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EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Endomucin Antibodies (57) and Endomucin Kits (3) and many more products for this protein.
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Human EMCN Protein expressed in Escherichia coli (E. coli) - ABIN1098339
Kinoshita, Nakamura, Ihara, Haraguchi, Hiraoka, Tashiro, Noda: Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity. in FEBS letters 2001
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These results indicate that endomucin prevents leukocyte contact with adhesion molecules in non-inflamed tissues and that downregulation of endomucin is critical to facilitate adhesion of leukocytes into inflamed tissues.
Knockdown of endomucin markedly attenuated endothelial cell growth, migration and tube formation.
A significant association between EMCN and rheumatoid arthritis susceptibility was detected in our Japanese study population. The EMCN allele conferring rheumatoid arthritis susceptibility may also contribute to the pathogenesis of rheumatoid arthritis.
EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001
, gastric cancer antigen Ga34
, mucin 14, endothelial