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Endothelin 1 Proteins (EDN1)

The protein encoded by EDN1 is proteolytically processed to release a secreted peptide termed endothelin 1. Additionally we are shipping Endothelin 1 Antibodies (230) and Endothelin 1 Kits (105) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EDN1 1906 P05305
EDN1 24323 P22388
EDN1 13614 P22387
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Top Endothelin 1 Proteins at

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag Endothelin 1 (EDN1) (AA 53-73), (full length) protein (GST tag) 50 μg Log in to see 9 to 11 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human GST tag,His tag   50 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Pig His tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Pig Un-conjugated   100 μg Log in to see 9 to 19 Days

EDN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)

Mouse (Murine)

Top referenced Endothelin 1 Proteins

  1. Human Endothelin 1 Protein expressed in Escherichia coli (E. coli) - ABIN1046972 : Itoh, Yanagisawa, Ohkubo, Kimura, Kosaka, Inoue, Ishida, Mitsui, Onda, Fujino: Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. in FEBS letters 1988 (PubMed)
    Show all 3 references for ABIN1046972

  2. Human Endothelin 1 Protein expressed in Wheat germ - ABIN1352324 : Schildroth, Rettig-Zimmermann, Kalk, Steege, Fähling, Sendeski, Paliege, Lai, Bachmann, Persson, Hocher, Patzak: Endothelin type A and B receptors in the control of afferent and efferent arterioles in mice. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011 (PubMed)

More Proteins for Endothelin 1 (EDN1) Interaction Partners

Zebrafish Endothelin 1 (EDN1) interaction partners

  1. Phylogenetic analysis of conserved grhl (show GHRL Proteins)-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 (show GRHL3 Proteins) target gene, and this was confirmed by chromatin precipitation assays in embryos.

  2. EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.

  3. Data suggest that edn1/ednraa (show EDNRA Proteins) (endothelin-1/endothelin-1 receptor type A (show EDNRA Proteins)) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase in zebrafish embryonic skin.

  4. These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.

  5. Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.

  6. activation of Endothelin-1 signaling in craniofacial patterning

  7. Edn1 from the pharyngeal ectoderm signals through Ednra (show EDNRA Proteins) proteins to direct early dorsoventral patterning of the skeletogenic neural crest.

  8. The role of endothelin-1 and light in the regulation of melanopsins and the clock proteins in an embyronic cell line is reported.

Xenopus laevis Endothelin 1 (EDN1) interaction partners

  1. This is the first report describing the cDNA encoding preproendothelin-1 in an amphibian species.

  2. A new role for et-1 signaling during early neural crest specification is reported.

Human Endothelin 1 (EDN1) interaction partners

  1. Congenital heart disease complicated with pulmonary artery hypertension is associated with increased circulating endothelial cell counts and ET-1 production.

  2. demonstration that pericardial fluid (PF) of cardiac patients elicit substantial arterial constrictions, which is mediated primarily by ET-1; interfering with the vasoconstrictor action of PF could be a potential therapeutic target to improve coronary blood flow in cardiac patients

  3. EDN1 as a key factor towards the generation and clonal derivation of ISL1 (show ISL1 Proteins)(+) vascular intermediates.

  4. Data show that plasma levels of endothelial microparticle (EMP (show MAEA Proteins)) and endothelin-1 (ET-1 are significantly higher in intermediate )lesion group, while their nitric oxide (NO) and nitric oxide synthase 3 (eNOS (show NOS3 Proteins)) are lower.

  5. we show that fenofibrate, a PPAR-alpha (show PPARA Proteins) agonist, increased the expression of miR (show MLXIP Proteins)-301a/miR (show MLXIP Proteins)-454 and SKA2 (show FAM33A Proteins) in human microvascular endothelial cell line (HMEC) cells; the former were responsible for reduced expression of ET-1 and PAI-1 (show SERPINE1 Proteins)

  6. Peripheral endothelin-1 and transforming growth factor-beta1 levels, which strongly correlate with their hepatic levels, reflect the stage of portal hypertension and liver insufficiency in cirrhosis.

  7. excessive ET-1 production in the setting of HIV infection impairs pulmonary endothelial function and contributes to the development of pulmonary arterial hypertension .

