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anti-Endothelial PAS Domain Protein 1 (EPAS1) Antibodies

EPAS1 encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. Additionally we are shipping Endothelial PAS Domain Protein 1 Kits (13) and Endothelial PAS Domain Protein 1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EPAS1 2034 Q99814
EPAS1 13819 P97481
EPAS1 29452 Q9JHS1
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Top anti-Endothelial PAS Domain Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 176 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB <b>WB Suggested Anti-EPAS1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>293T cell lysate Lanes: Human placenta <br />Primary Antibody Dilution: 1:200<br />Secondary Antibody: Anti-rabbit-HRP <br />Secondary Antibody Dilution: 1:0000 <br /> Gene Name: Brown: EPAS1 Purple: Haemotoxylin <br /><br />Submitted by: EPAS1 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB EPAS1 Antibody (C-term) (ABIN658111) western blot analysis in human placenta tissue lysates (35 µg/lane). This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, WB EPAS1 Antibody (N-term) (ABIN654664) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometric analysis of A549 cells using HIF2A / HIF2 alpha Antibody (N-term) Cat.-No AP51440PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of HIF2A / HIF2 alpha Antibody (N-term) in A549 cell line lysates (35ug/lane). This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated ICC, IF, IHC, ELISA, WB   100 μg Log in to see 3 to 4 Days
$349.80
Details
Human Mouse Un-conjugated IHC (fro), IHC (p), ELISA, WB   0.1 mL Log in to see 5 to 6 Days
$486.22
Details
Human Rabbit Un-conjugated ChIP, WB WB Image HIF2 alpha antibody detects HIF2 alpha protein by western blot analysis. A. 30 μg HepG2 whole cell lysate/extract B. 30 μg HepG2 whole cell lysate/extract (1% O2 treatment for 24 hr) 7.5 % SDS-PAGE HIF2 alpha antibody , dilution: 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated ICC, IHC (p), ELISA, WB 25 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 14 Days
$259.64
Details
Rat Rabbit Un-conjugated IHC (p), WB Anti-HIF-2-alpha antibody,  Western blotting WB: Rat Brain Tissue Lysate Anti-HIF-2-alpha antibody,  IHC(P) IHC(P): Rat Small Intestine Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details

EPAS1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Rat (Rattus) , , , ,
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Top referenced anti-Endothelial PAS Domain Protein 1 Antibodies

  1. Human EPAS1 Primary Antibody for IHC (fro), IHC (p) - ABIN1742588 : Wiesener, Turley, Allen, Willam, Eckardt, Talks, Wood, Gatter, Harris, Pugh, Ratcliffe, Maxwell: Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. in Blood 1998 (PubMed)
    Show all 4 references for ABIN1742588

  2. Human Monoclonal EPAS1 Primary Antibody for ICC, IF - ABIN863099 : Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. in The Journal of clinical investigation 2009 (PubMed)
    Show all 4 references for ABIN863099

  3. Human Polyclonal EPAS1 Primary Antibody for FACS, WB - ABIN654664 : Bougatef, Menashi, Khayati, Naïmi, Porcher, Podgorniak, Millot, Janin, Calvo, Lebbé, Mourah: EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. in PLoS ONE 2010 (PubMed)
    Show all 2 references for ABIN654664

  4. Human Polyclonal EPAS1 Primary Antibody for EIA, FACS - ABIN952733 : Yi, Liang, Huerta-Sanchez, Jin, Cuo, Pool, Xu, Jiang, Vinckenbosch, Korneliussen, Zheng, Liu, He, Li, Luo, Nie, Wu, Zhao, Cao, Zou, Shan, Li, Yang, Asan, Ni, Tian, Xu, Liu, Jiang, Wu, Zhou, Tang, Qin, Wang, Feng, Li, Huasang, Luosang, Wang, Chen, Wang, Zh: Sequencing of 50 human exomes reveals adaptation to high altitude. in Science (New York, N.Y.) 2010 (PubMed)
    Show all 2 references for ABIN952733

  5. Human Polyclonal EPAS1 Primary Antibody for WB - ABIN658111 : Mowat, Luhmann, Smith, Lange, Duran, Harten, Shukla, Maxwell, Ali, Bainbridge: HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. in PLoS ONE 2010 (PubMed)
    Show all 2 references for ABIN658111

  6. Human Monoclonal EPAS1 Primary Antibody for FACS, IHC (p) - ABIN137697 : Catrina, Botusan, Rantanen, Catrina, Pyakurel, Savu, Axelson, Biberfeld, Poellinger, Brismar: Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006 (PubMed)

  7. Chicken Polyclonal EPAS1 Primary Antibody for WB - ABIN2779523 : Koizume, Yokota, Miyagi, Hirahara, Tsuchiya, Miyagi: Heterogeneity in binding and gene-expression regulation by HIF-2alpha. in Biochemical and biophysical research communications 2008 (PubMed)

More Antibodies against Endothelial PAS Domain Protein 1 Interaction Partners

Human Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. Demonstrate that mTORC1 inhibition leads to AKT (show AKT1 Antibodies) activation and an increase in HIF2A expression, leading to chondrogenic differentiation of amniotic fluid stem cells.

