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anti-Endothelial PAS Domain Protein 1 (EPAS1) Antibodies

EPAS1 encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. Additionally we are shipping EPAS1 Kits (15) and EPAS1 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EPAS1 2034 Q99814
EPAS1 13819 P97481
EPAS1 29452 Q9JHS1
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Top anti-EPAS1 Antibodies at antibodies-online.com

Showing 10 out of 217 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-EPAS1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate Lanes: Human placenta Primary Antibody Dilution: 1:200Secondary Antibody: Anti-rabbit-HRP Secondary Antibody Dilution: 1:0000  Gene Name: Brown: EPAS1 Purple: Haemotoxylin Submitted by: EPAS1 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB EPAS1 Antibody (C-term) (ABIN658111) western blot analysis in human placenta tissue lysates (35 µg/lane). This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, WB EPAS1 Antibody (N-term) (ABIN654664) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated AA, ELISA, ICC, IF, IHC, WB Hif2alpha Western Blotting CoCl treated Hela 20ug 1 in 1000. 100 μg Log in to see 3 to 4 Days
$349.80
Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometric analysis of A549 cells using HIF2A / HIF2 alpha Antibody (N-term) Cat.-No AP51440PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of HIF2A / HIF2 alpha Antibody (N-term) in A549 cell line lysates (35ug/lane). This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Hamster Mouse Un-conjugated ChIP, ELISA, FACS, GS, ICC, IF, IHC, IHC (p), IP, SimWes, WB HIF-2 alpha detected in hypoxic human lysate using ABIN151063. Lane 1: normoxic A549 lysate control, lane 2: hypoxic A549 lysate. Staining of heart, cardiac myocytes using ABIN151063. 0.1 mL Log in to see 7 to 9 Days
$473.81
Details
Fish Rabbit Un-conjugated ChIP, ELISA, FACS, GS, ICC, IF, IHC, IHC (fro), IHC (p), IP, SimWes, WB Western Blot analysis on normoxic and hypoxic nuclear rat cell lysates using ABIN151051, anti-HIF-2 alpha. Hif-2 alpha immunoreactivity in human cardiac myocytes stained with ABIN151051. 0.1 mL Log in to see 7 to 9 Days
$473.81
Details
Hamster Mouse Biotin ELISA, ICC, IF, IHC, IHC (p), WB Staining of heart, cardiac myocytes using ABIN151063. 0.1 mL Log in to see 7 to 9 Days
$538.13
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human kidney cancer labeled with Anti-HIF-2? Polyclonal Antibody, Unconjugated (ABIN686662) followed by conjugation to the secondary antibody and DAB staining Rat lung lysates probed with Rabbit Anti-HIF2 alpha Polyclonal Antibody, Unconjugated  at 1:3000 for 90 min at 37˚C. 100 μL Log in to see 3 to 7 Days
$307.45
Details
Hamster Mouse HRP ELISA, IHC, IHC (p), WB Staining of heart, cardiac myocytes using ABIN151063. 0.1 mL Log in to see 7 to 9 Days
$538.13
Details

EPAS1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-EPAS1 Antibodies

  1. Fish Polyclonal EPAS1 Primary Antibody for ChIP, ELISA - ABIN151051 : Conrad, Freeman, Beitner-Johnson, Millhorn: EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. in The Journal of biological chemistry 1999 (PubMed)
    Show all 459 references for ABIN151051

  2. Hamster Monoclonal EPAS1 Primary Antibody for ChIP, ELISA - ABIN151063 : Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. in The American journal of pathology 2007 (PubMed)
    Show all 137 references for ABIN151063

  3. Hamster Monoclonal EPAS1 Primary Antibody for ELISA, IHC - ABIN250056 : Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. in Biology of reproduction 2004 (PubMed)
    Show all 19 references for ABIN250056

  4. Hamster Monoclonal EPAS1 Primary Antibody for ELISA, ICC - ABIN250055 : Mekhail, Gunaratnam, Bonicalzi, Lee: HIF activation by pH-dependent nucleolar sequestration of VHL. in Nature cell biology 2004 (PubMed)
    Show all 15 references for ABIN250055