  8. The data demonstrated that the plasma big endothelin 1 level was a valuable independent predictor for coronary artery calcification.

  9. Circulating endothelin-1 levels may predict coronary heart disease in women.

  10. A(8002)G intronic polymorphism of pre-pro-endothelin-1 gene is associated with elevated endothelin-1 levels among Tunisian coronary patients.

Pig (Porcine) Endothelin 1 (EDN1) interaction partners

  1. sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation

  2. ET1 was lowest in kidneys removed from live pigs, greater in kidneys from pigs with brain death, and greatest in kidneys from pigs with cardiac arrest.

  3. ET-1 contributes to formation of oedema during experimental sepsis by a novel mechanism involving increased HBP (show HEBP1 Proteins) release from neutrophils.

  4. Endothelin-1 expression is upregulated following therapeutic hypothermia after cardiac arrest.

  5. ET-1 produces contraction of the urinary bladder neck muscles via muscular ET(A (show EDNRA Proteins)) receptors coupled to extracellular Ca(2 (show CA2 Proteins)+) entry via VOC (L-type) and non-VOC channels.

  6. Endothelin-1 elevation is not only a conserved phenomenon in a pig traumatic brain injury (TBI (show TBPL1 Proteins)) model, but it is a likely target for understanding the observed enhanced vascular response to TBI (show TBPL1 Proteins).

  7. interleukin-6 (show IL6 Proteins), endothelin ET-1, and apoptotic Bak (show BAK1 Proteins) and Bcl-XL (show BCL2L1 Proteins) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury

  8. ET-1 elicits a different pattern of Src (show SRC Proteins) family kinase (SFK) activation and might trigger a different pattern of SFK activation from that caused by ATP and UTP.

  9. Compared with the untreated group, the levels of serum ET-1 after acute myocardial infarction and reperfusion were significantly decreased in the Xuefu Zhuyu-treated group.

  10. study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1 (show ECE1 Proteins)) acting via endothelin receptor A (show EDNRA Proteins) in the control of luteolytic sensitivity in the pig

Cow (Bovine) Endothelin 1 (EDN1) interaction partners

  1. We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 (show PLA2G4A Proteins) activity in the cell membrane.

  2. Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.

  3. Oxidized LDL is a stimulus of ET-1 production in cultured vascular endothelial cells.

  4. Endothelin-1 decreases ethanolamine plasmalogen levels and evokes platelet-activating factor production in brain microvessels

  5. prostaglandin F2alpha, endothelin-1, and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis

  6. LOX-1 (show OLR1 Proteins) and CD40 (show CD40 Proteins) synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.

  7. Elevated local expression of ET-1 and Ednra/Ednrb (show EDNRB Proteins) during the peri (show PLIN1 Proteins)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.

  8. Suggest that the activation of a local positive feedback mechanism in the corpus luteum among ET-1, Ang II (show AGT Proteins) and PGF2alpha might play a functional role in the paracrine modulation of luteolytic cascade.

  9. The combined metabolic burden of homocysteine and high glucose stimulates ET-1 synthesis in bovine aortic endothelial cells via a mechanism dependent on the production of mitochondrial ROS (show ROS1 Proteins), but may not be generalisable to all types of endothelial cells.

  10. hypoxia and endothelin-1 have roles in mediating vasa (show DDX4 Proteins) vasorum neovascularization with pulmonary artery adventitial fibroblasts

Mouse (Murine) Endothelin 1 (EDN1) interaction partners

  1. indicate that endothelin-1 is critical in the development of cerebrovascular and cognitive impairments with experimental cerebral malaria

  2. increased extrarenal vascular ET-1 production in response to HS intake is mediated by increased extracellular osmolarity and plays a critical role in regulating skin storage of Na(+)

  3. PPARgamma (show PPARG Proteins) regulates miR (show MLXIP Proteins)-98 to modulate ET-1 expression and pulmonary endothelial cell proliferation in pulmonary hypertension.

  4. these results indicated that I/R induced upregulation of ET1 and ETA in the kidneys, which was, at least in part, dependent on the production of inflammatory cytokines.

  5. we have demonstrated that the expression of ET-1 and IL-25 (show IL25 Proteins) was coordinately upregulated in the lesional keratinocytes of patients with AD and a murine AD model.

