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F-Box and WD Repeat Domain Containing 4 Proteins (FBXW4)

FBXW4 is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. Additionally we are shipping FBXW4 Antibodies (73) and FBXW4 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FBXW4 6468 P57775
FBXW4 309444  
FBXW4 30838 Q9JMJ2
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Top FBXW4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

FBXW4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)
Mouse (Murine)

More Proteins for F-Box and WD Repeat Domain Containing 4 (FBXW4) Interaction Partners

Human F-Box and WD Repeat Domain Containing 4 (FBXW4) interaction partners

  1. biochemical characterization of the novel F-box and WD40 (show DCAF12L2 Proteins) containing protein, FBXW4

  2. a complex rearrangement associated with a approximately 0.5 Mb tandem duplication ion containing a disrupted extra copy of the DACTYLIN gene and the entire LBX1 (show Lbx1 Proteins) and beta-TRCP (show BTRC Proteins) genes.

  3. results indicate that genomic rearrangement of SHFM3 is rare among non-syndromic SHFM patients and emphasize the importance of screening for genomic rearrangements even in sporadic cases of SHFM

  4. Genomic rearrangements involving the SHFM3 locus at chromosome 10q24 is associated with syndromic and non-syndromic split-hand/foot malformation

Mouse (Murine) F-Box and WD Repeat Domain Containing 4 (FBXW4) interaction partners

  1. Both dactylaplasia-related Dac (show DACH1 Proteins) insertions are caused by a type D mouse endogenous provirus (MusD) element, which can be silenced by Mda.

  2. Dactylaplasia in mouse is not associated with duplication of Fbxw4, in contrast with the described human cases.

FBXW4 Protein Profile

Protein Summary

This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds\; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.

Gene names and symbols associated with FBXW4

  • F-box and WD-40 domain protein 4 (fbxw4)
  • F-box and WD repeat domain containing 4 (FBXW4)
  • F-box and WD repeat domain containing 4 (Fbxw4)
  • F-box and WD-40 domain protein 4 (Fbxw4)
  • Dac protein
  • dactylin protein
  • dactylyn protein
  • Fbw4 protein
  • FBWD4 protein
  • FBXW4 protein
  • hag protein
  • hagoromo protein
  • SHFM3 protein
  • SHSF3 protein
  • wu:fk63g06 protein

Protein level used designations for FBXW4

F-box/WD repeat-containing protein 4 , dactylaplasia , fk63g06 , F-box and WD repeat domain containing 4 , F-box and WD-40 domain protein 4 , F-box and WD-40 domain-containing protein 4 , F-box/WD repeat protein 4 , dactylin , F-box protein Fbw4 , protein hagoromo

GENE ID SPECIES
58035 Danio rerio
450689 Pan troglodytes
6468 Homo sapiens
309444 Rattus norvegicus
100721914 Cavia porcellus
101113450 Ovis aries
30838 Mus musculus
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