You are viewing an incomplete version of our website. Please click to reload the website as full version.

FIP1 Like 1 (S. Cerevisiae) Proteins (FIP1L1)

FIP1L1 encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. Additionally we are shipping FIP1 Like 1 (S. Cerevisiae) Antibodies (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FIP1L1 81608 Q6UN15
Rat FIP1L1 FIP1L1 289582 Q5U317
FIP1L1 66899 Q9D824
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top FIP1 Like 1 (S. Cerevisiae) Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

FIP1L1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for FIP1 Like 1 (S. Cerevisiae) (FIP1L1) Interaction Partners

Human FIP1 Like 1 (S. Cerevisiae) (FIP1L1) interaction partners

  1. F604S exchange in FIP1L1-PDGFRA (show PDGFRA Proteins) enhances FIP1L1-PDGFRA (show PDGFRA Proteins) protein stability via SHP-2 (show PTPN11 Proteins) and SRC (show SRC Proteins) and is associated with kinase inhibitor resistance in hypereosinophilic syndrome and chronic eosinophilic leukemia.

  2. FIP1L1 differentially contributes to the pathogenesis of distinct types of leukemia.

  3. FP fusion gene favors secondary KIT mutations in MCs (show SMCP Proteins) via growth and proliferation signals or that a yet unknown mechanism causes genomic instability with independent evolution of FP and KIT D816V

  4. Oncostatin M (show OSM Proteins) is a FIP1L1/PDGFRA (show PDGFRA Proteins)-dependent mediator of cytokine production in chronic eosinophilic leukemia.

  5. description of polycythemia vera (show IGF2BP3 Proteins) concurrent with FIP1L1-PDGFRA (show PDGFRA Proteins)-positive myeloproliferative neoplasm with eosinophilia [case report]

  6. Data show that the cyclin-dependent kinase 7/9 inhibitor (CDK7/9 inhibitor) potently inhibits FIP1L1-PDGFRalpha-positive Bcr-Abl-positive chronic myeloid leukemia (CML) cells.

  7. results strongly suggest that JAK2 (show JAK2 Proteins) is activated by Fip1 (show RRAGA Proteins)-like1 (FIP1L1)-platelet-derived growth factor receptor alpha (show PDGFRA Proteins) (F/P) and is required for F/P stimulation of cellular proliferation and infiltration in chronic eosinophilic leukemia

  8. Treatment with imatinib is associated with an excellent prognosis in FIP1L1-PDGFRA (show PDGFRA Proteins)-positive chronic eosinophilic leukemia in first chronic phase

  9. FIP1L1/PDGFRA (show PDGFRA Proteins) fusion gene-positive myeloproliferative disorders with eosinophilia are discussed.

  10. The hypereosinophilic syndrome may result from a novel fusion tyrosine kinase (show TXK Proteins) - FIP1L1-PDGFRalpha - that is a consequence of an interstitial chromosomal deletion.

Mouse (Murine) FIP1 Like 1 (S. Cerevisiae) (FIP1L1) interaction partners

  1. FIP1L1-PDGFRalpha activation requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent

FIP1 Like 1 (S. Cerevisiae) (FIP1L1) Protein Profile

Protein Summary

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with FIP1L1

  • factor interacting with PAPOLA and CPSF1 (fip1l1)
  • FIP1 like 1 (S. cerevisiae) (FIP1L1)
  • factor interacting with PAPOLA and CPSF1 (FIP1L1)
  • factor interacting with PAPOLA and CPSF1 (Fip1l1)
  • FIP1 like 1 (S. cerevisiae) (Fip1l1)
  • FIP1 like 1b (S. cerevisiae) (fip1l1b)
  • 1300019H17Rik protein
  • FIP1 protein
  • fip1l1 protein
  • hFip1 protein
  • Rhe protein
  • Rje protein
  • wu:fd36f11 protein
  • zgc:103421 protein

Protein level used designations for FIP1L1

FIP1 like 1 , FIP1-like 1 protein , pre-mRNA 3'-end-processing factor FIP1 , FIP1L1 cleavage and polyadenylation specific factor subunit , factor interacting with PAP , rearranged in hypereosinophilia

GENE ID SPECIES
733481 Xenopus (Silurana) tropicalis
100172699 Pongo abelii
81608 Homo sapiens
494780 Xenopus laevis
289582 Rattus norvegicus
422754 Gallus gallus
612980 Canis lupus familiaris
100138550 Bos taurus
66899 Mus musculus
450021 Danio rerio
Selected quality suppliers for FIP1 Like 1 (S. Cerevisiae) Proteins (FIP1L1)
Did you look for something else?