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FK506 Binding Protein 1A, 12kDa Proteins (FKBP1A)

The protein encoded by FKBP1A is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FK506 Binding Protein 1A, 12kDa Antibodies (87) and FK506 Binding Protein 1A, 12kDa Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FKBP1A 14225 P26883
Rat FKBP1A FKBP1A 25639 Q62658
FKBP1A 2280 P62942
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Top FK506 Binding Protein 1A, 12kDa Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$357.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$206.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 16 Days
$206.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human GST tag FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 2-103), (partial) protein (GST tag) 1 mg Log in to see 56 to 66 Days
$1,842.50
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,196.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,196.33
Details

FKBP1A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

Top referenced FK506 Binding Protein 1A, 12kDa Proteins

  1. Mouse (Murine) FKBP1A Protein expressed in Escherichia coli (E. coli) - ABIN2007586 : Siekierka, Hung, Poe, Lin, Sigal: A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. in Nature 1989 (PubMed)
    Show all 4 references for ABIN2007586

  2. Human FKBP1A Protein expressed in Escherichia coli (E. coli) - ABIN2002473 : Liu, Farmer, Lane, Friedman, Weissman, Schreiber: Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. in Cell 1991 (PubMed)
    Show all 4 references for ABIN2002473

  3. Human FKBP1A Protein expressed in Wheat germ - ABIN1354116 : Åström-Olsson, Li, Olofsson, Borén, Öhlin, Grip: Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium dynamics. in Biochemical and biophysical research communications 2012 (PubMed)
    Show all 3 references for ABIN1354116

  4. Human FKBP1A Protein expressed in Escherichia coli (E. coli) - ABIN666754 : Jayaraman, Brillantes, Timerman, Fleischer, Erdjument-Bromage, Tempst, Marks: FK506 binding protein associated with the calcium release channel (ryanodine receptor). in The Journal of biological chemistry 1992 (PubMed)
    Show all 2 references for ABIN666754

More Proteins for FK506 Binding Protein 1A, 12kDa (FKBP1A) Interaction Partners

Silk Worm FK506 Binding Protein 1A, 12kDa (FKBP1A) interaction partners

  1. expression higher in the silk gland and gut (show GUSB Proteins)

  2. A cDNA encoding the 12 kDa FKBP gene orthologue (FKBP12) in Bombyx mori was been isolated from both Bm-5 cultured cells and silk-gland tissue.

Mouse (Murine) FK506 Binding Protein 1A, 12kDa (FKBP1A) interaction partners

  1. We demonstrate that FKBP12 and its ligands impact multiple aspects of muscle function.

  2. Fkbp1a-mediated regulation of Notch1 (show NOTCH1 Proteins) plays an important role in intercellular communication between endocardium and myocardium.

  3. FKBP12 is critically important in regulating trans-sarcolemmal ionic currents, predominately the voltage-gated Na+ current, I Na

  4. the impact of simulated ischemia and reperfusion on expression of the calcium handling proteins FKBP12 and FKBP12.6 (show FKBP1B Proteins), and intracellular calcium dynamics was investigated.

  5. Data show that deletion of FKBP12 increased transforming growth factor-beta receptor activation and SMAD2 (show SMAD2 Proteins)/3 signaling.

  6. FKBP12 is a critical regulator of I(Na) and is important for cardiac arrhythmogenic physiology

  7. a trimeric-interaction among calcineurin (show PPP3CA Proteins), FKBP12, and RyR is important for the regulation of the RyR channel activity and may play an important role in the Ca(2 (show CA2 Proteins)+) signaling of muscle contraction and relaxation

  8. FKBP12 binding to RyR1 enhances the gain of skeletal muscle excitation-contraction coupling

  9. used systemic gene transfer in tumor-bearing mice to identify novel antiinvasive and antimetastatic functions for Fkbp8 (show FKBP8 Proteins), and subsequently for Fkbp1a

  10. FKBP12 deficiency alters both orthograde and retrograde coupling between the L-type Ca2+ channel and RyR1 and the consequences of these changes depend on muscle type and activity

Human FK506 Binding Protein 1A, 12kDa (FKBP1A) interaction partners

  1. Findings indicate that mutant huntingtin (show HTT Proteins) (mHTT) aggregates can be transformed into benign species by isomerase FKBP12.

  2. RyRs have been identified as important targets of FKBP12 and FKBP12.6 (show FKBP1B Proteins), members of the immunophilin family

  3. How phosphorylation of RyR affects channel activity and whether proteins such as the FK-506 binding proteins (FKBP12 and FKBP12.6 (show FKBP1B Proteins)) are involved in heart failure

  4. Ultra-fast Shape Recognition with Atom Types--the discovery of novel bioactive small molecular scaffolds for FKBP12 and 11betaHSD1.

  5. Selectivity within the FKBP (show FKBP7 Proteins) family, in particular selective inhibition of FKBP12 or FKBP51 (show FKBP4 Proteins), is possible. FKBP51 (show FKBP4 Proteins) is a pharmacologically tractable target for stress-related disorders.

