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EPAS1 encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. Additionally we are shipping EPAS1 Kits (15) and EPAS1 Proteins (10) and many more products for this protein.
Showing 10 out of 217 products:
Fish Polyclonal EPAS1 Primary Antibody for ChIP, ELISA - ABIN151051
Conrad, Freeman, Beitner-Johnson, Millhorn: EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. in The Journal of biological chemistry 1999
Show all 459 references for ABIN151051
Hamster Monoclonal EPAS1 Primary Antibody for ChIP, ELISA - ABIN151063
Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. in The American journal of pathology 2007
Show all 137 references for ABIN151063
Hamster Monoclonal EPAS1 Primary Antibody for ELISA, IHC - ABIN250056
Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. in Biology of reproduction 2004
Show all 19 references for ABIN250056
Hamster Monoclonal EPAS1 Primary Antibody for ELISA, ICC - ABIN250055
Mekhail, Gunaratnam, Bonicalzi, Lee: HIF activation by pH-dependent nucleolar sequestration of VHL. in Nature cell biology 2004
Show all 15 references for ABIN250055
Human Monoclonal EPAS1 Primary Antibody for AA, ELISA - ABIN863099
Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. in The Journal of clinical investigation 2009
Show all 4 references for ABIN863099
Human Polyclonal EPAS1 Primary Antibody for EIA, FACS - ABIN952733
Yi, Liang, Huerta-Sanchez, Jin, Cuo, Pool, Xu, Jiang, Vinckenbosch, Korneliussen, Zheng, Liu, He, Li, Luo, Nie, Wu, Zhao, Cao, Zou, Shan, Li, Yang, Asan, Ni, Tian, Xu, Liu, Jiang, Wu, Zhou, Tang, Qin, Wang, Feng, Li, Huasang, Luosang, Wang, Chen, Wang, Zh: Sequencing of 50 human exomes reveals adaptation to high altitude. in Science (New York, N.Y.) 2010
Show all 2 references for ABIN952733
Human Polyclonal EPAS1 Primary Antibody for WB - ABIN658111
Bougatef, Menashi, Khayati, Naïmi, Porcher, Podgorniak, Millot, Janin, Calvo, Lebbé, Mourah: EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. in PLoS ONE 2010
Show all 2 references for ABIN658111
Human Polyclonal EPAS1 Primary Antibody for FACS, WB - ABIN654664
Mowat, Luhmann, Smith, Lange, Duran, Harten, Shukla, Maxwell, Ali, Bainbridge: HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. in PLoS ONE 2010
Show all 2 references for ABIN654664
Chicken Polyclonal EPAS1 Primary Antibody for WB - ABIN2779523
Koizume, Yokota, Miyagi, Hirahara, Tsuchiya, Miyagi: Heterogeneity in binding and gene-expression regulation by HIF-2alpha. in Biochemical and biophysical research communications 2008
Human Polyclonal EPAS1 Primary Antibody for IF (p), IHC (p) - ABIN686662
Li, Chen, Shao, Tang, Chen, Chen, Xu: Oxidative stress induces the decline of brain EPO expression in aging rats. in Experimental gerontology 2016
These results suggested that HIF-2alpha may cause meniscal matrix degradation by transactivation of MMP-13 (show MMP13 Antibodies)
We assessed HIF1A (show HIF1A Antibodies) and EPAS1 expression in a 4-day in vitro culture of primary term cytotrophoblasts under 21% O2 and 2.5% O2. In undifferentiated cytotrophoblasts, EPAS1 transcripts were four times more abundant than HIF1A (show HIF1A Antibodies) transcripts. EPAS1 mRNA and protein expression increased during cytotrophoblast differentiation.
HIF-2alpha and HIF2PUT upregulation may be a common feature in human osteosarcomas with aggressive potency. The over-expression of the two molecules, alone or combined, may predict poor prognosis in osteosarcoma patients.
High HIF2A expression is associated with gastric cancer.
Overexpression of EPAS1 is associated with neoplasms.
The expression of both HIF-2alpha and VEGF mRNA did not relate closely to age.
results show that overexpression of HIFs, regardless of whether the HIF-1alpha (show HIF1A Antibodies) or HIF-2alpha isoforms are overexpressed is significantly associated with increased risk of mortality in oral squamous cell carcinoma patients
Data indicate that decreased endothelial PAS domain-containing protein 1 (EPAS1) mRNA and increased EPAS1 promoter methylation were detected in chronic obstructive pulmonary disease (COPD (show ARCN1 Antibodies)), which were closely associated with increased Toll-Like Receptor 4 (TLR4 (show TLR4 Antibodies)) expression.
MicroRNA-383 is a tumor suppressor in human lung cancer by inhibiting EPAS1, both of which could serve as potential therapeutic targets in the treatment of lung cancer.
these data demonstrated that HIF-2alpha could promote hepatocellular carcinoma cell migration by regulating CDCP1 (show CDCP1 Antibodies)
The regulatory connection between HIF-2alpha and VEGFR-1 (show FLT1 Antibodies), VEGFR-2 (show KDR Antibodies) and MMP2 (show MMP2 Antibodies).
HIF2alpha is essential for the acute postprandial regulation of hepatic glucagon (show GCG Antibodies) signaling.
demonstrate that HIF-2alpha is clearly implicated in the TSP1 (show GZMA Antibodies) pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction
Findings identify a reciprocal activation mechanism involving HIF-2alpha and the zinc-ZIP8 (show SLC39A8 Antibodies)-MTF1 (show MTF1 Antibodies) axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.
This review emphasizes that sympathetic nervous system homeostasis is dependent on a balance between HIF-2alpha and HIF-1alpha (show HIF1A Antibodies).
genetic analysis suggests that tubulointerstitial cellular crosstalk modulates renal EPO (show EPO Antibodies) production under conditions of epithelial HIF activation in the kidney.
Chondrocytes co-cultured with HIF-2alpha-overexpressing fibroblast-like synoviocytes exhibited upregulation of Mmp3 (show MMP3 Antibodies) and Mmp13 (show MMP13 Antibodies), which is similar to the effects induced by interleukin (IL)-6 (show IL6 Antibodies) treatment of chondrocytes.
HIF-2alpha inhibits high-grade soft tissue sarcoma cell growth. Loss of HIF-2alpha promotes sarcoma proliferation and increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.
HIF-2alpha-deficient mice displayed brown adipose tissue dysregulation, associated with reduced levels of uncoupling protein 1 (UCP1 (show UCP1 Antibodies)) and a dysfunctional thermogenic response to cold exposure.
Loss of Hif-2alpha Rescues the Hif-1alpha (show HIF1A Antibodies) Deletion Phenotype of Neonatal Respiratory Distress In Mice
immunostaining for HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a