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ELMO1 encodes a member of the engulfment and cell motility protein family. Additionally we are shipping ELMO1 Antibodies (65) and many more products for this protein.
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ELMO-DOCK1 (show DOCK1 Proteins), a bipartite guanine nucleotide exchange factor (show ARHGEF12 Proteins) complex for the small GTPase (show RACGAP1 Proteins) Rac1, and for the membrane-cytoskeletal linker Ezrin (show EZR Proteins), regulates centriole/basal body migration, docking and spacing.
ELMO1 is expressed in rheumatoid arthritis synovium, promotes cell migration and invasion, and regulates Rac1 activity, thereby mediating rheumatoid arthritis pathogenicity.
Src-mediated Y724 phosphorylation in ELMO1 plays a critical role for cell spreading via activation of Rac1, leading to promotion of cell migration.
high ELMO1 expression is an independent negative prognostic factor in normal karyotype (NK) acute myeloid leukemia (show BCL11A Proteins).
For ELMO1 (+9170 G>A), the GG genotype frequency was higher in the diabetic versus control group, but there were no differences between diabetic patients with and without nephropathies.
Thus, Elmo1 and Dock180 (show DOCK1 Proteins) facilitate blood vessel formation by stabilization of the endothelium during angiogenesis.
There is a low frequency rate of the ancestral genotype for the ELMO1 polymorphism rs1345365 in mestizos from the western and southeastern regions of Mexico.
High ELMO1 expression is associated with serous ovarian cancer.
the present study characterized a novel Nck-1-ELMO1 interaction and defined a new role for Nck-1 in regulating Rac1 activity.
findings reveal a previously unknown, nonredundant role for Elmo1 in controlling Dock2 levels and Dock2-dependent T cell migration in primary lymphocytes.
genetic association study in population in China: Data suggest that 2 SNPs in ELMO1 (rs741301; rs10951509) are associated with diabetic nephropathy in Chinese subjects with type 2 diabetes.
Elmo1 hypermorphs have albuminuria, glomerulosclerosis, and changes in the ultrastructure of the glomerular basement membrane that increase in severity in parallel with the expression of Elmo 1.
Src contributed to tyrosine phosphorylation of ELMO1 at Y720 and Y724 residues, which was crucial for activation of Rac1, followed by the promoting cell adhesion, spreading, and migration.
regulator of Med31 (show MED31 Proteins), revealing a previously unrecognized link between cytoplasmic signaling proteins and the Mediator complex
Data show that intracellular engulfment protein ELMO1 was required for phagocytosis by DCX (show DCX Proteins)(+) cells.
findings uncover a selective requirement for ELMO1 in Sertoli-cell-mediated removal of apoptotic germ cells and make a compelling case for a relationship between engulfment and tissue homeostasis in vivo
functional studies suggest that BAI1 (show BAI1 Proteins) cooperates with ELMO/Dock180 (show DOCK1 Proteins)/Rac (show AKT1 Proteins) to promote maximal engulfment of apoptotic cells
A novel signaling cascade is identified in which ELMO1/DOCK180 (show DOCK1 Proteins) regulates vasculature formation in zebrafish.
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein ced-12-like protein
, engulfment and cell motility protein 1
, engulfment and cell motility 1
, engulfment and cell motility protein 1-like
, ced-12 homolog 1
, engulfment and cell motility 1, ced-12 homolog
, engulfment and cell motility 1 splice 1