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Endothelin-converting enzymes, such as ECE2 (EC 220.127.116.11), are type II metalloproteases that generate functionally pleiotropic members of the endothelin vasoactive peptide family (Lorenzo et al., 2001 [PubMed 11718899]).[supplied by OMIM, Mar 2008].. Additionally we are shipping ECE2 Antibodies (35) and ECE2 Kits (3) and many more products for this protein.
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Human ECE2 Protein expressed in Human Cells - ABIN2002348
Emoto, Yanagisawa: Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. in The Journal of biological chemistry 1995
Show all 3 references for ABIN2002348
Te results of this study suggested taht genetic variations in MMEL1 (show MMEL1 Proteins), ECE1 (show ECE1 Proteins), ECE2, AGER (show AGER Proteins), PLG (show PLG Proteins), PLAT (show PLAT Proteins), NR1H3 (show NR1H3 Proteins), MMP3 (show MMP3 Proteins), LRP1 (show LRP1 Proteins), TTR (show TTR Proteins), NR1H2 (show NR1H2 Proteins), and MMP9 (show MMP9 Proteins) genes do not play major role among the Finnish AD patient cohort.
The PL405 assay is thus the first tool to study ECE-2 inhibition using high throughput screening or for ex vivo ECE-2 quantification.
Data show that CD133 and ECE (show ECE1 Proteins) expressions are associated with lymphoid metastasis and prognosis of NSCLC, and their overexpression often suggests unfavorable prognosis of NSCLC.
The most significantly downregulated gene in this data set was the endothelin converting enzyme 2 (ECE2), implicated in amyloid beta clearance.
An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene
Abeta (show APP Proteins) accumulation in Alzheimer's disease is unlikely to be caused by ECE-2 deficiency. However, ECE-2 expression is up-regulated
These results suggest that ECE2, by selectively processing endogenous opioid peptides in the endocytic compartment, plays a role in modulating opioid receptor activity
a role for differential modulation of opioid receptor signaling by post-endocytic processing of peptide agonists by ECE2.
ECE-2 has a role in the non-classical processing of spinal cord peptides and morphine responses, including the cleavage of a number of neuropeptides at non-classical sites in vitro.
deficits in learning and memory in ECE2 knockout mice may provide unique insights into processes that may contribute to this disease and possible other disorders of cognition
novel four subisoforms of ECE-2 that differ in their N-terminal cytoplasmic tails
ECE2 has a role in limiting Abeta (show APP Proteins) accumulation in the mouse brain
Endothelin-converting enzymes, such as ECE2 (EC 18.104.22.168), are type II metalloproteases that generate functionally pleiotropic members of the endothelin vasoactive peptide family (Lorenzo et al., 2001
endothelin converting enzyme 2
, endothelin-converting enzyme 2
, endothelin-converting enzyme 2 isoform 2a-1
, endothelin-converting enzyme 2 isoform 2a-2
, endothelin-converting enzyme 2 isoform 2b-1
, endothelin-converting enzyme 2 isoform 2b-2