anti-Endothelial PAS Domain Protein 1 (EPAS1) Antibodies

EPAS1 encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. antibodies-online currently ships , and to destinations worldwide.

list all antibodies Gene Name GeneID UniProt
EPAS1 2034 Q99814
EPAS1 13819 P97481
EPAS1 29452 Q9JHS1

Show Endothelial PAS Domain Protein 1 (EPAS1) Antigen Profile

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Top anti-Endothelial PAS Domain Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 178 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Mouse Un-conjugated WB, ChIP, FACS, ICC, IF, IHC, IHC (p), IP Staining of heart, cardiac myocytes using ABIN151063. 25 μL 9 to 11 Days
229,90 $
Details
Human Mouse Un-conjugated WB, ChIP, FACS, ICC, IF, IHC, IHC (p), IP HIF-2 alpha detected in hypoxic human lysate using ABIN151063. Lane 1: normoxic A549 lysate control, lane 2: hypoxic A549 lysate. Staining of heart, cardiac myocytes using ABIN151063. 0.1 mL 9 to 11 Days
399,30 $
Details
Human Rabbit Un-conjugated FACS, WB EPAS1 Antibody (N-term) (ABIN654664) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow). 400 μL 2 to 4 Days
291,50 $
Details
Human Rabbit Un-conjugated WB EPAS1 Antibody (C-term) (ABIN658111) western blot analysis in human placenta tissue lysates (35 µg/lane). This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow). 400 μL 2 to 4 Days
291,50 $
Details
Human Mouse Biotin WB, IHC, IHC (p) Staining of heart, cardiac myocytes using ABIN151063. 0.1 mL 9 to 11 Days
435,60 $
Details
Human Mouse HRP WB, IHC, IHC (p) Staining of heart, cardiac myocytes using ABIN151063. 0.1 mL 9 to 11 Days
447,70 $
Details
Mouse Rabbit Un-conjugated WB <b>WB Suggested Anti-EPAS1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>293T cell lysate Lanes: Human placenta <br />Primary Antibody Dilution: 1:200<br />Secondary Antibody: Anti-rabbit-HRP <br />Secondary Antibody Dilution: 1:0000 <br /> Gene Name: Brown: EPAS1 Purple: Haemotoxylin <br /><br />Submitted by: EPAS1 50 μg 2 to 3 Days
289,00 $
Details
Human Mouse Un-conjugated ICC, IF, IHC, WB Hif2alpha Western Blotting CoCl treated Hela 20ug 1 in 1000. 25 μg 3 to 4 Days
179,30 $
Details
Fish Rabbit Biotin WB, IHC, IHC (p) Western Blot analysis on normoxic and hypoxic nuclear rat cell lysates using ABIN151051, anti-HIF-2 alpha. Hif-2 alpha immunoreactivity in human cardiac myocytes stained with ABIN151051. 0.1 mL 9 to 11 Days
435,60 $
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB   0.1 mL 9 to 11 Days
496,10 $
Details

EPAS1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) , , , ,
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Top referenced anti-Endothelial PAS Domain Protein 1 Antibodies

  1. ABIN249868 : Alvarez-Tejado, Naranjo-Suarez, Jimuenez, Carrera, Landuazuri, del Peso: Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. in The Journal of biological chemistry 2001 (PubMed)
    Show all 17 references for ABIN249868

  2. ABIN250056 : Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. in The American journal of pathology 2007 (PubMed)
    Show all 15 references for ABIN250056

  3. ABIN250055 : Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. in Biology of reproduction 2004 (PubMed)
    Show all 15 references for ABIN250055

More Antibodies against Endothelial PAS Domain Protein 1 Interaction Partners

Human Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. This study demonstrates a novel function of HIF (HIF1a (show HIF1A Antibodies) and HIF2a)in regulating RNA splicing of HIF target genes

  2. EPAS-1 specifically regulates SP-1-mediated FBI-1 expression and tumor cell proliferation.

  3. HIF-1 (show HIF1A Antibodies) and HIF-2 directly activate the expression of AXL (show AXL Antibodies) and GAS6 (show GAS6 Antibodies)/AXL (show AXL Antibodies) signaling uses lateral activation of the met proto-oncogene (MET) through SRC (show SRC Antibodies) proto-oncogene (show RAB1A Antibodies) nonreceptor tyrosine kinase (show TXK Antibodies) to maximize cellular invasion.

  4. TRPM2 (show CLU Antibodies)-L function may be a novel approach to reduce tumor growth through modulation of HIF-1 (show HIF1A Antibodies)/2a, mitochondrial function, and mitophagy.

  5. activation of HIF2alpha/VE-PTP (show PTPRB Antibodies) signaling via PHD2 (show EGLN1 Antibodies) inhibition has the potential to prevent the formation of leaky vessels and edema in inflammatory diseases such as ARDS

  6. Upregulated EPAS1 expression in hypoxic colorectal cancer cells that were associated with DNA demethylation of the EPAS1 regulatory region.

