FKBP1A Protein (partial) (His tag)

Catalog No. ABIN5608464

Product Details

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Protein Type: Recombinant

Protein Characteristics: partial

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This FKBP1A protein is labelled with His tag.

Application: Western Blotting (WB)

Sequence: Met 1 - Glu 108

Purity: >95 % as determined by SDS-PAGE.

Endotoxin Level: Endotoxin level is less than 1.0 EU per ug by the LAL method.

Application Details

Application Notes: This recombinant protein can be used for WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 50 mM HEPES, 150 mM NaCl, pH 7.5

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C,-80 °C

Storage Comment: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.

Target Details

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Alternative Name: FKBP12 (FKBP1A Products)

Synonyms: 12kDa Protein, FKBP12 Protein, FKBP12-T1 Protein, FKBP12-T2 Protein, Fkbp Protein, Fkbp1 Protein, mFKBP1 Protein, mFKBP12 Protein, FKBP-12 Protein, FKBP-1A Protein, FKBP1 Protein, Rotamase Protein, Fkbp12 Protein, ARABIDOPSIS THALIANA FK506-BINDING PROTEIN 12 Protein, ATFKBP12 Protein, FK506-binding protein 12 Protein, IMMUNOPHILIN Protein, MSJ1.19 Protein, MSJ1_19 Protein, PKC12 Protein, PKCI2 Protein, PPIASE Protein, FKBP1B Protein, Fkbp2 Protein, fj02g10 Protein, zgc:73373 Protein, wu:fj02g10 Protein, FKBP1A Protein, Bmfkbp13 Protein, zgc:103752 Protein, FK506 binding protein 1a Protein, FK506 binding protein 1A Protein, FK506-binding protein Protein, FK506-binding protein 12 Protein, FK506 binding protein 1Aa Protein, FK506 binding protein 1C Protein, FK506-binding protein 59 Protein, FK506 binding protein like Protein, FK506 binding protein 1A L homeolog Protein, FK506 binding protein 1Ab Protein, Fkbp1a Protein, FKBP1A Protein, Fkbp12 Protein, FKBP12 Protein, fkbp1aa Protein, FKBP1C Protein, EHI_180160 Protein, LOC5573443 Protein, Fkbp13 Protein, FKBPL Protein, fkbp1a.L Protein, fkbp1ab Protein

Background: Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.

Molecular Weight: 12.8 kDa

Gene ID: 2280

UniProt: P62942

Pathways: Negative Regulation of Transporter Activity, Methionine Biosynthetic Process