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The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FKBP5 Proteins (13) and FKBP5 Kits (6) and many more products for this protein.
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Dog (Canine) Monoclonal FKBP5 Primary Antibody for ICC, IF - ABIN361795
Cheung-Flynn, Roberts, Riggs, Smith: C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90. in The Journal of biological chemistry 2003
Show all 6 references for ABIN361795
Human Polyclonal FKBP5 Primary Antibody for IF, IHC (p) - ABIN515669
Romano, Staibano, Greco, Brunetti, Nappo, Ilardi, Martinelli, Sorrentino, Di Pace, Mascolo, Bisogni, Scalvenzi, Alfano, Romano: FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential. in Cell death & disease 2013
Show all 3 references for ABIN515669
Chicken Polyclonal FKBP5 Primary Antibody for IHC, WB - ABIN2785846
Lekman, Laje, Charney, Rush, Wilson, Sorant, Lipsky, Wisniewski, Manji, McMahon, Paddock: The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort. in Biological psychiatry 2008
Human Monoclonal FKBP5 Primary Antibody for ELISA, WB - ABIN560908
van Lierop, Alkema, Laskewitz, Dijkema, van der Maaden, Smit, Plate, Conti, Jans, Timmers, van Boeckel, Lusher, McGuire, van Schaik, de Vlieg, Smeets, Hofstra, Boots, van Duin, Ingelse, Schoonen et al.: Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index. ... in PLoS ONE 2012
FKBP51 (show FKBP4 Antibodies) appears to be a common denominator to epithelial to mesenchymal transition, cancer stemness and drug resistance, in melanoma. [review]
Clinical evidence for the role of the glucocorticoid receptor (show NR3C1 Antibodies)-GRFKBP51 system in mental disorders is presented here. [review]
Interaction effect between childhood abuse and the FKBP5 gene rs1360780 SNP on positive psychotic experiences.
3 FKBP5 SNPs (rs3800373, rs7753746, and rs9380526) predicted chronic postconcussive symptom severity. Similar effect sizes were observed for the minor alleles of rs7753746 and rs9380526.
This review illustrates how FKBP5 genetic variants confer risk for stress-related disorders.
Results show that allelic variants in the rs1360780 region of the FKBP5 gene are associated with differences in regional brain activity during evaluation of emotional stimuli in patients with Major Depressive Disorder
Results indicate that genetic variation in FKBP5 influences the risk of anxiety and/or depressive disorders in preschool age by altering the sensitivity to the deleterious effects of mild to moderate adverse events
Study indicates that genetic alterations in FKBP5 may influence vulnerability to suicide
These findings point to the minor alleles of the FKBP5 polymorphism being a risk factor for development of intrusive memories, possibly as a result of impaired glucocorticoid receptor (show NR3C1 Antibodies) sensitivity.
the abundance of BDNF (show BDNF Antibodies) positively correlated and phosphorylated DNMT1 (show DNMT1 Antibodies) inversely correlated with that of FKBP51 (show FKBP4 Antibodies) in cells
We discovered that the suggested psychiatric risk factor FK506 binding protein (show FKBPL Antibodies) 51 (FKBP51) increases phosphorylation of GSK3beta (show GSK3b Antibodies) at serine 9 (pGSK3beta(S9)).
Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation (show HELLS Antibodies), and its subsequent regulation of glucocorticoid receptor (show NR3C1 Antibodies) sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton
the abundance of BDNF (show BDNF Antibodies) positively correlated and phosphorylated DNMT1 (show DNMT1 Antibodies) inversely correlated with that of FKBP51 in cells
FKBP5 associates with BECN1 (show BECN1 Antibodies), changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux
Aged animals display elevated FKBP51 levels, which contribute to impaired resiliency to depressive-like behaviors through impaired glucocorticoid signaling, a phenotype that is abrogated in FKBP5-/- mice.
Overexpression of FKBP51 in the amygdala resulted in increased anxiety-related behavior.
the stress response, as well as the effects of antidepressants on behavior and autophagic markers, depends on FKBP51.
FKBP51 is a key regulator of adipogenesis via the Akt (show AKT1 Antibodies)-p38 (show CRK Antibodies) pathway.
FKBP51 loss reciprocally regulates glucocorticoid receptor alpha (show NR3C1 Antibodies) and PPARgamma (show PPARG Antibodies) via 2 complementary mechanisms.
In mice, the absence of the Fkbp5 gene enhances sensitivity to alcohol withdrawal.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
FK506 binding protein 5
, FK506-binding protein 5
, PPIase FKBP5
, peptidyl-prolyl cis-trans isomerase FKBP5
, 51 kDa FK506-binding protein 5
, 51 kDa FKBP
, 54 kDa progesterone receptor-associated immunophilin
, FF1 antigen
, HSP90-binding immunophilin
, T-cell FK506-binding protein
, androgen-regulated protein 6
, peptidylprolyl cis-trans isomerase
, 51 kDa FK506-binding protein