  6. The cardiac expression of prepro-endothelin-1 mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight. Furthermore, endothelin-1 plasma levels showed an increasing trend.

  7. This study showed a novel SIRT1 (show SIRT1 Proteins) mediated protection against renal and retinal injury in diabetes, regulated through p300 (show NOTCH1 Proteins), ET-1 and TGF-beta1 (show TGFB1 Proteins).

  8. these results mechanistically link the innate immune response mediated by IkappaBbeta (show NFKBIB Proteins)/NF-kappaB (show NFKB1 Proteins) to ET-1 expression and potentially reveal therapeutic targets for patients with Gram-negative septic shock.

  9. ET-1 overexpressing astrocytic cells showed amyloid secretion after hypoxia/ischemia insult suggests a role of astrocytic ET-1 in dementia associated with stroke by astrocyte-derived amyloid production

  10. These results demonstrated that enhanced endothelin system activity could be a causative factor in the development of PAH and provided rationale for the inhibition of endothelin system to treat PAH.

Horse (Equine) Endothelin 1 (EDN1) interaction partners

  1. Short-term hyperinsulinaemia leads to increased vascular resistance in the equine digit and increased expression of ET-1 in the laminar tissue.

Rabbit Endothelin 1 (EDN1) interaction partners

  1. Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury

  2. In a saline lavage-induced lung injury model, both circulatory and pulmonary ET-1 levels increased.

  3. Data suggest elevated levels of endothelin-1, as exhibited in cardiovascular diseases, facilitate development of ventricular arrhythmia by steepening action potential duration restitution and by increasing beat-to-beat variability of repolarization.

  4. High levels of ET-1 are closely associated with BBB disruption. ET-1 may play an important role in the pathogenesis of secondary brain injury after ICH (show ACE Proteins).

  5. After subarachnoid hemorrhage, the contractile response to ET-1 was enhanced, and the ET(A (show EDNRA Proteins)) receptor expression was upregulated in the basilar artery.

  6. After acute pulmonary thromboembolism, thrombolytic and anti-inflammatory treatment could decrease acute lung injury induced by ET-1 and NF-kappaB (show NFKB1 Proteins) activation. [endothelin-1; NFKB]

  7. The increase in myocardial distensibility induced by endothelin-1 is absent in heart failure and is dependent on nitric oxide and prostaglandin release.

  8. Endothelin-1 enhances nuclear Ca2 (show CA2 Proteins)+ transients in atrial myocytes through Ins (show INS Proteins)(1,4,5)P3-dependent Ca2 (show CA2 Proteins)+ release from perinuclear Ca2 (show CA2 Proteins)+ stores

  9. The enhancement of gap junction intercellular communication is activated by endothelin-1 via modulating the expression of connexin43 (show GJA1 Proteins), and plays an important role in the pathogenesis of cerebral vasospasm

Endothelin 1 (EDN1) Protein Profile

Protein Summary

The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Endothelin 1 Proteins (EDN1)

  • endothelin 1 (edn1)
  • endothelin 1 (EDN1)
  • endothelin 1 (edn1-a)
  • endothelin 1 (Edn1)
  • endothelin-1 (ET-1)
  • EDN protein
  • Edn1 protein
  • ET-1 protein
  • Et1 protein
  • fb14d01 protein
  • HDLCQ7 protein
  • PPET-1 protein
  • PPET1 protein
  • preproET protein
  • wu:fb14d01 protein

Protein level used designations for Endothelin 1 Proteins (EDN1)

endothelin-1 , et1 , suc , sucker , endothelin 1 , preproendothelin-1 , ET-1 , PPET1 , gene for endothelin , preproendothelin , Preproendothelin-1 , preproendothelin 1

100144700 Xenopus (Silurana) tropicalis
58032 Danio rerio
462437 Pan troglodytes
100036806 Xenopus laevis
100294653 Ovis aries
1906 Homo sapiens
443498 Ovis aries
24323 Rattus norvegicus
403424 Canis lupus familiaris
396915 Sus scrofa
281137 Bos taurus
13614 Mus musculus
100726197 Cavia porcellus
494214 Felis catus
699982 Macaca mulatta
100034060 Equus caballus
420854 Gallus gallus
100009270 Oryctolagus cuniculus
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