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ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. Additionally we are shipping EIF4A2 Antibodies (91) and EIF4A2 Kits (4) and many more products for this protein.
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eIF4A2 is recruited to stress granules, suggesting sumoylation of eIF4A2 correlates with its recruitment to stress granules.
Studies indicate a developing focus on targeting eukaryotic initiation factor 4A (show DDX39 Proteins) eIF4A1 (show EIF4A1 Proteins) and eIF4A2 as cancer therapy.
These data support a linear model for miRNA-mediated gene regulation in which translational repression via eIF4A2 is required first, followed by mRNA destabilization.
The results indicated that eIF4AI and eIF4AII expression are linked and that the two protein isoforms exhibit functional differences.
Studies indicate that eIF4A (DDX2), together with its accessory proteins eIF4B and eIF4H, is thought to act as a helicase that unwinds secondary structures in the mRNA 5' UTR.
Single nucleotide polymorphisms in two relevant candidate genes for glucose homeostasis, kininogen (KNG1 (show KNG1 Proteins)), and eukaryotic translation initiation factor (show EIF2A Proteins) 4alpha2 (EIF4A2) linked to type 2 diabetes.
subcellular distribution of eIF4F components may potentiate the complex assembly
A feedforward loop involving c-Myc (show MYC Proteins) and eIF4F that serves to link transcription and translation and that could contribute to the effects of c-Myc (show MYC Proteins) on cell proliferation and neoplastic growth.
complete sequence of the porcine EIF4A2 gene, its predicted amino acid sequence, genomic structure, expression patterns, and single nucleotide polymorphisms
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
eukaryotic initiation factor 4A-II
, eukaryotic translation initiation factor 4A
, eukaryotic translation initiation factor 4A2
, eukaryotic translation initiation factor 4A, isoform 2
, protein synthesis initiation factor 4AII
, ATP-dependent RNA helicase eIF4A-2
, translational eukaryotic inititation factor 4AII