Eukaryotic Translation Initiation Factor 4E Proteins (EIF4E)

The protein encoded by EIF4E is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. Additionally we are shipping EIF4E Antibodies (259) and EIF4E Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF4E 1977 P06730
EIF4E 13684 P63073
EIF4E 117045 P63074
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Top EIF4E Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 4 Days
$522.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 15 to 16 Days
$300.00
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,526.33
Details
Yeast Aplysia californica His tag   1 mg Log in to see 60 to 71 Days
$2,531.83
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,535.50
Details

EIF4E Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced EIF4E Proteins

  1. Human EIF4E Protein expressed in Wheat germ - ABIN1352595 : Andrieu, Taieb, Baylot, Ettinger, Soubeyran, De-Thonel, Nelson, Garrido, So, Fazli, Bladou, Gleave, Iovanna, Rocchi: Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E. in Oncogene 2010 (PubMed)

More Proteins for Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaction Partners

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. The structures of eIF4E-eIF4G (show EIF4G1 Proteins) complexes reveal an extended interface to regulate translation initiation.

  2. Phosphorylation of 4E-BP1 (show EIF4EBP1 Proteins) impairs the competition with eIF4G (show EIF4G1 Proteins) for eIF4E binding.

  3. Both eIF4E-1 and eIF4E-3 (show EIF4E3 Proteins) are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.

  4. eIF4E-binding protein (show EIF4EBP1 Proteins) requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.

  5. Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.

  6. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.

  7. eIF4E regulates the sex-specific expression of the master switch gene Sxl.

  8. data are consistent with the idea that Parkin (show PARK2 Proteins) and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events.

  9. results show that LK6 binds to ERK (show MAPK1 Proteins) and is activated by ERK (show MAPK1 Proteins) signalling and it is responsible for phosphorylating eIF4E in Drosophila

  10. our results suggest that the level of eIF4E protein is regulated by Diap1 (show DIAPH1 Proteins), and that IAPs may play a role in cap-dependent translation by regulating the level of eIF4E protein.

Xenopus laevis Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Pumilio 2 (show PUM2 Proteins) controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.

  2. CDK1 (show CDK1 Proteins) and calcineurin regulate Maskin (show TACC3 Proteins) association with eIF4E and translational control of cell cycle progression

  3. CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T (show EIF4ENIF1 Proteins) and eIF4E1b (show EIF4E1B Proteins)

Human Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Study identified and established the presence of an evolutionarily conserved water-bridge structural module which is an integral component of the recognition of the 5' mRNA cap by eIF4E during the process of translation initiation.

  2. Here, the authors identify the domains responsible for the eIF4E/human rhinovirus 2 2A(pro) interaction using molecular modelling and describe mutations that impair this interaction and delay in vitro cleavage of eIF4G (show EIF4G1 Proteins) isoforms.

  3. Results suggest that IGF2BP3 promotes eIF4E-mediated translational activation through the reduction of EIF4E-BP2 via mRNA degradation, leading to enhanced cell proliferation.

  4. There were significantly higher expressions of p-eIF4E and p-4EBP-1 (show EIF4EBP1 Proteins) proteins in the cases with lymph node metastasis than in those without lymph node metastasis.

  5. Our studies provide the first biochemical framework for the eIF4E-dependent mRNA export pathway.

  6. Human endogenous eIF4E1 and eIF4E2 (show EIF4E2 Proteins) behave under stresses similarly as their GFP-tagged counterparts.

  7. High EIF4E expression is associated with malignant peripheral nerve sheath tumors and vestibular schwannomas.

  8. The structures of eIF4E-eIF4G (show EIF4G1 Proteins) complexes reveal an extended interface to regulate translation initiation.

  9. 4E-BP1 (show EIF4EBP1 Proteins) has tumor suppressor activity by inhibiting eIF4E and, thus, blocking mRNA translation and proliferation. This is corroborated by elevated levels of phosphorylated and hence inactive 4E-BP1 (show EIF4EBP1 Proteins), which are detected in various cancers

  10. The studies suggest that MNK (show ATP7A Proteins)-eiF4E axis controls the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, CYFIP1 (show CYFIP1 Proteins). (Review)

Mouse (Murine) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Our work demonstrates that a single phosphorylation site on the 5' cap-binding protein eIF4E is a critical mechanism for changes in nociceptor excitability that drive the development of chronic pain.

  2. data suggest a physiological role for MNK1a-Ser (show SIGLEC1 Proteins)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.

  3. Results of our study suggest that the eIF4E/Fmr1 (show FMR1 Proteins) double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder.

  4. Our findings identify the eIF4E- beta-catenin (show CTNNB1 Proteins) axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.

  5. Unphosphorylated HSP27 (show HSPB1 Proteins) associates with eIF4E in osteoblasts and suppresses the translation initiation process.

  6. Rotenone induction of hydrogen peroxide inhibits mTOR (show FRAP1 Proteins)-mediated S6K1 (show RPS6KB1 Proteins) and 4E-BP1 (show EIF4EBP1 Proteins)/eIF4E pathways, resulting in caspase (show CASP3 Proteins)-dependent and -independent apoptosis in neuronal cells.

  7. Findings indicate eIF4E is maintained at levels in excess (show RCC1 Proteins) for normal development that are hijacked by cancer cells to drive a translational program supporting tumorigenesis.

