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Eukaryotic Translation Initiation Factor 2B, Subunit 5 Epsilon, 82kDa Proteins (EIF2B5)

EIF2B5 encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Additionally we are shipping EIF2B5 Antibodies (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF2B5 224045 Q8CHW4
Rat EIF2B5 EIF2B5 192234 Q64350
EIF2B5 8893 Q13144
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Top EIF2B5 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

EIF2B5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Eukaryotic Translation Initiation Factor 2B, Subunit 5 Epsilon, 82kDa (EIF2B5) Interaction Partners

Mouse (Murine) Eukaryotic Translation Initiation Factor 2B, Subunit 5 Epsilon, 82kDa (EIF2B5) interaction partners

  1. analysis of eukaryotic initiation factor 2B epsilon phosphorylation sites and ubiquitin-modified lysine residues

  2. Data show that toll (show TLR4 Proteins)-like receptors (TLRs)-TRIF (show RNF138 Proteins) signalling activates eIF2B (show EIF2B4 Proteins) GEF (show ARHGEF2 Proteins) through PP2A (show PPP2R2B Proteins)-mediated serine dephosphorylation of the eIF2B (show EIF2B4 Proteins) varepsilon-subunit.

  3. mouse model of EIF2B (show EIF2B4 Proteins)-related leukodystrophy; findings provide evidence that hypomorphic Eif2b5 alleles lead to delayed and abnormal development and maintenance of CNS white matter

  4. Inhibition of pancreatic protein synthesis in this model of acute pancreatitis most likely results from inhibition of translation initiation from increased eIF2alpha (show EIF2A Proteins) phosphorylation, reduction of eIF2B (show EIF2B4 Proteins) activity, and inhibition of eIF4F (show EIF4A2 Proteins) complex formation.

  5. inactivation of glycogen synthase kinase 3beta (GSK3beta) by high glucose and high insulin (show INS Proteins) induces increase in synthesis of laminin beta1 via activation of eIF2Bepsilon.

Human Eukaryotic Translation Initiation Factor 2B, Subunit 5 Epsilon, 82kDa (EIF2B5) interaction partners

  1. This study demonstrated that no evidence for a role of Ile587Val polymorphism of EIF2B5 gene in multiple sclerosis in Kashmir Valley if India.

  2. Patient exhibits an early-infantile onset and progressive disease course resembling Cree leukoencephalopathy, suggesting a severe functional disruption of eIF2Bepsilon caused by R195H as well as by I408T mutations.

  3. Missense mutations in EIF2B5 are associated with multiple sclerosis.

  4. Also a mutation c.1913G>A[p.Arg638 His] in exon 14 of the EIF2B5-Gens as single nucleotide polymorphism.

  5. crystal structure of the guanine nucleotide exchange factor (show RASGRF1 Proteins) for elf2 (show ELF2 Proteins)

  6. Functional analysis of recently identified mutations in eukaryotic translation initiation factor (show EIF2A Proteins) 2Bepsilon (eIF2Bepsilon) identified in Chinese patients with vanishing white matter disease

  7. Cree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locus.

  8. Mutation in EIF2B5 causes childhood ataxia (show USP14 Proteins) with central nervous system hypomyelination/ vanishing white matter leukodystrophy.

  9. We demonstrated that mutations in the gene EIF2B5 cause "leukoencephalopathy with vanishing white matter." This gene encodes one of the five subunits of the translation factor eIF2B (show EIF2B1 Proteins).

  10. Biochemical analyses indicate that mutations analyzed in eIF2Balpha and -epsilon reduce the steady-state level of the affected subunit, while the most severe mutant tested, eIF2Bbeta(V341D), forms complexes with reduced stability and lower eIF2B (show EIF2B1 Proteins) activity.

EIF2B5 Protein Profile

Protein Summary

This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.

Gene names and symbols associated with EIF2B5

  • eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa (EIF2B5)
  • trimeric LpxA-like enzyme (AT2G34970)
  • trimeric LpxA-like enzyme (AT3G02270)
  • translation initiation factor eif-2b epsilon subunit (AOR_1_624154)
  • translation initiation factor eIF-2B epsilon subunit (CTRG_05484)
  • translation initiation factor eIF-2B epsilon subunit (PAAG_05066)
  • translation initiation factor eIF-2B epsilon subunit (CGB_A5380C)
  • translation initiation factor eif-2b epsilon subunit (TERG_01115)
  • eukaryotic translation initiation factor 2B, subunit 5 epsilon (Eif2b5)
  • AO090003000364 protein
  • C81315 protein
  • CACH protein
  • CLE protein
  • EIF-2B protein
  • EIF2B5 protein
  • EIF2Bepsilon protein
  • F14P3.8 protein
  • F14P3_8 protein
  • F19I3.20 protein
  • F19I3_20 protein
  • LVWM protein

Protein level used designations for EIF2B5

eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa , translation initiation factor eIF-2B subunit epsilon , translation initiation factor eIF-2B subunit epsilon-like , translation initiation factor eIF-2B epsilon subunit , translation initiation factor eif-2b epsilon subunit , eIF-2B GDP-GTP exchange factor subunit epsilon , initiation factor eIF-2Be , eIF-2Bepsilon

GENE ID SPECIES
424948 Gallus gallus
460881 Pan troglodytes
488103 Canis lupus familiaris
703673 Macaca mulatta
783760 Bos taurus
100389722 Callithrix jacchus
100446186 Pongo abelii
100580454 Nomascus leucogenys
818061 Arabidopsis thaliana
821200 Arabidopsis thaliana
5991536 Aspergillus oryzae RIB40
8300542 Candida tropicalis MYA-3404
9096172 Paracoccidioides sp. 'lutzii' Pb01
10187846 Cryptococcus gattii WM276
10373875 Trichophyton rubrum CBS 118892
224045 Mus musculus
192234 Rattus norvegicus
8893 Homo sapiens
100009393 Oryctolagus cuniculus
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