Eukaryotic Translation Elongation Factor 1 alpha 2 Proteins (EEF1A2)

EEF1A2 encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. Additionally we are shipping EEF1A2 Antibodies (70) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EEF1A2 1917 Q05639
EEF1A2 13628 P62631
EEF1A2 24799 P62632
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Top EEF1A2 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,303.67
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,303.67
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EEF1A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Eukaryotic Translation Elongation Factor 1 alpha 2 (EEF1A2) Interaction Partners

Human Eukaryotic Translation Elongation Factor 1 alpha 2 (EEF1A2) interaction partners

  1. eEF1A2 is highly expressed in hepatocellular carcinoma. Its silencing significantly decreases HCC (show FAM126A Proteins) tumorigenesis, likely by inhibiting PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling.

  2. Differential gene expression analysis demonstrated significant upregulation of PDZK1IP1, EEF1A2 and RPL41 (ENSG00000279483) genes in the intrahepatic cholangiocarcinoma samples when compared with the matched paratumor samples.

  3. In both cases, a de novo recurrent heterozygous mutation in EEF1A2 [c.364G>A (p.E122K)] was identified by whole-exome sequencing. CONCLUSION: This report provides clinical data on epileptic encephalopathy in patients with EEF1A2 mutation. Continuous high-voltage delta activity seen over both parietal areas may be a unique manifestation of EEF1A2 mutation.

  4. Our results provide novel information on the intracellular distribution and interaction of eEF1A (show EEF1A1 Proteins) isoforms.

  5. By directly targeting eEF1A2.

  6. Both eEF1A1 (show EEF1A1 Proteins) and eEF1A2 colocalise with all eEF1B (show EEF1B2 Proteins) subunits, in such close proximity that they are highly likely to be in a complex.

  7. De novo EEF1A2 mutations in patients with characteristic facial features, intellectual disability, autistic behaviors and epilepsy.

  8. Finally, a strong association between the expression of EEF1A2, phosphorylated AKT (show AKT1 Proteins) and MDM4 (show MDM4 Proteins) was observed in human HCC (show FAM126A Proteins) samples. Strong activation of the EEF1A2/PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins)/MDM4 (show MDM4 Proteins) signaling pathway was observed in HCC (show FAM126A Proteins) patients

  9. Overexpression of eEF1A2 was correlated with worse outcomes in gastric cancer patients, suggesting its critical roles in the carcinogenesis of gastric cancer.

  10. miR (show MLXIP Proteins)-663 and miR (show MLXIP Proteins)-744 mediate inhibition of the proto-oncogene (show RAB1A Proteins) eEF1A2 expression that results in retardation of the MCF7 cancer cells proliferation. We also observed upregulation of miR (show MLXIP Proteins)-663 and miR (show MLXIP Proteins)-744 with corresponding downregulation of eEF1A2 in resveratrol-treated MCF7 cells, suggesting that resveratrol may influence eEF1A2 expression through a miRNA-dependent pathway.

Mouse (Murine) Eukaryotic Translation Elongation Factor 1 alpha 2 (EEF1A2) interaction partners

  1. This provides the first in vivo confirmation that eEF1A2 plays an important role in translation.

  2. Heterozygous mutant mice showed no deficit in neuromuscular function or signs of spinal cord pathology, in spite of the low levels of eEF1A2

  3. In-depth analysis using site-directed mutagenesis revealed that PKCbetaI could phosphorylate Ser (show SIGLEC1 Proteins)(3) of the eEF1A2 isoform and that the association between eEF1A2 and PKCbetaI was dependent on the phosphorylation status of eEF1A2

  4. EEF1A2 may play contribute to the induction or progression of some plasmacytomas and a small percentage of multiple myeloma.

  5. these results suggest an important role for eEF1A2 in driving cap-independent translation of utrophin A in skeletal muscle.

  6. expression of eEF1A-2/S1 protein is activated upon myogenic differentiation

  7. This is a putative oncogene (show RAB1A Proteins) in ovarian cancer.

  8. Data suggest that spontaneous failure of eEF1A2 expression in the wasted mutant first triggers gliosis in spinal cord and retraction of motor nerve terminals in muscle, and then motor neuron pathology and death.

  9. eEF1A-2 interacts with Prdx-I to functionally provide cells with extraordinary resistance to oxidative stress-induced (show SQSTM1 Proteins) cell death[eEF1A-2 and Prdx-I]

  10. The above findings suggest that an increase in free-form eEF1A under alkaline conditions plays a critical role in alkalinization-induced cell growth.

Rabbit Eukaryotic Translation Elongation Factor 1 alpha 2 (EEF1A2) interaction partners

  1. the interaction of eEF1A with two known partners - calmodulin and actin

  2. eEF1A2 crystals obtained using ammonium sulfate as precipitant diffracted to 2.5 A resolution and belonged to space group P6(1)22 or P6(3)22 (unit-cell parameters a = b = 135.4, c = 304.6 A).

EEF1A2 Protein Profile

Protein Summary

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with EEF1A2

  • eukaryotic translation elongation factor 1 alpha 2 (EEF1A2)
  • eukaryotic translation elongation factor 1 alpha 1 (EEF1A1)
  • eukaryotic translation elongation factor 1 alpha 2 (Eef1a2)
  • eukaryotic translation elongation factor 1 alpha 2 S homeolog (eef1a2.S)
  • eukaryotic translation elongation factor 1 alpha 2 (eef1a2)
  • putative elongation factor 1-alpha-like 3 (LOC739210)
  • eukaryotic translation elongation factor 1 alpha 2 (EEF1)
  • eukaryotic translation elongation factor 1 alpha 2 (eef1)
  • Eef1a protein
  • EEF1A-2 protein
  • EEF1A2 protein
  • eef1al protein
  • EF-1-alpha-2 protein
  • ef1a protein
  • HS1 protein
  • Ps10 protein
  • RATPS10 protein
  • S1 protein
  • STN protein
  • stnl protein
  • wasted protein
  • wst protein
  • zgc:92085 protein

Protein level used designations for EEF1A2

eEF1A-2 , elongation factor 1-alpha 2 , elongation factor-1 alpha , eukaryotic elongation factor 1 A-2 , statin S1 , statin-S1 , elongation factor 1-alpha 1 , eukaryotic translation elongation factor 1 alpha 2 , EF-1-alpha-2 , Statin-like protein , elongation factor 1 A-2 , ef-1-alpha-2 , elongation factor 1 A2 , LOW QUALITY PROTEIN: elongation factor 1-alpha 2

GENE ID SPECIES
1917 Homo sapiens
403506 Canis lupus familiaris
13628 Mus musculus
24799 Rattus norvegicus
380550 Xenopus laevis
419244 Gallus gallus
496898 Xenopus (Silurana) tropicalis
515233 Bos taurus
739210 Pan troglodytes
5727887 Chlamydomonas reinhardtii
9620997 Volvox carteri f. nagariensis
100008677 Oryctolagus cuniculus
100025136 Monodelphis domestica
100549386 Meleagris gallopavo
436644 Danio rerio
100731897 Cavia porcellus
100060464 Equus caballus
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