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Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. Additionally we are shipping FBXL12 Antibodies (41) and FBXL12 Kits (12) and many more products for this protein.
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Study found that Fbl12 binds and ubiquitinates p21 (show CDKN1A Proteins) which allows its stability. In addition, Fbl12 regulates default degradation under basal conditions but not under UV-stimulated conditions. These findings elucidate novel mechanisms that underlie the regulation of p21 (show CDKN1A Proteins) expression level in cells.
FBXL12 plays a key role in the down-regulation of ALDH3 (show ALDH3A1 Proteins) activity in trophoblast stem cells and thus initiates trophoblast differentiation during placental development.
Fbxl12-induced CaMKI (show CAMK1 Proteins) degradation attenuates p27 (show PAK2 Proteins) phosphorylation at these sites in early G1 and iii) activation of CaMKI (show CAMK1 Proteins) during G1 transition followed by p27 (show PAK2 Proteins) phosphorylation appears to be upstream to other p27 (show PAK2 Proteins) phosphorylation events
Study investigated the role of FBXL12 in T-cell development by examination of FBXL12-null mice, finding that the FBXL12-ALDH3 (show ALDH3A1 Proteins) axis plays a key role in regulation of the positive selection of T cells.
Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004
, F-box and leucine-rich repeat protein 12
, F-box/LRR-repeat protein 12-like
, f-box/LRR-repeat protein 12-like
, F-box protein FBL12
, F-box/LRR-repeat protein 12
, F-box protein containing leucine repeats 12