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Involved in the regulation of glucose homestasis and lipid metabolism (By similarity). Additionally we are shipping Energy Homeostasis Associated Kits (25) and Energy Homeostasis Associated Proteins (4) and many more products for this protein.
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our data suggest that adropin is a membrane-bound protein that interacts with the brain-specific (show CALY Antibodies) Notch1 (show NOTCH1 Antibodies) ligand NB3 (show CNTN6 Antibodies).
Release of adropin in the fed condition regulates fuel selection in skeletal muscle, promoting glucose oxidation over fat oxidation. The molecular mechanisms of adropin's effects involve acetylation (suggesting inhibition) of the transcriptional co-activator PGC1alpha, reducing PDK4 (show PDK4 Antibodies) and CPT1B (show CPT1B Antibodies) activity. Increased PGC1alpha acetylation by adropin may be mediated by inhibiting Sirtuin-1 (SIRT1 (show SIRT1 Antibodies)), a PGC1alpha deacetylase.
Adropin has an endothelial protective function mediated via upregulation of eNOS (show NOS3 Antibodies) expression through the VEGFR2 (show KDR Antibodies)-PI3K-Akt (show AKT1 Antibodies) and VEGFR2 (show KDR Antibodies)-ERK1/2 (show MAPK1/3 Antibodies) pathways. Adropin therapy may thus be useful for limiting diseases characterized by endothelial dysfunction.
Adropin is the name given to the secreted peptide encoded by human C9orf165. In mice, it is abundant in liver where it is regulated by dietary macronutrients. Adropin regulates expression of genes involved in lipogenesis and adipogenesis.
Serum adropin concentrations are negatively associated with renal function.
High adropin expression is associated with polycystic ovary syndrome.
There were no significant differences among the groups of systemic sclerosis (SSc (show CYP11A1 Antibodies)) and controls in terms of ENHO gene expressions. There was no significant difference between the limited and diffuse cutaneous subtypes of SSc (show CYP11A1 Antibodies) in terms of serum adropin level and ENHO gene expression. Moreover, serum adropin level and ENHO gene expression were not associated with the disease activity and severity indexes.
Enho mutations plays a critical role in activating endothelial cells during neutrophil recruitment and neutrophil-endothelium cell interactions under IL-1 (show IL1A Antibodies) and TNF-alpha (show TNF Antibodies)-induced vascular inflammation and increases susceptibility to MPOANCA associated lung injury.
In HD patients, lower plasma adropin concentration is associated with dyslipidemia. Major homozygosity of RXRA (show RXRA Antibodies) seems to have an opposite effect on plasma adropin compared with that of ENHO rs2281997
Data suggest that serum adropin (ENHO) levels in normal, overweight, and obese adults negatively correlate with vascular stiffness (using common carotid artery) and adiposity (using abdominal visceral fat), and positively correlate with plasma nitric oxide levels (using nitrite/nitrate) and cardiorespiratory fitness; aerobic exercise training up-regulates serum adropin.
The adropin levels of metabolic syndrome, obesity, and control groups also showed no difference
Circulating adropin levels were determined lower in patients with endometrial cancer than in a control group.
Lipids originating either from the diet or from endogenous production appear to positively affect plasma adropin concentrations in humans.
Serum adropin levels were significantly lower in obese children; however, there was no correlation between serum adropin levels and blood pressure variables.
Involved in the regulation of glucose homestasis and lipid metabolism (By similarity).
, energy homeostasis-associated protein
, energy homeostasis associated
, energy homeostasis associated protein