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The protein encoded by EIF4ENIF1 is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. Additionally we are shipping EIF4ENIF1 Proteins (3) and many more products for this protein.
Showing 10 out of 94 products:
Human Polyclonal EIF4ENIF1 Primary Antibody for ICC, IF - ABIN4307653
Martínez, Sesé, Losa, Robichaud, Sonenberg, Aasen, Ramón Y Cajal: Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. in PLoS ONE 2015
Show all 2 Pubmed References
Human Polyclonal EIF4ENIF1 Primary Antibody for IF, WB - ABIN527919
Yang, Smibert, Kaplan, Miller: An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. in Neuron 2014
Show all 2 Pubmed References
Human Polyclonal EIF4ENIF1 Primary Antibody for IHC (p), IHC - ABIN250125
Dostie, Ferraiuolo, Pause, Adam, Sonenberg: A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. in The EMBO journal 2000
Human Polyclonal EIF4ENIF1 Primary Antibody for ICC, IF - ABIN4307652
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
we demonstrate that joint deletion of two short conserved motifs that bind UNR (show P2RY4 Antibodies) and DDX6 (show DDX6 Antibodies) relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6 (show DDX6 Antibodies)-CNOT1 (show CNOT1 Antibodies) axis.
our data support a model where 4E-T promotes mRNA turnover by physically linking the 3'-terminal mRNA decay machinery to the 5' cap
neural precursors are transcriptionally primed to generate neurons, but an eIF4E (show EIF4E Antibodies)/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis.
that while both eIF4E1 (show EIF4E Antibodies) and eIF4E2 (show EIF4E2 Antibodies) bind 4E-T via the canonical YX 4Lvarphi sequence, nearby downstream sequences also influence eIF4E (show EIF4E Antibodies):4E-T interactions
This work has demonstrated the conserved yet unpredicted and surprising translational control of bound mRNAs by 4E-T, which does not involve eIF4E (show EIF4E Antibodies), nor P-body components.
Data demonstrate that EIF4ENIF1 is associated with dominantly inherited primary ovarian insufficiency.
The c-Jun N-terminal kinase (JNK) is targeted to processing bodies in response to oxidative stress and promotes the phosphorylation of 4E-T.
human P bodies contain the cap-binding protein eIF4E (show EIF4E Antibodies) and the related factor eIF4E-transporter (eIF4E (show EIF4E Antibodies)-T), suggesting novel roles for these proteins in targeting mRNAs for 5' --> 3' degradation
A role for the eIF4E-binding protein (show NGDN Antibodies) 4E-T in P-body formation and mRNA decay is described.
Overexpression of eIF4E (show EIF4E Antibodies)-T triggers the movement of eIF4E (show EIF4E Antibodies) into the processing bodies.
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic\; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene.
eukaryotic translation initiation factor 4E transporter
, eukaryotic translation initiation factor 4E nuclear import factor 1
, eukaryotic translation initiation factor 4E transporter-like
, eIF4E transporter