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The protein encoded by ELAC2 has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. Additionally we are shipping ElaC Homolog 2 (E. Coli) Antibodies (44) and many more products for this protein.
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ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy.
results indicate that ELAC2 functions as a tRNase Z in human mitochondria and suggest that mt-tRNase Z preferentially cleaves molecules already processed by the proteinaceous mtRNase P
ELAC2 and PTCD1 affect the 3' end processing of tRNAs.
analysis of dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation
Data describe polymorphisms in the HPC/ELAC-2 and alpha 1-antitrypsin (show SERPINA1 Proteins) genes that correlate with human diseases in an Indian population.
ELAC2 polymorphisms are associated with prostate cancer.
Our findings corroborate the involvement of ELAC2, MSR1 (show MSR1 Proteins), and RNASEL (show RNASEL Proteins) in the etiology of prostate cancer even in individuals without a family history.
variation in the putative prostate cancer susceptibility gene ELAC2 contributes to the elevated risk of prostate cancer in Afro-Caribbean males from Tobago
Meta-analysis of associations of the Ser217Leu and Ala541Thr variants in ELAC2 (HPC2) and prostate cancer
Although the Leu217 and Thr541 variants of ELAC2 are less common in Japanese than in Caucasians, both variants confer significantly increased risk of prostate cancer in Japanese.
The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
RNase Z 2
, elaC homolog protein 2
, ribonuclease Z 2
, tRNA 3 endonuclease 2
, tRNase Z 2
, tRNase Z(L)
, zinc phosphodiesterase ELAC protein 2
, elaC homolog 2
, heredity prostate cancer protein 2
, putative prostate cancer susceptibility protein HPC2/ELAC2
, tRNase Z (long form)