EGLN1 antibody (C-Term)

Catalog No. ABIN1537273

Product Details anti-EGLN1 Antibody

Target: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Binding Specificity: AA 396-425, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EGLN1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EGLN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-425 amino acids from the C-terminal region of human EGLN1.

Clone: RB39542

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: EGLN1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for EGLN1

Target: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Alternative Name: EGLN1 (EGLN1 Products)

Synonyms: EGLN1 antibody, egln2 antibody, phd2 antibody, zgc:92314 antibody, AI503754 antibody, C1orf12 antibody, HIF-PH2 antibody, HPH-2 antibody, Hif-p4h-2 antibody, ORF13 antibody, Phd2 antibody, SM-20 antibody, PHD-2 antibody, PHD2 antibody, ECYT3 antibody, HIFPH2 antibody, HPH2 antibody, SM20 antibody, ZMYND6 antibody, egl nine homolog 1 (C. elegans) antibody, egl-9 family hypoxia inducible factor 1 antibody, egl-9 family hypoxia-inducible factor 1 S homeolog antibody, egl-9 family hypoxia-inducible factor 1b antibody, egl-9 family hypoxia-inducible factor 1 antibody, EGLN1 antibody, egln1.S antibody, egln1b antibody, Egln1 antibody

Background: The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

Molecular Weight: 46021

Gene ID: 54583

NCBI Accession: NP_071334

UniProt: Q9GZT9

Pathways: cAMP Metabolic Process, Warburg Effect