  5. Human Monoclonal EPAS1 Primary Antibody for AA, ELISA - ABIN863099 : Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. in The Journal of clinical investigation 2009 (PubMed)
    Show all 4 references for ABIN863099

  6. Human Polyclonal EPAS1 Primary Antibody for EIA, FACS - ABIN952733 : Yi, Liang, Huerta-Sanchez, Jin, Cuo, Pool, Xu, Jiang, Vinckenbosch, Korneliussen, Zheng, Liu, He, Li, Luo, Nie, Wu, Zhao, Cao, Zou, Shan, Li, Yang, Asan, Ni, Tian, Xu, Liu, Jiang, Wu, Zhou, Tang, Qin, Wang, Feng, Li, Huasang, Luosang, Wang, Chen, Wang, Zh: Sequencing of 50 human exomes reveals adaptation to high altitude. in Science (New York, N.Y.) 2010 (PubMed)
    Show all 2 references for ABIN952733

  7. Human Polyclonal EPAS1 Primary Antibody for WB - ABIN658111 : Bougatef, Menashi, Khayati, Naïmi, Porcher, Podgorniak, Millot, Janin, Calvo, Lebbé, Mourah: EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. in PLoS ONE 2010 (PubMed)
    Show all 2 references for ABIN658111

  8. Human Polyclonal EPAS1 Primary Antibody for FACS, WB - ABIN654664 : Mowat, Luhmann, Smith, Lange, Duran, Harten, Shukla, Maxwell, Ali, Bainbridge: HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. in PLoS ONE 2010 (PubMed)
    Show all 2 references for ABIN654664

  9. Chicken Polyclonal EPAS1 Primary Antibody for WB - ABIN2779523 : Koizume, Yokota, Miyagi, Hirahara, Tsuchiya, Miyagi: Heterogeneity in binding and gene-expression regulation by HIF-2alpha. in Biochemical and biophysical research communications 2008 (PubMed)

  10. Human Polyclonal EPAS1 Primary Antibody for IF (p), IHC (p) - ABIN686662 : Li, Chen, Shao, Tang, Chen, Chen, Xu: Oxidative stress induces the decline of brain EPO expression in aging rats. in Experimental gerontology 2016 (PubMed)

More Antibodies against EPAS1 Interaction Partners

Human Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. These results suggested that HIF-2alpha may cause meniscal matrix degradation by transactivation of MMP-13 (show MMP13 Antibodies)

  2. We assessed HIF1A (show HIF1A Antibodies) and EPAS1 expression in a 4-day in vitro culture of primary term cytotrophoblasts under 21% O2 and 2.5% O2. In undifferentiated cytotrophoblasts, EPAS1 transcripts were four times more abundant than HIF1A (show HIF1A Antibodies) transcripts. EPAS1 mRNA and protein expression increased during cytotrophoblast differentiation.

  3. HIF-2alpha and HIF2PUT upregulation may be a common feature in human osteosarcomas with aggressive potency. The over-expression of the two molecules, alone or combined, may predict poor prognosis in osteosarcoma patients.

  4. High HIF2A expression is associated with gastric cancer.

  5. Overexpression of EPAS1 is associated with neoplasms.

  6. The expression of both HIF-2alpha and VEGF mRNA did not relate closely to age.

  7. results show that overexpression of HIFs, regardless of whether the HIF-1alpha (show HIF1A Antibodies) or HIF-2alpha isoforms are overexpressed is significantly associated with increased risk of mortality in oral squamous cell carcinoma patients

  8. Data indicate that decreased endothelial PAS domain-containing protein 1 (EPAS1) mRNA and increased EPAS1 promoter methylation were detected in chronic obstructive pulmonary disease (COPD (show ARCN1 Antibodies)), which were closely associated with increased Toll-Like Receptor 4 (TLR4 (show TLR4 Antibodies)) expression.

  9. MicroRNA-383 is a tumor suppressor in human lung cancer by inhibiting EPAS1, both of which could serve as potential therapeutic targets in the treatment of lung cancer.

