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Endothelin 3 Proteins (EDN3)

The protein encoded by EDN3 is a member of the endothelin family. Additionally we are shipping Endothelin 3 Antibodies (81) and Endothelin 3 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EDN3 1908 P14138
Mouse EDN3 EDN3 13616 P48299
Rat EDN3 EDN3 366270 P13207
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Top Endothelin 3 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   1 mg Log in to see 6 to 11 Days
$334.29
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 9 to 11 Days
$229.85
Details
Human Un-conjugated   1 mg Log in to see 6 Days
$285.21
Details

EDN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Endothelin 3 (EDN3) Interaction Partners

Xenopus laevis Endothelin 3 (EDN3) interaction partners

  1. This is the first report of the cDNA encoding the precursor protein of ET-3 in a non-mammalian species.

Human Endothelin 3 (EDN3) interaction partners

  1. EDN3 expression in left internal mammary arteries depends on tissue harvesting technique.

  2. Down-regulated expression of ET3 attenuates the malignant behaviors of human melanoma cells partially by decreasing the expression of SPARC (show SPARC Proteins).

  3. Waardenburg syndrome type II and mutations of EDNRB (show EDNRB Proteins), EDN3 and SOX10 (show SOX10 Proteins) genes are responsible for Waardenburg syndrome type IV. (review)

  4. Our data showed that almost all patients, regardless of individual characteristics such as gender or age, expressed the endothelin receptor genes, but did not express the genes for ET-3.

  5. Studies revealed hypermethylation of EDN2 (show EDN2 Proteins) and EDN3 genes in human primary colon cancers and in a panel of human colon cancer cell lines. Epigenetic inactivation of ET-2 (show EDN2 Proteins) and ET-3 occurs frequently in both rat and human colon cancers.

  6. plasma levels of big ET-2 (show EDN2 Proteins), and big ET-3 are markedly increased in patients with end stage renal disease on hemodialysis

  7. A novel missense mutation in EDN3 and a deletion mutation in DMD (show DMD Proteins) has been found in the same Indian family members affected with Waardenburg syndrome and Duchenne muscular dystrophy (show DMD Proteins).

  8. These data suggest that autocrine EDN3/EDNRB (show EDNRB Proteins) signaling is essential for maintaining GSCs. Incorporating END3 (show EPHA3 Proteins)/EDNRB (show EDNRB Proteins)-targeted therapies into conventional cancer treatments may have clinical implication for the prevention of tumor recurrence.

  9. ET-1 (show EDN1 Proteins) and the ET-1 (show EDN1 Proteins)/ET-3 ratio are elevated in cirrhotic patients with portopulmonary hypertension (PPHT) and that ET-1 (show EDN1 Proteins) is associated with a poor outcome irrespective of PPHT.

  10. Finding suggest that mutations in RET (show RET Proteins) and NTRK3 (show NTRK3 Proteins) acting together are necessary and sufficient for the appearance of Hirschsprung disease and that the EDN3 mutation acts as a phenotype modifier.

Mouse (Murine) Endothelin 3 (EDN3) interaction partners

  1. colonic migrating motor complexes occur in mice lacking the endothelin-3 gene

  2. Enterocolitis causes profound lymphoid depletion in endothelin receptor B (show EDNRB Proteins)- and endothelin 3-null mouse models of Hirschsprung-associated enterocolitis.

  3. changes in spinal afferent innervation and visceral pain transmission from the aganglionic rectum in ls/ls mice with deletions of the endothelin-3 gene

  4. EDN3 worked synergistically to induce melanocyte differentiation in vitro

  5. a coordinate and balanced interaction between SOX10 (show SOX10 Proteins), endothelin-3 and endothelin B receptor (show EDNRB Proteins) is required for normal enteric nervous system and melanocyte development

  6. Using quantitative real-time polymerase chain reaction (PCR) we demonstrated reduced levels of endothelin-3 mRNA in the male mouse bowel at the time that ENS precursors migrate into the colon.

  7. an ENU-induced mutation in endothelin 3 results in a mouse model of Waardenburg syndrome type IV

  8. Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model.

Pig (Porcine) Endothelin 3 (EDN3) interaction partners

  1. Polymorphisms within the EDN3 gene are associated with meat color in the pig.

Endothelin 3 (EDN3) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

Gene names and symbols associated with Endothelin 3 Proteins (EDN3)

  • endothelin-3 (et-3)
  • endothelin 3 (EDN3)
  • endothelin 3 (Edn3)
  • endothelin 3 (LOC100348609)
  • 114CH19 protein
  • EDN3 protein
  • ET-3 protein
  • Et3 protein
  • HSCR4 protein
  • ls protein
  • PPET3 protein
  • preproET-3 protein
  • RGD1564825 protein
  • tmgc48 protein
  • WS4B protein

Protein level used designations for Endothelin 3 Proteins (EDN3)

endothelin-3 , endothelin 3 , preproendothelin-3 , lethal spotting , ET-3 , PPET3

GENE ID SPECIES
100036807 Xenopus laevis
469989 Pan troglodytes
768509 Gallus gallus
1908 Homo sapiens
13616 Mus musculus
366270 Rattus norvegicus
403406 Canis lupus familiaris
100049663 Sus scrofa
513753 Bos taurus
100348609 Oryctolagus cuniculus
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