN1

  • egl nine homolog 1 (C. elegans) (EGLN1) antibody
  • egl nine homolog 1 (egln1) antibody
  • egl nine homolog 1 (C. elegans) (egln1) antibody
  • EGL nine homolog 1 (C. elegans) (Egln1) antibody
  • egl-9 family hypoxia-inducible factor 1 (EGLN1) antibody
  • AI503754 antibody
  • C1orf12 antibody
  • ECYT3 antibody
  • EGLN1 antibody
  • egln2 antibody
  • Hif-p4h-2 antibody
  • HIF-PH2 antibody
  • HIFPH2 antibody
  • HPH-2 antibody
  • HPH2 antibody
  • ORF13 antibody
  • PHD-2 antibody
  • PHD2 antibody
  • SM-20 antibody
  • SM20 antibody
  • zgc:92314 antibody
  • ZMYND6 antibody

Protein level used designations for EGLN1

egl nine homolog 1 (C. elegans) , egl nine homolog 1 , egl nine homolog 1-like , egl nine homolog 2 , Hif-p4h-2 , HIF-prolyl hydroxylase 2 , hypoxia-inducible factor prolyl hydroxylase 2 , prolyl hydroxylase domain-containing protein 2 , HIF prolyl hydroxylase 2 , egl nine-like protein 1 , zinc finger MYND domain-containing protein 6

GENE ID SPECIES
421528 Gallus gallus
469708 Pan troglodytes
534075 Bos taurus
100153461 Sus scrofa
100454843 Pongo abelii
100594374 Nomascus leucogenys
446395 Xenopus laevis
436868 Danio rerio
488971 Canis lupus familiaris
112405 Mus musculus
308913 Rattus norvegicus
54583 Homo sapiens
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