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The Fos gene family consists of 4 members FOSL1, and FOSL2. Additionally we are shipping FOSL1 Antibodies (84) and FOSL1 Kits (17) and many more products for this protein.
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Our results demonstrate that Fra-1 is an important determinant of the metastatic potential of human colon cancer cells, and that the Fra-1 classifier can be used as a prognostic predictor in colon cancer patients.
Results suggest that Fra-1 is upregulated in lung cancer tissues and functions by affecting the P53 (show TP53 Proteins) signaling pathway.
SIRT1 (show SIRT1 Proteins) expression correlated positively with Fra-1 expression, metastasis and overall survival in patients with colorectal cancer
We identified and confirmed that Fra-1 affected the expression level of CTTN (show CTTN Proteins) and EZR (show EZR Proteins) in vitro through LC-MS/MS analyses and western blot technology.
miR (show MLXIP Proteins)-195 can repress the migration and invasion of prostate cancer cells via regulating Fra-1
Results suggested that Fra-1 expression is low in cervical cancer tissues and promotes apoptosis of cervical cancer cells by p53 (show TP53 Proteins) signaling pathway.
High Fra-1 expression significantly correlates with shorter overall survival.
Fra-1 induces critical changes in the expression of tgfb1 and Epithelial-to-mesenchymal transition transcription factors through direct binding to the tgfb1, zeb1 and zeb2 genomic regulatory regions.
Fra1 promotes the growth of HaCaT cells in vitro by arresting the cell cycle and inhibiting cell apoptosis.
Intense immunohistochemical staining of Fra-1 was observed at the tumor marginal area adjacent to inflammatory cells and in parallel with IL-6 (show IL6 Proteins) secretion and STAT3 (show STAT3 Proteins) activation in colorectal cancer tissues.
Adipose-derived stromal cells overexpressing Fra-1 effectively protect against osteoarthritis.
Overexpression of Fosl1, which encodes a component of the AP-1 (show JUN Proteins) transcription factor complex, in osteoblasts significantly blocked malleal capillary narrowing.
Fra-1 gene expression is activated in response lipopolysaccharide induced lung-injury in mice.
Data suggest that expression of Fra1 (fos-related antigen 1) in preadipocytes is up-regulated by arachidonic acid (AA) during late stages of adipogenesis; however, in early stage of adipogenesis, AA inhibits adipogenesis via Fra1-dependent mechanism.
Fra-1 plays a key role in promoting chronic CS-induced lung macrophagic inflammation in vivo
we demonstrate that Fra1 negatively controls plasma cell differentiation by repressing Blimp1 (show PRDM1 Proteins) expression.
observations suggest that MyoD (show MYOD1 Proteins) and pRb (show PGR Proteins) work together cooperatively at the level of the intronic enhancer of Fra-1 during terminal cell cycle arrest
findings, based on a definitive genetic mouse model provide fundamental insights into mammary duct maturation and homeostasis and reveal that Scrib loss activates a MAPK (show MAPK1 Proteins)/Fra1 pathway that alters mammary progenitor activity
findings support the hypothesis that miR (show MLXIP Proteins)-19a-3p, which regulates tumor-associated macrophages(TAMs)in the breast tumor microenvironment,is able to regulate the phenotype of TAMs by targeting the Fra-1 gene and other genes in its downstream signaling pathway
these results indicate that Fra-1 is a direct target of Runx2 (show RUNX2 Proteins) during osteogenic differentiation of C2C12 myogenic progenitor cells.
The Fos gene family consists of 4 members FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
, fos-related antigen 1
, FOS-like antigen 1