Endothelial PAS Domain Protein 1 (EPAS1) Antibodies

EPAS1 encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. antibodies-online currently ships , and Endothelial PAS Domain Protein 1 (EPAS1) Kits (9) to destinations worldwide.

list all antibodies Gene Name GeneID UniProt
EPAS1 2034 Q99814
Anti-Mouse EPAS1 EPAS1 13819 P97481
Anti-Rat EPAS1 EPAS1 29452 Q9JHS1

Show Endothelial PAS Domain Protein 1 (EPAS1) Antigen Profile

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Top Endothelial PAS Domain Protein 1 (EPAS1) Antibodies at antibodies-online.com

Showing 10 out of 138 Endothelial PAS Domain Protein 1 (EPAS1) Antibodies

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Mouse Un-conjugated WB, ChIP, FACS, ICC, IF, IHC, IHC (p), IP Staining of heart, cardiac myocytes using ABIN151063. 0.025 mL 9 to 11 Days
246.84 $
Details
Human Mouse Un-conjugated WB, ChIP, FACS, ICC, IF, IHC, IHC (p), IP HIF-2 alpha detected in hypoxic human lysate using ABIN151063. Lane 1: normoxic A549 lysate control, lane 2: hypoxic A549 lysate. Staining of heart, cardiac myocytes using ABIN151063. 0.1 mL 9 to 11 Days
450.12 $
Details
Human Rabbit Un-conjugated WB, FACS EPAS1 Antibody (N-term) (ABIN654664) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow). 400 µL 2 to 3 Days
291.50 $
Details
Human Rabbit Un-conjugated WB EPAS1 Antibody (C-term) (ABIN658111) western blot analysis in human placenta tissue lysates (35 µg/lane). This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow). 400 µL 2 to 3 Days
291.50 $
Details
Human Mouse Biotin WB, IHC, IHC (p) Staining of heart, cardiac myocytes using ABIN151063. 0.1 mL 9 to 11 Days
595.32 $
Details
Human Mouse HRP WB, IHC, IHC (p) Staining of heart, cardiac myocytes using ABIN151063. 0.1 mL 9 to 11 Days
595.32 $
Details
Mouse Rabbit Un-conjugated WB <b>WB Suggested Anti-EPAS1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>293T cell lysate Lanes: Human placenta <br />Primary Antibody Dilution: 1:200<br />Secondary Antibody: Anti-rabbit-HRP <br />Secondary Antibody Dilution: 1:0000 <br /> Gene Name: Brown: EPAS1 Purple: Haemotoxylin <br /><br />Submitted by: EPAS1 50 µg 2 to 3 Days
289.00 $
Details
Human Mouse Un-conjugated WB, IHC, ICC, IF Hif2alpha Western Blotting CoCl treated Hela 20ug 1 in 1000. 25 μg 3 to 4 Days
179.30 $
Details
Fish Rabbit Biotin WB, IHC, IHC (p) Western Blot analysis on normoxic and hypoxic nuclear rat cell lysates using ABIN151051, anti-HIF-2 alpha. Hif-2 alpha immunoreactivity in human cardiac myocytes stained with ABIN151051. 0.1 mL 9 to 11 Days
595.32 $
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB   0.1 mL 9 to 11 Days
566.28 $
Details

EPAS1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced Endothelial PAS Domain Protein 1 (EPAS1) Antibodies

  1. ABIN249868 : Alvarez-Tejado, Naranjo-Suarez, Jimuenez, Carrera, Landuazuri, del Peso: Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. in The Journal of biological chemistry 2001 (PubMed)
    Show all 17 references for ABIN249868

  2. ABIN250056 : Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. in The American journal of pathology 2007 (PubMed)
    Show all 15 references for ABIN250056

  3. ABIN250055 : Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. in Biology of reproduction 2004 (PubMed)
    Show all 15 references for ABIN250055

More Antibodies against Endothelial PAS Domain Protein 1 (EPAS1) Interaction Partners

Human Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. PRMT1 (show PRMT1 Antibodies) is a novel regulator of HIF-1 (show HIF1A Antibodies)- and HIF-2-mediated responses.

  2. Data show that forkhead transcription factor 4 (FoxO4) interacts with sterol regulatory element binding protein (SREBP)2 and hypoxia inducible factor (HIF)2alpha to modulate lanosterol 14alpha demethylase (CYP51) promoter activity.

  3. Exposure of human breast cancer cells to hypoxia augments microvesicle (MVs) shedding that is mediated by the HIF-dependent expression of the small GTPase (show RACGAP1 Antibodies) RAB22A (show RAB22A Antibodies), which colocalizes with budding MVs at the cell surface.

  4. Data suggest that hypoxia-induced expression of BOK (Bcl-2-related ovarian killer protein (show BOK Antibodies)) in placental cells is regulated via promoter region, hypoxia-response element, and binding of hypoxia-inducible factors (HIF1A (show HIF1A Antibodies), HIF2A/EPAS1, HIF1B/ARNT (show ARNT Antibodies)).

  5. The acetate-dependent acetyl CoA (show LPCAT2 Antibodies) generator ACSS2 (show ACSS2 Antibodies) links changes in metabolism that occur during stress with the coupled processes of HIF-2 acetylation, which is mediated by the acetylase/coactivator CBP (show CREBBP Antibodies), and stable HIF-2/CBP (show CREBBP Antibodies) complex formation, both of which are required for maximal HIF-2 signaling.

