EGLN1 antibody (AA 301-426)

Catalog No. ABIN7151443

Product Details anti-EGLN1 Antibody

Target: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Binding Specificity: AA 301-426

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EGLN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human, Rat

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Egl nine homolog 1 protein (301-426AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EGLN1

Target: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Alternative Name: EGLN1 (EGLN1 Products)

Synonyms: EGLN1 antibody, egln2 antibody, phd2 antibody, zgc:92314 antibody, AI503754 antibody, C1orf12 antibody, HIF-PH2 antibody, HPH-2 antibody, Hif-p4h-2 antibody, ORF13 antibody, Phd2 antibody, SM-20 antibody, PHD-2 antibody, PHD2 antibody, ECYT3 antibody, HIFPH2 antibody, HPH2 antibody, SM20 antibody, ZMYND6 antibody, egl nine homolog 1 (C. elegans) antibody, egl-9 family hypoxia inducible factor 1 antibody, egl-9 family hypoxia-inducible factor 1 S homeolog antibody, egl-9 family hypoxia-inducible factor 1b antibody, egl-9 family hypoxia-inducible factor 1 antibody, EGLN1 antibody, egln1.S antibody, egln1b antibody, Egln1 antibody

Background:

Background: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferencially recognized via a LXXLAP motif.

Aliases: C1ORF12 antibody, Chromosome 1 Open Reading Frame 12 antibody, DKFZp761F179 antibody, ECYT 3 antibody, ECYT3 antibody, Egl 9 family hypoxia inducible factor 1 antibody, EGL 9 homolog of C. elegans 1 antibody, EGL nine (C.elegans) homolog 1 antibody, Egl nine homolog 1 (C. elegans) antibody, Egl nine homolog 1 antibody, Egl nine like protein 1 antibody, EGLN 1 antibody, Egln1 antibody, EGLN1_HUMAN antibody, HIF PH2 antibody, HIF Prolyl Hydroxylase 2 antibody, HIF-PH2 antibody, HIF-prolyl hydroxylase 2 antibody, HIFP4H 2 antibody, HIFPH2 antibody, HPH 2 antibody, HPH-2 antibody, HPH2 antibody, Hypoxia inducible factor prolyl hydroxylase 2 antibody, Hypoxia-inducible factor prolyl hydroxylase 2 antibody, ORF13 antibody, P4H2 antibody, PHD 2 antibody, PhD2 antibody, PNAS 118 antibody, PNAS 137 antibody, Prolyl Hydroxylase Domain Containing Protein 2 antibody, Prolyl hydroxylase domain-containing protein 2 antibody, Rat Homolog of SM20 antibody, SM 20 antibody, SM-20 antibody, SM20 antibody, Zinc finger MYND domain containing protein 6 antibody, ZMYND6 antibody

UniProt: Q9GZT9

Pathways: cAMP Metabolic Process, Warburg Effect