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Eyes Absent Homolog 2 (Drosophila) Proteins (EYA2)

EYA2 encodes a member of the eyes absent (EYA) family of proteins. Additionally we are shipping EYA2 Antibodies (73) and EYA2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EYA2 14049 O08575
EYA2 2139 O00167
Rat EYA2 EYA2 156826  
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Top EYA2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$498.21
Details

EYA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
, ,

Top referenced EYA2 Proteins

  1. Human EYA2 Protein expressed in Escherichia coli (E. coli) - ABIN1098596 : Fan, Brass, Poncz, Spitz, Maire, Manning: The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN1098596

More Proteins for Eyes Absent Homolog 2 (Drosophila) (EYA2) Interaction Partners

Mouse (Murine) Eyes Absent Homolog 2 (Drosophila) (EYA2) interaction partners

  1. Eya2 in a physical complex with Six1 (show SIX1 Proteins) plays a critical role in physiological hypertrophy.

  2. Eya2 protein is required for hypaxial somitic myogenesis in the mouse embryo

  3. Eya2 prevents adverse cardiac remodeling under pressure overload partly through altering metabolic gene expression and preserving PI3K/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway.

Human Eyes Absent Homolog 2 (Drosophila) (EYA2) interaction partners

  1. SIX1 (show SIX1 Proteins) and EYA are often co-overexpressed in tumors, and the SIX1 (show SIX1 Proteins)-EYA2 interaction has been shown to be critical for metastasis in a breast cancer model.

  2. Decreased expression of EYA2 is associated with pancreatic adenocarcinomas.

  3. This interaction suggests that CDK6 (show CDK6 Proteins) regulates EYA2 activity, a mechanism that could be important in development and in cancer.

  4. MIR30A represses Eya2 expression by binding to the 3'-untranslated region of Eya2.The MIR30A/EYA2 axis regulates breast cancer cell proliferation and migration.

  5. Functional roles of candidate genes EYA2 (20q13) and hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-375 (2q35) were studied by siRNA-mediated knock-down and overexpression, respectively, in hrHPV-containing cell lines.

  6. Given that SIX1 (show SIX1 Proteins) and EYA are overexpressed in many tumor types, our data indicate that targeting the SIX1 (show SIX1 Proteins)-EYA complex may be a potent approach to inhibit tumor progression in multiple cancer types

  7. Studies indicate that the RNA and protein levels of Eya2 is upregulated in ovarian cancer.

  8. Data implicate Eya2 as a necessary co-factor for many of the metastasis promoting functions of Six1 (show SIX1 Proteins).

  9. Expression of EYA2 in lung adenocarcinoma is augmented.

  10. Based on observation that the dachshund-binding site is located between the catalytic core & Sine Oculis binding sites within ED-Eya2, we propose that catalytic activity can be translated to SO binding through DAC (show AADAC Proteins), which acts as a transcriptional switch.

EYA2 Protein Profile

Protein Summary

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined.

Gene names and symbols associated with EYA2

  • eyes absent homolog 2 (Drosophila) (EYA2)
  • eyes absent homolog 2 (Drosophila) (eya2)
  • eyes absent homolog 2 (eya2)
  • eyes absent homolog 2 (LOC100218165)
  • eyes absent 2 homolog (Drosophila) (Eya2)
  • eyes absent homolog 2 (Drosophila) (Eya2)
  • EAB1 protein
  • EYA2 protein
  • zgc:92279 protein

Protein level used designations for EYA2

eyes absent 2 , eyes absent homolog 2 , eyes absent homolog 2 (Drosophila) , Drosophila-type eyes absent 2-like protein , eyes absent 2 homolog

GENE ID SPECIES
395745 Gallus gallus
100071250 Equus caballus
458305 Pan troglodytes
447819 Danio rerio
100037919 Xenopus (Silurana) tropicalis
100218165 Taeniopygia guttata
14049 Mus musculus
2139 Homo sapiens
156826 Rattus norvegicus
615264 Bos taurus
609926 Canis lupus familiaris
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