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EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002 [PubMed 12133843]).[supplied by OMIM, Mar 2008].. Additionally we are shipping EIF2A Antibodies (77) and EIF2A Kits (2) and many more products for this protein.
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Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors.
in mouse skeletal muscle stem cells, general repression of translation, mediated by the phosphorylation of translation initiation factor (show TIF1 Proteins) eIF2alpha at serine 51 (P-eIF2alpha), is required to maintain the quiescent state
Skeletal muscle-specific (show EIF3K Proteins) eukaryotic translation initiation factor 2alpha (show EIF2S1 Proteins) phosphorylation controls amino acid metabolism and fibroblast growth factor 21 (show FGF21 Proteins)-mediated non-cell-autonomous energy metabolism.
These experiments connect embryonic stem cell growth factors to eIF2alpha phosphorylation.
PGRN (show GRN Proteins) is a key regulator of insulin (show INS Proteins) resistance and PGRN (show GRN Proteins) may mediate its effects, at least in part, by inducing ER stress via the PERK (show EIF2AK3 Proteins)-eIF2alpha dependent pathway
The CARE-LUC mouse model represents an innovative tool to investigate the eIF2alpha-ATF4 (show ATF4 Proteins) axis and to develop drugs targeting this important pathway in the remediation of related pathologies.
inhibition of eIF2alpha and FAK (show PTK2 Proteins) signaling may play an important role in cigarette smoking-induced lung EC apoptosis and emphysema
eIF2a phosphorylation is required for the normal function of intestinal Paneth cells and mucosal homeostasis.
Hypothalamic eIF2alpha phosphorylation could play a critical role in the onset of anorexia associated with certain diseases.
The pathogenesis of cardiomyopathy in Frederich ataxia (show USP14 Proteins) correlates with the early and persistent eIF2alpha phosphorylation.
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
GHRH (show GHRH Proteins) and GHRH-R (show GHRHR Proteins) loops are involved in placental choriocarcinoma cell line viability and apoptosis through Akt (show AKT1 Proteins) and eIF2a (show EIF2S1 Proteins) pathways.
These findings suggest that phosphorylated-eIF2alpha regulates synaptic actions of nicotine in both mice and humans, and that reduced phosphorylated-eIF2alpha may enhance susceptibility to nicotine (and other drugs of abuse) during adolescence.
The results suggest that dephosphorylation of eIF2a (show EIF2S1 Proteins) by GADD34 (show PPP1R15A Proteins) plays an important role in doxorubicin resistance of MCF-7/ADR (show AKR1B1 Proteins) cells.
The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a (show EIF2S1 Proteins), which is mediated by continual activation of PKR (show PKLR Proteins) and degradation of PP1 (show PPA1 Proteins).
We identified EIF2A (show EIF2S1 Proteins) phosphorylation as a novel early molecular event occurring in response to NAMPT (show NAMPT Proteins) inhibition and mediating protein synthesis arrest.
analysis of the ER stress response in immunogenic cell death and the potential value of eIF2alpha phosphorylation as a biomarker for this clinically relevant variant of apoptosis [review]
The data highlight independent interactions of PP1 (show PPA1 Proteins) and eIF2alpha with GADD34 (show PPP1R15A Proteins), demonstrating that GADD34 (show PPP1R15A Proteins) functions as a scaffold both in vitro and in cells
hypusine-eIF5A (show EIF5 Proteins)-facilitated translation elongation promotes arsenite-induced polysome disassembly and stress granule assembly in cells subjected to adverse environmental conditions
There was no statistically significant difference in IFN therapeutic effectiveness among the patients with different genotypes of eIF-2a (show EIF2S1 Proteins)-reg2 (show FLOT1 Proteins).
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
eukaryotic translation initiation factor 2A, 65kDa
, eukaryotic translation initiation factor
, eukaryotic translation initiation factor 2A-like
, 65 kDa eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A