anti-Endothelial PAS Domain Protein 1 (EPAS1) Antibodies

EPAS1 encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. antibodies-online currently ships , and to destinations worldwide.

list all antibodies Gene Name GeneID UniProt
EPAS1 2034 Q99814
EPAS1 13819 P97481
EPAS1 29452 Q9JHS1
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Top anti-Endothelial PAS Domain Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 193 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Mouse Un-conjugated WB, ChIP, FACS, ICC, IF, IHC, IHC (p), IP Staining of heart, cardiac myocytes using ABIN151063. 25 μL 9 to 11 Days
242,00 $
Details
Human Rabbit Un-conjugated FACS, WB EPAS1 Antibody (N-term) (ABIN654664) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow). 400 μL 2 to 4 Days
291,50 $
Details
Human Rabbit Un-conjugated WB EPAS1 Antibody (C-term) (ABIN658111) western blot analysis in human placenta tissue lysates (35 µg/lane). This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow). 400 μL 2 to 4 Days
291,50 $
Details
Human Mouse Un-conjugated WB, ChIP, FACS, ICC, IF, IHC, IHC (p), IP HIF-2 alpha detected in hypoxic human lysate using ABIN151063. Lane 1: normoxic A549 lysate control, lane 2: hypoxic A549 lysate. Staining of heart, cardiac myocytes using ABIN151063. 0.1 mL 9 to 11 Days
399,30 $
Details
Human Mouse Un-conjugated ICC, IF, IHC, WB Hif2alpha Western Blotting CoCl treated Hela 20ug 1 in 1000. 25 μg 3 to 4 Days
179,30 $
Details
Chicken Rabbit Un-conjugated WB <b>WB Suggested Anti-EPAS1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>293T cell lysate Lanes: Human placenta <br />Primary Antibody Dilution: 1:200<br />Secondary Antibody: Anti-rabbit-HRP <br />Secondary Antibody Dilution: 1:0000 <br /> Gene Name: Brown: EPAS1 Purple: Haemotoxylin <br /><br />Submitted by: EPAS1 50 μg 2 to 3 Days
289,00 $
Details
Human Mouse Biotin WB, IHC, IHC (p) Staining of heart, cardiac myocytes using ABIN151063. 0.1 mL 9 to 11 Days
459,80 $
Details
Human Mouse HRP WB, IHC, IHC (p) Staining of heart, cardiac myocytes using ABIN151063. 0.1 mL 9 to 11 Days
471,90 $
Details
Fish Rabbit Un-conjugated WB, ChIP, FACS, GS, ICC, IF, IHC, IHC (fro), IHC (p), IP Western Blot: HIF-2 alpha Antibody [ABIN151051SS] - Western Blot analysis on normoxic and hypoxic nuclear rat cell lysates using ABIN151051, anti-HIF-2 alpha. Immunohistochemistry: HIF-2 alpha Antibody [ABIN151051SS] - Hif-2 alpha immunoreactivity in human cardiac myocytes stained with ABIN151051. 25 μL 9 to 11 Days
242,00 $
Details
Fish Rabbit Biotin WB, IHC, IHC (p) Western Blot analysis on normoxic and hypoxic nuclear rat cell lysates using ABIN151051, anti-HIF-2 alpha. Hif-2 alpha immunoreactivity in human cardiac myocytes stained with ABIN151051. 0.1 mL 9 to 11 Days
459,80 $
Details

EPAS1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Endothelial PAS Domain Protein 1 Antibodies

  1. ABIN249868 : Alvarez-Tejado, Naranjo-Suarez, Jimuenez, Carrera, Landuazuri, del Peso: Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. in The Journal of biological chemistry 2001 (PubMed)
    Show all 17 references for ABIN249868

  2. ABIN151063 : Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. in The American journal of pathology 2007 (PubMed)
    Show all 15 references for ABIN151063

  3. ABIN250056 : Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. in Biology of reproduction 2004 (PubMed)
    Show all 15 references for ABIN250056

