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FBXO18 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXO18 Antibodies (35) and and many more products for this protein.
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FBH1 restraining RAD51 (show RAD51 ELISA Kits) DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination.
FBH1 helicase (show DNA2 ELISA Kits) activity is required to eliminate cells with excessive replication stress through the generation of MUS81 (show MUS81 ELISA Kits)-induced DNA double-strand breaks.
role of the F-box helicase (show DNA2 ELISA Kits) 1 (Fbh1) protein during genome maintenance in mammalian cells
FBH1 acts as a negative regulator of RAD51 (show RAD51 ELISA Kits) function in human cells
FBH1 inactivation appears to contribute to oncogenic transformation by allowing survival of cells undergoing replicative stress due to external factors such as UV irradiation.
The study reports a mechanism that controls the degradation of FBH1 after DNA damage.
FBH1 helicase activity is required to eliminate cells with excessive replication stress through the generation of MUS81 (show MUS81 ELISA Kits)-induced DNA double-strand breaks.
Ubiquitylation affects FBH1 interaction with the RAD51 (show RAD51 ELISA Kits) nucleoprotein filament, but not its translocase and helicase activities.
FBH1 helicase activity is required for the efficient induction of DSBs and apoptosis specifically in response to DNA replication stress.
hFBH1 exhibited DNA-dependent ATPase (show DNAH8 ELISA Kits) and DNA unwinding activities that displace duplex DNA in the 3' to 5' direction.
These findings suggest that the hFBH1 helicase is a functional human orthologue of budding yeast Srs2 that also possesses self-regulation properties necessary to execute its recombination functions.
Data show that the human Fbh1 (hFbh1) helicase accumulates at sites of DNA damage or replication stress in a manner dependent fully on its helicase activity and partially on its conserved F box.
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
F-box only protein 18
, F-box DNA helicase 1
, F-box only protein, helicase, 18