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EYA2 encodes a member of the eyes absent (EYA) family of proteins. Additionally we are shipping EYA2 Antibodies (76) and EYA2 Kits (1) and many more products for this protein.
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Human EYA2 Protein expressed in Escherichia coli (E. coli) - ABIN1098596
Fan, Brass, Poncz, Spitz, Maire, Manning: The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins. in The Journal of biological chemistry 2000
Show all 2 references for ABIN1098596
Eya2 in a physical complex with Six1 (show SIX1 Proteins) plays a critical role in physiological hypertrophy.
Eya2 protein is required for hypaxial somitic myogenesis in the mouse embryo
Eya2 prevents adverse cardiac remodeling under pressure overload partly through altering metabolic gene expression and preserving PI3K/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway.
results demonstrate that overexpression of miR (show MLXIP Proteins)-30a in lung adenocarcinoma A549 cells can inhibit cell migration and invasion, which is partially attributed to the decrease of EYA2 expression
SIX1 (show SIX1 Proteins) and EYA are often co-overexpressed in tumors, and the SIX1 (show SIX1 Proteins)-EYA2 interaction has been shown to be critical for metastasis in a breast cancer model.
Decreased expression of EYA2 is associated with pancreatic adenocarcinomas.
This interaction suggests that CDK6 (show CDK6 Proteins) regulates EYA2 activity, a mechanism that could be important in development and in cancer.
MIR30A represses Eya2 expression by binding to the 3'-untranslated region of Eya2.The MIR30A/EYA2 axis regulates breast cancer cell proliferation and migration.
Functional roles of candidate genes EYA2 (20q13) and hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-375 (2q35) were studied by siRNA-mediated knock-down and overexpression, respectively, in hrHPV-containing cell lines.
Given that SIX1 (show SIX1 Proteins) and EYA are overexpressed in many tumor types, our data indicate that targeting the SIX1 (show SIX1 Proteins)-EYA complex may be a potent approach to inhibit tumor progression in multiple cancer types
Studies indicate that the RNA and protein levels of Eya2 is upregulated in ovarian cancer.
Data implicate Eya2 as a necessary co-factor for many of the metastasis promoting functions of Six1 (show SIX1 Proteins).
Expression of EYA2 in lung adenocarcinoma is augmented.
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined.
eyes absent 2
, eyes absent homolog 2
, eyes absent homolog 2 (Drosophila)
, Drosophila-type eyes absent 2-like protein
, eyes absent 2 homolog