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FBXL19 encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. Additionally we are shipping FBXL19 Antibodies (22) and FBXL19 Kits (21) and many more products for this protein.
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Collectively these data unveil that FBXL19 functions as an antagonist of Rac3 (show RAC3 Proteins) by regulating its stability and regulates the TGFbeta1 (show TGFB1 Proteins)-induced E-cadherin (show CDH1 Proteins) down-regulation.
SCF (show KITLG Proteins)(FBXL19) targets RhoA (show RHOA Proteins) for its disposal, a process regulated by Erk2 (show MAPK1 Proteins).
Data indicate that overexpression of FBXL19 decreased both Rac1 active and inactive forms and significantly reduced cellular migration.
The fundamental observation was that FBXL19 attenuated IL-33 (show IL33 Proteins)-mediated activity by removing ST2L (show TMED1 Proteins), but not sST2 (show SSTR2 Proteins) or IL-1R1, on the cell surface.
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein binds to the transmembrane receptor ST2L and regulates its ubiquination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants.
F-box/LRR-repeat protein 19
, F-box and leucine-rich repeat protein 19
, f-box/LRR-repeat protein 19-like
, jumonji C domain-containing histone demethylase 1C