  10. these data demonstrated that HIF-2alpha could promote hepatocellular carcinoma cell migration by regulating CDCP1 (show CDCP1 Antibodies)

Mouse (Murine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. The regulatory connection between HIF-2alpha and VEGFR-1 (show FLT1 Antibodies), VEGFR-2 (show KDR Antibodies) and MMP2 (show MMP2 Antibodies).

  2. HIF2alpha is essential for the acute postprandial regulation of hepatic glucagon (show GCG Antibodies) signaling.

  3. demonstrate that HIF-2alpha is clearly implicated in the TSP1 (show GZMA Antibodies) pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction

  4. Findings identify a reciprocal activation mechanism involving HIF-2alpha and the zinc-ZIP8 (show SLC39A8 Antibodies)-MTF1 (show MTF1 Antibodies) axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.

  5. This review emphasizes that sympathetic nervous system homeostasis is dependent on a balance between HIF-2alpha and HIF-1alpha (show HIF1A Antibodies).

  6. genetic analysis suggests that tubulointerstitial cellular crosstalk modulates renal EPO (show EPO Antibodies) production under conditions of epithelial HIF activation in the kidney.

  7. Chondrocytes co-cultured with HIF-2alpha-overexpressing fibroblast-like synoviocytes exhibited upregulation of Mmp3 (show MMP3 Antibodies) and Mmp13 (show MMP13 Antibodies), which is similar to the effects induced by interleukin (IL)-6 (show IL6 Antibodies) treatment of chondrocytes.

  8. HIF-2alpha inhibits high-grade soft tissue sarcoma cell growth. Loss of HIF-2alpha promotes sarcoma proliferation and increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.

  9. HIF-2alpha-deficient mice displayed brown adipose tissue dysregulation, associated with reduced levels of uncoupling protein 1 (UCP1 (show UCP1 Antibodies)) and a dysfunctional thermogenic response to cold exposure.

  10. Loss of Hif-2alpha Rescues the Hif-1alpha (show HIF1A Antibodies) Deletion Phenotype of Neonatal Respiratory Distress In Mice

Pig (Porcine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. immunostaining for HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification

Cow (Bovine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.

EPAS1 Antigen Profile

Protein Summary

This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.

Gene names and symbols associated with EPAS1

  • endothelial PAS domain protein 1 (EPAS1) antibody
  • endothelial PAS domain protein 1 (epas1) antibody
  • endothelial PAS domain protein 1 (Epas1) antibody
  • bhlhe73 antibody
  • ecyt4 antibody
  • EPAS antibody
  • EPAS-1 antibody
  • EPAS1 antibody
  • HIF-2alpha antibody
  • hif2 antibody
  • hif2a antibody
  • hif2alpha antibody
  • hlf antibody
  • HRF antibody
  • mop2 antibody
  • pasd2 antibody

Protein level used designations for EPAS1

endothelial PAS domain protein 1 , endothelial PAS domain-containing protein 1-like , EPAS-1 , HIF-1-alpha-like factor , HIF-1alpha-like factor , HIF-2-alpha , HIF2-alpha , PAS domain-containing protein 2 , basic-helix-loop-helix-PAS protein MOP2 , class E basic helix-loop-helix protein 73 , endothelial PAS domain-containing protein 1 , hypoxia-inducible factor 2 alpha , hypoxia-inducible factor 2-alpha , member of PAS protein 2 , HIF-related factor , HIF1 alpha-like factor , HIF1alpha-like factor , HLF (HIF1alpha-like factor) , Hif like protein , hypoxia inducible transcription factor 2alpha , mHLF , HIF-2 alpha , HIF2 alpha , hypoxia inducible factor 2, alpha subunit , hypoxia inducible factor 2a , HIF-2alpha

GENE ID SPECIES
459204 Pan troglodytes
714641 Macaca mulatta
100220014 Taeniopygia guttata
100396711 Callithrix jacchus
100439667 Pongo abelii
100543912 Meleagris gallopavo
100551891 Anolis carolinensis
100606638 Nomascus leucogenys
2034 Homo sapiens
13819 Mus musculus
29452 Rattus norvegicus
444145 Xenopus laevis
395596 Gallus gallus
474578 Canis lupus familiaris
100037272 Sus scrofa
282711 Bos taurus
100068622 Equus caballus
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