Eukaryotic Translation Initiation Factor 4 gamma 2 Proteins (EIF4G2)

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. Additionally we are shipping EIF4G2 Antibodies (116) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF4G2 1982 P78344
EIF4G2 13690 Q62448
Rat EIF4G2 EIF4G2 361628  
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Top EIF4G2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$2,091.83
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EIF4G2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2) Interaction Partners

Zebrafish Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2) interaction partners

Xenopus laevis Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2) interaction partners

Human Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2) interaction partners

  1. DAP5 knockdown from human ESCs (show NR2E3 Proteins) (hESCs) resulted in persistence of pluripotent gene expression, delayed induction of differentiation-associated genes in different cell lineages, and defective embryoid body formation

  2. Data show that microRNA miR (show MLXIP Proteins)-379 potentiated lung cancer (LCa (show CLTA Proteins)) chemosensitivity via modulation of cisplatin (CDDP)-induced apoptosis by directly targeting the eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) 3' UTR.

  3. These results indicate that miR (show MLXIP Proteins)-139 is capable of inhibiting chondrocyte proliferation and migration, thus being a possible therapeutic target for OA. The mechanism of miR (show MLXIP Proteins)-139 in chondrocytes may be related to its regulation on EIF4G2 and IGF1R (show IGF1R Proteins).

  4. The Coxsackievirus B3 protease 2A-mediated cleavage of DAP5 results in the production of two truncates that exert differential effects on protein translation of the IRES-containing genes, leading to enhanced host cell death.

  5. Knockdown of EIF4G2 recapitulated the effects of mir (show MLXIP Proteins)-139, whereas restoring EIF4G2 expression rescued the mir (show MLXIP Proteins)-139 phenotype. elevated miR (show MLXIP Proteins)-139-5p expression is associated with a favorable outcome in acute myeloid leukemia (show BCL11A Proteins).

  6. findings provide the first mechanistic insights into the function of DAP5 as a selective regulator of cap-independent translation

  7. Our results provide evidence that the tumor suppressor effect of miR (show MLXIP Proteins)-520c-3p is mediated through repression of translation while inducing senescence and that eIF4GII (show EIF4G3 Proteins) is a key effector of this anti-tumor activity.

  8. DAP5, a translation initiation factor (show TIF1 Proteins) shown to positively regulate the translation of various internal ribosome entry sites containing mRNAs, promotes internal ribosome entry site-driven translation of p53 (show TP53 Proteins) mRNA.

  9. DAP5/p97 and DAP5/p86 enhanced the translation of the anti-apoptotic protein Bcl-2 (show BCL2 Proteins) and inhibited cisplatin-induced apoptosis

  10. Multiple isoforms of eIF4GII (show EIF4G3 Proteins) arise from multiple promoters & alternative splicing events. A non-canonical CUG initiation codon extends the eIF4GII (show EIF4G3 Proteins) N-terminus. The eIF4GII (show EIF4G3 Proteins) N-terminus plays an alternative role in initiation factor assembly.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2) interaction partners

  1. analysis of the tandem MA-3 (show PDCD6 Proteins) region of Pdcd4 (show PDCD4 Proteins) protein and characterization of its interactions with eIF4A (show EIF4A1 Proteins) and eIF4G (show EIF4G1 Proteins)

EIF4G2 Protein Profile

Protein Summary

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3\; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

Gene names and symbols associated with EIF4G2

  • eukaryotic translation initiation factor 4, gamma 2b (eif4g2b)
  • eukaryotic translation initiation factor 4 gamma, 2 (EIF4G2)
  • eIF4G-related protein NAT1 (nat1)
  • eukaryotic translation initiation factor 4, gamma 2 (Eif4g2)
  • AA589388 protein
  • AAG1 protein
  • DAP-5 protein
  • DAP5 protein
  • E130105L11Rik protein
  • EIF4G2 protein
  • hm:zeh1307 protein
  • Nat1 protein
  • NAT1B protein
  • Natm1 protein
  • P97 protein
  • wu:fa14h01 protein
  • wu:fb44h01 protein
  • wu:fb59c06 protein
  • wu:fc21b05 protein

Protein level used designations for EIF4G2

eukaryotic translation initiation factor 4 gamma, 2 , fb44h01 , eukaryotic translation initiation factor 4 gamma 2 , Eukaryotic translation initiation factor 4 gamma 2 , DAP-5 , aging-associated protein 1 , death-associated protein 5 , eIF-4-gamma 2 , eIF-4G 2 , eIF4G 2 , eukaryotic translation initiation factor 4G-like 1 , eIF4G-related protein NAT1 , p97 , novel APOBEC-1 target 1 , translation repressor NAT1 , translation repressor Nat1

GENE ID SPECIES
334618 Danio rerio
466443 Pan troglodytes
705510 Macaca mulatta
100173304 Pongo abelii
496405 Xenopus laevis
1982 Homo sapiens
395905 Gallus gallus
476854 Canis lupus familiaris
286870 Bos taurus
100009236 Oryctolagus cuniculus
13690 Mus musculus
361628 Rattus norvegicus
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