  6. peptidyl prolyl cis-trans isomerase (show PPIL1 Proteins) activity of FKBP12 probably plays a role in inhibition of receptor phosphorylation.

  7. FKBP12 inhibits RyR1 and FKBP12 E31Q/D32N/W59F mutant activates RyR1 in vitro.

  8. FKBP12 regulates the localization and processing of amyloid precursor protein (show APP Proteins) in human cell lines.

  9. Enhanced plasticity in the active site of FKBP12.6 (show FKBP1B Proteins) is likely to contribute to marked attenuation in the spatial extent of the residues that exhibit doubling of their amide resonances compared with those of the homologous FKBP12.

  10. the structural basis of the slow resonance doubling transition of FKBP12 and the more rapid conformational linebroadening transition in the 80's loop to gain insight into how these effects are propagated through the protein structure

Rabbit FK506 Binding Protein 1A, 12kDa (FKBP1A) interaction partners

  1. Data indicate that S107 increased FKBP12 binding to RyR1 in sarcoplasmic reticulum vesicles in the presence of reduced glutathione and the NO-donor NOC12.

  2. A mutant with substitution at the sole cysteine residue of FKBP-12 (C23S) did not form dimers or trimers.

  3. phosphorylation and K201 acted similarly to change the conformation of RyR1/2 and regulate FKBP12/12.6 binding.

Xenopus laevis FK506 Binding Protein 1A, 12kDa (FKBP1A) interaction partners

  1. Stoichiometry of binding sites and FKBP (show FKBP7 Proteins) exchange binding.

FK506 Binding Protein 1A, 12kDa (FKBP1A) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.

Gene names and symbols associated with FKBP1A

  • FK506-binding protein (Fkbp12)
  • peptidyl-prolyl isomerase FKBP12 (FKBP12)
  • FK506 binding protein 1Aa (fkbp1aa)
  • FK506 binding protein 1A, 12kDa (FKBP1A)
  • FK506-binding protein (LOC733041)
  • FK506-binding protein (EHI_180160)
  • fk506-binding protein (AaeL_AAEL010491)
  • FK506-binding protein (Fkbp13)
  • FK506 binding protein like (FKBPL)
  • FK506 binding protein 1a (Fkbp1a)
  • Peptidyl-prolyl cis-trans isomerase FKBP1A-like (fkbp1a)
  • 12kDa protein
  • ARABIDOPSIS THALIANA FK506-BINDING PROTEIN 12 protein
  • ATFKBP12 protein
  • Bmfkbp13 protein
  • fj02g10 protein
  • FK506-binding protein 12 protein
  • Fkbp protein
  • FKBP-1A protein
  • FKBP-12 protein
  • FKBP1 protein
  • FKBP1A protein
  • FKBP1B protein
  • Fkbp2 protein
  • FKBP12 protein
  • FKBP12-T1 protein
  • FKBP12-T2 protein
  • IMMUNOPHILIN protein
  • mFKBP1 protein
  • mFKBP12 protein
  • MSJ1.19 protein
  • MSJ1_19 protein
  • PKC12 protein
  • PKCI2 protein
  • PPIASE protein
  • Rotamase protein
  • wu:fj02g10 protein
  • zgc:73373 protein

Protein level used designations for FKBP1A

FK506-binding protein , FK506 binding protein 1A, 12kDa , peptidyl-prolyl cis-trans isomerase FKBP1A , fk506-binding protein , FK506-binding protein-like , 12 kDa FK506-binding protein , 12 kDa FKBP , FK506 Binding Protein12-T1 , FK506 binding protein12 , FK506 binding protein12-T2 , FK506-binding protein 1A , FKBP-12 , FKBP-1A , FKBP12-Exip3 , PPIase FKBP1A , calstabin-1 , immunophilin FKBP12 , rotamase , FK506 binding protein 2 (13 kDa) , FK506-binding protein 1 (12kD) , FK506-binding protein 1a , FK506-binding protein 1 , FK506-binding protein 12 , FK506-binding protein 1A (12kD) , FK506-binding protein, T-cell, 12-kD , calstabin 1 , protein kinase C inhibitor 2 , FK506 binding protein 1B, 12.6 kDa , Immunophilin FKBP12 , binding protein , FK 506-binding protein

GENE ID SPECIES
732917 Bombyx mori
836556 Arabidopsis thaliana
335335 Danio rerio
374233 Gallus gallus
539546 Bos taurus
608169 Canis lupus familiaris
733041 Bombyx mori
749347 Pan troglodytes
3408135 Entamoeba histolytica HM-1:IMSS
5573443 Aedes aegypti
100141467 Bombyx mori
100154784 Sus scrofa
14225 Mus musculus
25639 Rattus norvegicus
2280 Homo sapiens
614795 Bos taurus
100328942 Oryctolagus cuniculus
379069 Xenopus laevis
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