  4. ABIN250055 : Mekhail, Gunaratnam, Bonicalzi, Lee: HIF activation by pH-dependent nucleolar sequestration of VHL. in Nature cell biology 2004 (PubMed)
    Show all 15 references for ABIN250055

  5. ABIN863098 : Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. in The Journal of clinical investigation 2009 (PubMed)
    Show all 4 references for ABIN863098

  6. ABIN654664 : Bougatef, Menashi, Khayati, Naïmi, Porcher, Podgorniak, Millot, Janin, Calvo, Lebbé, Mourah: EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. in PLoS ONE 2010 (PubMed)
    Show all 2 references for ABIN654664

  7. ABIN658111 : Mowat, Luhmann, Smith, Lange, Duran, Harten, Shukla, Maxwell, Ali, Bainbridge: HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. in PLoS ONE 2010 (PubMed)
    Show all 2 references for ABIN658111

  8. ABIN151064 : Grabmaier, A de Weijert, Verhaegh, Schalken, Oosterwijk: Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. in Oncogene 2004 (PubMed)
    Show all 2 references for ABIN151064

  9. ABIN486914 : Koizume, Yokota, Miyagi, Hirahara, Tsuchiya, Miyagi: Heterogeneity in binding and gene-expression regulation by HIF-2alpha. in Biochemical and biophysical research communications 2008 (PubMed)

More Antibodies against Endothelial PAS Domain Protein 1 Interaction Partners

Human Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. This study indicates that autophagy has an anticancer role in clear-cell renal cell carcinoma (show MOK Antibodies) tumorigenesis, and suggests that constitutive autophagic degradation of HIF2alpha is a novel tumor suppression mechanism.

  2. EPAS1 knockdown by siRNA in endothelial cells impacted genes that significantly overlapped with EPAS1 downstream genes in lung tissue including hypoxia responsive genes, and genes associated with emphysema severity.

  3. findings suggest that TACC3 (show TACC3 Antibodies) could be recruited as a bridge to cooperatively mediate between the HIF-2alpha PAS (show PASK Antibodies)-B.ARNT PAS (show PASK Antibodies)-B complex, thereby participating more directly in HIF-dependent gene transcription than previously anticipated

  4. Simultaneous HIF-1a and HIF-2a gene knockdown attenuates acquired radioresistance in Hela cells.

  5. HIF-2alpha regulates NANOG (show NANOG Antibodies) expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct (show Plxna2 Antibodies)-Sox (show PIPOX Antibodies) cis (show CISH Antibodies) regulatory element.

  6. the undetectable PHD3 (show EGLN3 Antibodies) could contribute to the higher HIF-alpha expression in ccRCC.

  7. the c-Myc (show MYC Antibodies)-mediated transcriptional repression of miR (show MLXIP Antibodies)-15-16 in hypoxia is induced by increased HIF-2alpha and promoted tumor angiogenesis and hematogenous metastasis by the further loss of post-transcriptional inhibition of FGF2 (show FGF2 Antibodies).

  8. miR185 may be a tumor suppressor, affecting the development of colon cancer via inhibition of HIF2a signaling.

  9. This study demonstrates a novel function of HIF (HIF1a (show HIF1A Antibodies) and HIF2a)in regulating RNA splicing of HIF target genes

  10. EPAS-1 specifically regulates SP-1-mediated FBI-1 expression and tumor cell proliferation.

Mouse (Murine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. pivotal role in the pathogenesis of rheumatoid arthritis by regulating fibroblast-like synoviocyte functions, independent of HIF-1alpha (show HIF1A Antibodies)

  2. The PTEN (show PTEN Antibodies)/PI3K/AKT (show AKT1 Antibodies) signaling axis controls hypoxia-induced HIF1alpha (HIF1A (show HIF1A Antibodies)) and HIF2alpha (EPAS1) stability in macrophages.

  3. we showed that muscles did not require macrophagic hif1a (show HIF1A Antibodies) or hif2a to regenerate. These results indicate that macrophagic HIFs do not play a crucial role during skeletal muscle regeneration induced by sterile tissue damage.