  8. a light- and circadian clock-regulated MAPK (show MAPK1 Proteins)/MNK (show ATP7A Proteins) pathway led to phosphorylation of the cap-binding protein eIF4E

  9. mice in which eukaryotic translation initiation factor 4E (eIF4E) cannot be phosphorylated are resistant to lung metastases in a mammary tumor model, and cells isolated from these mice exhibit impaired invasion.

  10. Data suggest that MAP kinase (show MAPK1 Proteins)-interacting kinases (Mnk1 (show MKNK1 Proteins), Mnk2 (show MKNK2 Proteins)) regulate cell migration/wound healing, expression of vimentin (show VIM Proteins), stability of vimentin (show VIM Proteins) protein, and binding of eIF4E and Cyfip1 (cytoplasmic FMR1 interacting protein 1 (show CYFIP1 Proteins)).

Pig (Porcine) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. These data suggest that sapovirus VPg can hijack the cellular translation initiation mechanism by recruiting the eIF4F (show EIF4A2 Proteins) complex through a direct eIF4E interaction

  2. it is proposed that a balanced regulation of the truncation of the cap-binding complex component eIF4F (show EIF4A2 Proteins) and degradation of 4E-BP1 (show EIF4EBP1 Proteins) and/or truncation of 4E-BP2 (show EIF4EBP2 Proteins) that together ensures correct translational control during the dynamic process of conceptus implantation

  3. Results show that in pigs, the truncated eIF4E is located in the endometrial luminal epithelium during implantation. Neither glandulary tissue nor stroma expressed any truncated eIF4E.

  4. The translation initiation in the endometrium is differently regulated by the two eIF4E forms with regard to different 4E-BP1 (show EIF4EBP1 Proteins) abundance and phosphorylation as well as different eIF4E/4E-BP1 (show EIF4EBP1 Proteins) binding dynamic depending on the type of implantation.

  5. Modified translational initiation of eIF4E may particularly regulate protein synthesis during conceptus attachment at the time of implantation in swine.

  6. Translation initiation factor eIF4E is phosphorylated during in vitro maturation of pig oocytes with a maximum in metaphase II stage oocytes.

EIF4E Protein Profile

Protein Summary

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with EIF4E

  • Eukaryotic initiation factor 4E (eIF-4E)
  • eucaryotic initiation factor6 (eif6)
  • eukaryotic translation initiation factor 4E (eif4e)
  • eIF-4E protein (eif4e)
  • eukaryotic translation initiation factor 4E (EIF4E)
  • eukaryotic translation initiation factor 4E (Eif4e)
  • eukaryotic translation initiation factor 4ea (eif4ea)
  • translation initiation factor eIF4E (LOC100533326)
  • 2 protein
  • 0260/09 protein
  • 0587/11 protein
  • 0589/11 protein
  • 0919/12 protein
  • 1004/13 protein
  • 7238 protein
  • AUTS19 protein
  • cbp protein
  • CG4035 protein
  • CT13384 protein
  • CT39424 protein
  • CT39426 protein
  • D-eIF4E protein
  • deIF-4E protein
  • deIF4E protein
  • Dmel\\CG4035 protein
  • EG668879 protein
  • EIF-4E protein
  • eIF-4E1 protein
  • eIF-4E2 protein
  • eIF-4EII protein
  • eif4e protein
  • eIF 4E protein
  • eif4e-1 protein
  • eIF4E-1/2 protein
  • eIF4E-2 protein
  • Eif4e-ps protein
  • EIF4E1 protein
  • eIF4EI protein
  • EIF4EL1 protein
  • EIF4F protein
  • If4e protein
  • l(3)07238 protein
  • l(3)67Af protein
  • l(3)S025007 protein
  • l(3)S026009 protein
  • l(3)S058711 protein
  • l(3)S091912 protein
  • zgc:86680 protein

Protein level used designations for EIF4E

CG4035-PA , CG4035-PB , CG4035-PC , CG4035-PD , CG4035-PE , CG4035-PF , CG4035-PG , CG4035-PH , CG4035-PI , cap binding protein , eIF-4E-PA , eIF-4E-PB , eIF-4E-PC , eIF-4E-PD , eIF-4E-PE , eIF-4E-PF , eIF-4E-PG , eIF-4E-PH , eIF-4E-PI , eukaryotic initiation factor 4E , eukaryotic translation initiation factor 4E , lethal(3)67Af , eucaryotic initiation factor6 , eIF4E , PCO081734 , PCO081734_ov , mRNA cap-binding protein , eukaryotic translation initiation factor small subunit , eIF-4F 25 kDa subunit , eIF-4E , eukaryotic translation initiation factor 4E-like 1 , elongation initiation factor 4E , eukaryotic translation initiation factor 4e 1a , eukaryotic translation initiation factor eIF4E-1

GENE ID SPECIES
45525 Drosophila melanogaster
542608 Zea mays
548663 Xenopus (Silurana) tropicalis
399255 Xenopus laevis
1977 Homo sapiens
13684 Mus musculus
117045 Rattus norvegicus
422703 Gallus gallus
734259 Xenopus laevis
281751 Bos taurus
100009338 Oryctolagus cuniculus
487870 Canis lupus familiaris
100038030 Sus scrofa
79380 Danio rerio
100533326 Aplysia californica
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