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FOXRED1 encodes a protein that contains a FAD-dependent oxidoreductase domain. Additionally we are shipping FAD-Dependent Oxidoreductase Domain Containing 1 Proteins (3) and many more products for this protein.
Showing 10 out of 40 products:
Human Polyclonal FOXRED1 Primary Antibody for WB - ABIN527572
Fassone, Duncan, Taanman, Pagnamenta, Sadowski, Holand, Qasim, Rutland, Calvo, Mootha, Bitner-Glindzicz, Rahman: FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy. in Human molecular genetics 2010
Cow (Bovine) Polyclonal FOXRED1 Primary Antibody for WB - ABIN2779113
Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: The LIFEdb database in 2006. in Nucleic acids research 2005
Results show that depletion of FOXRED1 in myoblasts results in decreased levels of fully assembled complexes I and II. FOXRED1 associates with the ND1 (show MT-ND1 Antibodies)-containing subcomplexes of ~370 kDa and ~620 kDa and that FOXRED1 activity is required for the formation of a 550-kDa subcomplex of complex I.
Loss of FOXRED1, coupled with protein, choline and/or folate-deficient diets results in the depletion of glutathione, the dysregulation of nitric oxide metabolism and the peroxynitrite-mediated inactivation of complex I.
A structural model of FOXRED1 reveals a large substrate-binding cavity and a putative oxygen-binding site.
FOXRED1 is a crucial component in the productive assembly of respiratory chain complex I and that mutations in FOXRED1 leading to partial loss of function cause defects in complex I biogenesis.
Mutations in FOXRED1 are associated with complex I deficiency.
This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene.
FAD-dependent oxidoreductase domain-containing protein 1
, testis expressed gene 23