  7. High HIF-2alpha expression is associated with angiogenesis in hepatocellular carcinoma.

  8. Somatic HIF2alpha mutations clearly document the existence of an additional phenotype of this syndrome, that is, ocular abnormalities in addition to paraganglioma, somatostatinoma, and polycythemia.

  9. consecutive increase in HIF2alpha activity promotes the expression of various transporters and enzymes supporting the reductive and oxidative glutamine (show GFPT1 Antibodies) metabolism, whereas a reduction in functional HIF1alpha (show HIF1A Antibodies) expression consolidates the inhibition of glycolysis

  10. of 5% O2 rejuvenates WJ-MSC (show MSC Antibodies) culture toward less-differentiated, more primitive and faster-growing phenotypes with involvement of HIF-1a (show HIF1A Antibodies) and HIF-2a-mediated and TSA (show PRDX2 Antibodies)-sensitive chromatin modification mechanisms.

Mouse (Murine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. These results suggest that there is a compensatory pathway involving HIF-1alpha (show HIF1A Antibodies) that regulates the expression of some HIF-2alpha target genes.

  2. 713 HIF-1 (show HIF1A Antibodies) and 795 HIF-2 binding sites were identified under hypoxia. Pretreatment with IL-10 (show IL10 Antibodies) altered the binding pattern, with 120 new HIF-1 (show HIF1A Antibodies) and 188 new HIF-2 binding sites emerging

  3. Chronic activation of HIF-2 in renal juxtaglomerular cells leads to a reprogramming of the cells into fibroblast-like cells resembling native erythropoietin (show EPO Antibodies)-producing cells located in the tubulointerstitium.

  4. activation of HIF2alpha/VE-PTP (show PTPRB Antibodies) signaling via PHD2 (show EGLN1 Antibodies) inhibition has the potential to prevent the formation of leaky vessels and edema in inflammatory diseases such as ARDS

  5. Hypoxic treatment of primary keratinocytes induced filaggrin (Flg (show FLG Antibodies)) gene expression in a HIF1alpha (show HIF1A Antibodies)- and HIF2alpha-dependent manner.

  6. HIF-2alpha/IGF-1R (show IGF1R Antibodies) signal loop supports the proliferation and Oct4 (show POU5F1 Antibodies) maintenance of mouse germline stem cells.

  7. HIF2, but not HIF1 (show SETD2 Antibodies), is both necessary and sufficient to prevent radiation-induced GI toxicity and death in knockout mice

  8. these data suggest that macrophage HIF-2alpha would counteract the proinflammatory responses to relieve obesity-induced insulin (show INS Antibodies) resistance in adipose tissue.

  9. Study shows that oxygen tension, mediated by Oligodendrocyte precursor cells (OPC)-encoded HIF function, is an essential regulator of postnatal myelination; constitutive HIF1 (show SETD2 Antibodies)/2alpha stabilization resulted in OPC maturation arrest through autocrine activation of canonical Wnt7a (show WNT7A Antibodies)/7b.

  10. HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha promote angiogenesis of residual hepatocellular carcinoma after high-intensity focused ultrasound ablation.

Pig (Porcine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. immunostaining for HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification

Endothelial PAS Domain Protein 1 (EPAS1) Antigen Profile

Gene names and symbols associated with EPAS1

endothelial PAS domain protein 1 (EPAS1) , endothelial PAS domain protein 1 (epas1) , endothelial PAS domain protein 1 (Epas1)

EPAS1 , ECYT4 , HIF2A , HLF , MOP2 , PASD2 , bHLHe73 , HIF-2alpha , HRF , Hif2a , bhlhe73 , ecyt4 , hif2 , hif2a , hif2alpha , hlf , mop2 , pasd2 , EPAS , EPAS-1

Protein level used designations for EPAS1

endothelial PAS domain protein 1 , endothelial PAS domain-containing protein 1-like , EPAS-1 , HIF-1-alpha-like factor , HIF-1alpha-like factor , HIF-2-alpha , HIF2-alpha , PAS domain-containing protein 2 , basic-helix-loop-helix-PAS protein MOP2 , class E basic helix-loop-helix protein 73 , endothelial PAS domain-containing protein 1 , hypoxia-inducible factor 2 alpha , hypoxia-inducible factor 2-alpha , member of PAS protein 2 , HIF-related factor , HIF1 alpha-like factor , HIF1alpha-like factor , HLF (HIF1alpha-like factor) , Hif like protein , hypoxia inducible transcription factor 2alpha , mHLF , HIF-2 alpha , HIF2 alpha , hypoxia inducible factor 2, alpha subunit , hypoxia inducible factor 2a , HIF-2alpha

Antigen Summary

This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.

GENE ID SPECIES
459204 Pan troglodytes
714641 Macaca mulatta
100220014 Taeniopygia guttata
100396711 Callithrix jacchus
100439667 Pongo abelii
100543912 Meleagris gallopavo
100551891 Anolis carolinensis
100606638 Nomascus leucogenys
2034 Homo sapiens
13819 Mus musculus
29452 Rattus norvegicus
444145 Xenopus laevis
395596 Gallus gallus
474578 Canis lupus familiaris
100037272 Sus scrofa
282711 Bos taurus
100068622 Equus caballus
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