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FBXL19 encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. Additionally we are shipping FBXL19 Antibodies (22) and FBXL19 Proteins (3) and many more products for this protein.
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Collectively these data unveil that FBXL19 functions as an antagonist of Rac3 (show RAC3 ELISA Kits) by regulating its stability and regulates the TGFbeta1 (show TGFB1 ELISA Kits)-induced E-cadherin (show CDH1 ELISA Kits) down-regulation.
SCF (show KITLG ELISA Kits)(FBXL19) targets RhoA (show RHOA ELISA Kits) for its disposal, a process regulated by Erk2 (show MAPK1 ELISA Kits).
Data indicate that overexpression of FBXL19 decreased both Rac1 active and inactive forms and significantly reduced cellular migration.
The fundamental observation was that FBXL19 attenuated IL-33 (show IL33 ELISA Kits)-mediated activity by removing ST2L (show TMED1 ELISA Kits), but not sST2 (show SSTR2 ELISA Kits) or IL-1R1, on the cell surface.
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein binds to the transmembrane receptor ST2L and regulates its ubiquination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants.
F-box/LRR-repeat protein 19
, F-box and leucine-rich repeat protein 19
, f-box/LRR-repeat protein 19-like
, jumonji C domain-containing histone demethylase 1C