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The protein encoded by EHMT1 is a histone methyltransferase that is part of the E2F6 complex, which represses transcription.
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Human Monoclonal EHMT1 Primary Antibody for ELISA, WB - ABIN969480
De León, Crutchlow, Ham, Stoffers: Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus. in The international journal of biochemistry & cell biology 2006
Show all 2 references for ABIN969480
Human Monoclonal EHMT1 Primary Antibody for ELISA, WB - ABIN966204
Young: Inhibition of glucagon secretion. in Advances in pharmacology (San Diego, Calif.) 2006
Show all 2 references for ABIN966204
Selective degradation of the mutant EHMT1 mRNA leads to Kleefstra syndrome.
G9a (show EHMT2 Antibodies) and GLP (show RCBTB1 Antibodies) are required for stable maintenance of imprinted DNA methylation (show HELLS Antibodies) in embryonic stem cells.
the clinical picture we found in Norwegian patients with Kleefstra syndrome is similar to the findings described in the literature. An interesting point is that in the literature >85% of the patients have a deletion of 9q34.3 and the remaining have a mutation in the EHMT1 gene, whereas in this study we found 50% with a deletion, and 50% with a mutation.
Data indicate zinc finger proteins ZNF644 (show ZNF644 Antibodies) and WIZ (show ZNF803 Antibodies) as two core subunits in the histone-lysine N-methyltransferase G9a (show EHMT2 Antibodies)/GLP (show RCBTB1 Antibodies) complex, and interact with the transcription activation domain of G9a (show EHMT2 Antibodies) and GLP (show RCBTB1 Antibodies).
data provide genetic and pharmacologic evidence that EHMT1 and EHMT2 (show EHMT2 Antibodies) are epigenetic regulators involved in gamma-globin (show HBG1 Antibodies) repression and represent a novel therapeutic target for SCD (show SCD Antibodies).
The expression level of EHMT1 and EHMT2 (show EHMT2 Antibodies) inversely correlates with the type I interferon (show IFNA Antibodies) responsiveness in chronic myeloid leukemia (show BCL11A Antibodies) cell lines.
The current knowledge on the mechanisms of action and function of EHMT1, with particular emphasis on their interplay in the regulation of chromatin states and biological processes.
Haploinsufficiency of EHMT1 caused by either microdeletions at 9q34.3 or intragenic mutations are associated with Kleefstra syndrome.
PRC2 and G9a (show EHMT2 Antibodies)/GLP (show RCBTB1 Antibodies) interact physically and functionally.
Data indicate that Kleefstra syndrome patient carrying a splice-site mutation in EHMT1 inherited from the mother who showed tissue-specific mosaicism.
The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome). Two transcript variants encoding different isoforms have been found for this gene.
G9a like protein
, G9a-like protein 1
, H3-K9-HMTase 5
, histone H3-K9 methyltransferase 5
, histone-lysine N-methyltransferase EHMT1
, histone-lysine N-methyltransferase, H3 lysine-9 specific 5
, lysine N-methyltransferase 1D