  4. These results suggest that there is a compensatory pathway involving HIF-1alpha (show HIF1A Antibodies) that regulates the expression of some HIF-2alpha target genes.

  5. 713 HIF-1 (show HIF1A Antibodies) and 795 HIF-2 binding sites were identified under hypoxia. Pretreatment with IL-10 (show IL10 Antibodies) altered the binding pattern, with 120 new HIF-1 (show HIF1A Antibodies) and 188 new HIF-2 binding sites emerging

  6. Chronic activation of HIF-2 in renal juxtaglomerular cells leads to a reprogramming of the cells into fibroblast-like cells resembling native erythropoietin (show EPO Antibodies)-producing cells located in the tubulointerstitium.

  7. activation of HIF2alpha/VE-PTP (show PTPRB Antibodies) signaling via PHD2 (show EGLN1 Antibodies) inhibition has the potential to prevent the formation of leaky vessels and edema in inflammatory diseases such as ARDS

  8. Hypoxic treatment of primary keratinocytes induced filaggrin (Flg (show FLG Antibodies)) gene expression in a HIF1alpha (show HIF1A Antibodies)- and HIF2alpha-dependent manner.

  9. HIF-2alpha/IGF-1R (show IGF1R Antibodies) signal loop supports the proliferation and Oct4 (show POU5F1 Antibodies) maintenance of mouse germline stem cells.

  10. HIF2, but not HIF1 (show SETD2 Antibodies), is both necessary and sufficient to prevent radiation-induced GI toxicity and death in knockout mice

Pig (Porcine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. immunostaining for HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification

Endothelial PAS Domain Protein 1 (EPAS1) Antigen Profile

Antigen Summary

This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.

Gene names and symbols associated with EPAS1

  • endothelial PAS domain protein 1 (EPAS1) antibody
  • endothelial PAS domain protein 1 (epas1) antibody
  • endothelial PAS domain protein 1 (Epas1) antibody
  • EPAS1 antibody
  • ECYT4 antibody
  • HIF2A antibody
  • HLF antibody
  • MOP2 antibody
  • PASD2 antibody
  • bHLHe73 antibody
  • HIF-2alpha antibody
  • HRF antibody
  • Hif2a antibody
  • bhlhe73 antibody
  • ecyt4 antibody
  • hif2 antibody
  • hif2a antibody
  • hif2alpha antibody
  • hlf antibody
  • mop2 antibody
  • pasd2 antibody
  • EPAS antibody
  • EPAS-1 antibody

Protein level used designations for EPAS1

endothelial PAS domain protein 1 , endothelial PAS domain-containing protein 1-like , EPAS-1 , HIF-1-alpha-like factor , HIF-1alpha-like factor , HIF-2-alpha , HIF2-alpha , PAS domain-containing protein 2 , basic-helix-loop-helix-PAS protein MOP2 , class E basic helix-loop-helix protein 73 , endothelial PAS domain-containing protein 1 , hypoxia-inducible factor 2 alpha , hypoxia-inducible factor 2-alpha , member of PAS protein 2 , HIF-related factor , HIF1 alpha-like factor , HIF1alpha-like factor , HLF (HIF1alpha-like factor) , Hif like protein , hypoxia inducible transcription factor 2alpha , mHLF , HIF-2 alpha , HIF2 alpha , hypoxia inducible factor 2, alpha subunit , hypoxia inducible factor 2a , HIF-2alpha

GENE ID SPECIES
459204 Pan troglodytes
714641 Macaca mulatta
100220014 Taeniopygia guttata
100396711 Callithrix jacchus
100439667 Pongo abelii
100543912 Meleagris gallopavo
100551891 Anolis carolinensis
100606638 Nomascus leucogenys
2034 Homo sapiens
13819 Mus musculus
29452 Rattus norvegicus
444145 Xenopus laevis
395596 Gallus gallus
474578 Canis lupus familiaris
100037272 Sus scrofa
282711 Bos taurus
100068622 Equus caballus
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