  6. HIF-1alpha (show HIF1A Antibodies) overexpression was significantly associated with poor overall survival of colorectal cancer patients, particularly in Asian countries, while overexpression of HIF-2alpha was only associated with grade of tumor differentiation. (Meta-analysis)

  7. Overexpression of HIF2A is associated with metastatic clear-cell renal cell carcinoma (show MOK Antibodies).

  8. HIF-1 (show HIF1A Antibodies) and HIF-2 specific gene activating functions respond differently to different stimuli.

  9. all classes of RNA are profoundly regulated by hypoxia and implicated HIF as a major direct regulator of both the non-coding and coding transcriptome, acting predominantly through release of pre-bound promoter-paused RNApol2.

  10. Hif-1alpha (show HIF1A Antibodies) and Hif-2alpha competitively bind to NICD (show NOTCH1 Antibodies).

Mouse (Murine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. Study shows that oxygen tension, mediated by Oligodendrocyte precursor cells (OPC)-encoded HIF function, is an essential regulator of postnatal myelination; constitutive HIF1 (show SETD2 Antibodies)/2alpha stabilization resulted in OPC maturation arrest through autocrine activation of canonical Wnt7a (show WNT7A Antibodies)/7b.

  2. HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha promote angiogenesis of residual hepatocellular carcinoma after high-intensity focused ultrasound ablation.

  3. results suggest that the HIF-2alpha/ARNT (show ARNT Antibodies) complex regulates hair follicle differentiation via induction of p21(Waf1/Cip1 (show CDKN1A Antibodies)) and possibly p27(Kip1 (show CDKN1B Antibodies))

  4. LPS (show TLR4 Antibodies) preconditioning protected against renal ischemia/reperfusion injury by HIF-2alpha activation in endothelial cells that subsequently improved renal microvascular perfusion and reduced ischemic tubular damage.

  5. The acetate-dependent acetyl CoA (show LPCAT1 Antibodies) generator Acss2 (show ACSS2 Antibodies) links changes in metabolism that occur during stress with the coupled processes of Hif-2 acetylation, which is mediated by the acetylase/coactivator Cbp (show CREBBP Antibodies), and stable Hif-2/Cbp (show CREBBP Antibodies) complex formation, both of which are required for maximal Hif-2 signaling.

  6. Suggest that in anemia each organ expresses a different threshold for cellular HIF/NOS hypoxia responses.

  7. inactivation of endothelial HIF-2alpha, but not endothelial HIF-1alpha (show HIF1A Antibodies), resulted in increased expression of renal injury markers and inflammatory cell infiltration in the postischemic kidney, which was reversed by blockade of VCAM1 (show VCAM1 Antibodies) and VLA4

  8. HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha regulate eosinophil migration and asthma airway resistance in opposing ways.

  9. In proximal tubular cells, AGE-BSA stimulation elevated mainly HIF-1alpha (show HIF1A Antibodies) transcriptional activity and to a lesser extent HIF-2alpha.

  10. both HIF2alpha and ETS1 (show ETS1 Antibodies) are involved in the transcriptional regulation of Flvcr1a and that HIF2alpha is absolutely required for Flvcr1a induction upon hypoxia

Endothelial PAS Domain Protein 1 (EPAS1) Antigen Profile

Gene names and symbols associated with EPAS1

endothelial PAS domain protein 1 (EPAS1) , endothelial PAS domain protein 1 (epas1) , endothelial PAS domain protein 1 (Epas1)

EPAS1 , ECYT4 , HIF2A , HLF , MOP2 , PASD2 , bHLHe73 , HIF-2alpha , HRF , Hif2a , bhlhe73 , ecyt4 , hif2 , hif2a , hif2alpha , hlf , mop2 , pasd2 , EPAS , EPAS-1

Protein level used designations for EPAS1

endothelial PAS domain protein 1 , endothelial PAS domain-containing protein 1-like , EPAS-1 , HIF-1-alpha-like factor , HIF-1alpha-like factor , HIF-2-alpha , HIF2-alpha , PAS domain-containing protein 2 , basic-helix-loop-helix-PAS protein MOP2 , class E basic helix-loop-helix protein 73 , endothelial PAS domain-containing protein 1 , hypoxia-inducible factor 2 alpha , hypoxia-inducible factor 2-alpha , member of PAS protein 2 , HIF-related factor , HIF1 alpha-like factor , HIF1alpha-like factor , HLF (HIF1alpha-like factor) , Hif like protein , hypoxia inducible transcription factor 2alpha , mHLF , HIF-2 alpha , HIF2 alpha , hypoxia inducible factor 2, alpha subunit , hypoxia inducible factor 2a , HIF-2alpha

Antigen Summary

This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.

GENE ID SPECIES
459204 Pan troglodytes
714641 Macaca mulatta
100220014 Taeniopygia guttata
100396711 Callithrix jacchus
100439667 Pongo abelii
100543912 Meleagris gallopavo
100551891 Anolis carolinensis
100606638 Nomascus leucogenys
2034 Homo sapiens
13819 Mus musculus
29452 Rattus norvegicus
444145 Xenopus laevis
395596 Gallus gallus
474578 Canis lupus familiaris
100037272 Sus scrofa
282711 Bos taurus
100068622 Equus caballus
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