  2. Most human soft tissue sarcomas have lower levels of EPAS1 expression relative to normal tissue.

  3. these data reveal a novel mechanism for the regulation of the expression of HIF2a, demonstrating that the HIF2a promoter is regulated by E2F1 (show E2F1 Antibodies) directly and that Cezanne (show OTUD7B Antibodies) regulates HIF2a expression through control of E2F1 (show E2F1 Antibodies) levels

  4. HIF2alpha-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma (show MOK Antibodies)

  5. although Hif-1alpha (show HIF1A Antibodies) and Hif-2alpha synergize to suppress the development of acute myeloid leukemia (show BCL11A Antibodies), they are not required for leukemic stem cells maintenance.

  6. the genetic polymorphism of the EPAS1 gene may lead to variation of its gene expression levels to drive progression of the cancer and serve as a prognostic marker for NSCLC.

  7. The associations between HIF2A variants and different level of high altitude support that extremely high-altitude hypoxia challenge imposes selective effects on HIF2A variants among native Tibetans.

  8. Conditional inactivation of Vegfa (show VEGFA Antibodies), Hif1a (show HIF1A Antibodies), or Epas1 in recruited and resident myeloid cells that accumulated at sites of neovascularization did not significantly reduce choroidal neovascularization or oxygen-induced retinopathy.

  9. Data show that knockdown of hypoxia-inducible factor-2alpha (HIF-2alpha) expression reduced HeLa cell colony formation and invasion capacity under both normoxic and hypoxic conditions.

  10. HIF3alpha has a transcriptional regulatory function, which negatively affects gene expression by competing with HIF1alpha (show HIF1A Antibodies) and HIF2alpha in binding to transcriptional elements in target genes during hypoxia. (Review)

Mouse (Murine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. HIF-2alpha inhibits high-grade soft tissue sarcoma cell growth. Loss of HIF-2alpha promotes sarcoma proliferation and increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.

  2. HIF-2alpha-deficient mice displayed brown adipose tissue dysregulation, associated with reduced levels of uncoupling protein 1 (UCP1 (show UCP1 Antibodies)) and a dysfunctional thermogenic response to cold exposure.

  3. Loss of Hif-2alpha Rescues the Hif-1alpha (show HIF1A Antibodies) Deletion Phenotype of Neonatal Respiratory Distress In Mice

  4. although Hif-1alpha (show HIF1A Antibodies) and Hif-2alpha synergize to suppress the development of acute myeloid leukemia (show BCL11A Antibodies), they are not required for leukemic stem cells maintenance.

  5. Letter: HIF2alpha is expressed in a distinct spatial and temporal pattern throughout venous thrombus resolution.

  6. Results show that HIF2-a is up regulated in an in vitro model of nicotine plus lipopolysccharide-stimulated periodontal ligament cell line and primary culture. Its inhibition exhibits anti-inflammatory activity.

  7. High expression of HIF-2A is associated with leukemia and lymphoma.

  8. HIF2alpha has a cardiomyogenesis-promoting effect in embryonic stem cells via enhancing the activation of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.

  9. data suggest that targeting intestinal HIF-2alpha has a significant therapeutic potential in SCD (show SCD Antibodies) pathophysiology

  10. these results suggest that PTEN (show PTEN Antibodies) is required for apoptosis-mediated cavitation during epithelial morphogenesis by regulating the expression of HIF-2alpha and Bnip3 (show BNIP3 Antibodies)

Pig (Porcine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. immunostaining for HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification

Cow (Bovine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.

Endothelial PAS Domain Protein 1 (EPAS1) Antigen Profile

Protein Summary

This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.

Gene names and symbols associated with EPAS1

  • endothelial PAS domain protein 1 (EPAS1) antibody
  • endothelial PAS domain protein 1 (epas1) antibody
  • endothelial PAS domain protein 1 (Epas1) antibody
  • bhlhe73 antibody
  • ecyt4 antibody
  • EPAS antibody
  • EPAS-1 antibody
  • EPAS1 antibody
  • HIF-2alpha antibody
  • hif2 antibody
  • hif2a antibody
  • hif2alpha antibody
  • hlf antibody
  • HRF antibody
  • mop2 antibody
  • pasd2 antibody

Protein level used designations for EPAS1

endothelial PAS domain protein 1 , endothelial PAS domain-containing protein 1-like , EPAS-1 , HIF-1-alpha-like factor , HIF-1alpha-like factor , HIF-2-alpha , HIF2-alpha , PAS domain-containing protein 2 , basic-helix-loop-helix-PAS protein MOP2 , class E basic helix-loop-helix protein 73 , endothelial PAS domain-containing protein 1 , hypoxia-inducible factor 2 alpha , hypoxia-inducible factor 2-alpha , member of PAS protein 2 , HIF-related factor , HIF1 alpha-like factor , HIF1alpha-like factor , HLF (HIF1alpha-like factor) , Hif like protein , hypoxia inducible transcription factor 2alpha , mHLF , HIF-2 alpha , HIF2 alpha , hypoxia inducible factor 2, alpha subunit , hypoxia inducible factor 2a , HIF-2alpha

GENE ID SPECIES
459204 Pan troglodytes
714641 Macaca mulatta
100220014 Taeniopygia guttata
100396711 Callithrix jacchus
100439667 Pongo abelii
100543912 Meleagris gallopavo
100551891 Anolis carolinensis
100606638 Nomascus leucogenys
2034 Homo sapiens
13819 Mus musculus
29452 Rattus norvegicus
444145 Xenopus laevis
395596 Gallus gallus
474578 Canis lupus familiaris
100037272 Sus scrofa
282711 Bos taurus
100068622 Equus caballus
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