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Family with Sequence Similarity 3, Member B Proteins (FAM3B)

Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Additionally we are shipping Family with Sequence Similarity 3, Member B Antibodies (64) and Family with Sequence Similarity 3, Member B Kits (52) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FAM3B 54097 P58499
FAM3B 52793 Q9D309
Rat FAM3B FAM3B 304050  
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Top Family with Sequence Similarity 3, Member B Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Fc Tag 100 μg Log in to see 2 to 3 Days
$346.50
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Cells Human Fc Tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_HEK-293 Human Fc Tag   0.1 mg Log in to see 2 to 3 Days
$618.75
Details
HOST_Escherichia coli (E. coli) Varicella Zoster Virus Un-conjugated   100 μg Log in to see 6 to 11 Days
$385.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   2 μg Log in to see 6 Days
$168.54
Details

FAM3B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,
Mouse (Murine)

Top referenced Family with Sequence Similarity 3, Member B Proteins

  1. Human FAM3B Protein expressed in HEK-293 Cells - ABIN2181066 : Yang, Gao, Robert, Burkhardt, Gaweska, Wagner, Wu, Greene, Young, Wolf: Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells. in Biochemistry 2005 (PubMed)
    Show all 4 references for ABIN2181066

More Proteins for Family with Sequence Similarity 3, Member B (FAM3B) Interaction Partners

Human Family with Sequence Similarity 3, Member B (FAM3B) interaction partners

  1. in-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP (show MLXIPL Proteins).

  2. beta-cell-secreted PANDER regulated the hepatic insulin (show INS Proteins) and lipogenenic signaling and impact overall glycemia.

  3. our studies demonstrated that silencing FAM3B promoted p53 (show TP53 Proteins) phosphorylation and induced p53 (show TP53 Proteins) accumulation by decreasing Mdm2 (show MDM2 Proteins) expression, which resulted in apoptotic cell death.

  4. These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug (show SNAI2 Proteins).

  5. Helices B and C and the second disulfide bond of PANDER are essential for PANDER-induced beta-cell death.

  6. PANDER is secreted from 2 types of pancreatic cells, glucose stimulates its secretion in beta cell and primary islets but not in alpha-cells, it is likely cosecreted with insulin (show INS Proteins), and structure and conformation is vital for PANDER secretion.

Mouse (Murine) Family with Sequence Similarity 3, Member B (FAM3B) interaction partners

  1. in-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP (show MLXIPL Proteins).

  2. F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 (show DGAT1 Proteins) expression

  3. X-ray crystal structure of the mouse FAM3B protein.

  4. these results demonstrated that the JNK (show MAPK8 Proteins)-mediated signaling mechanism of palmitic acid -induced beta-cell apoptosis involves up-regulated expression of PANDER and activation of caspase-3 (show CASP3 Proteins).

  5. Data suggest a new link between the endocrine and immune systems and provide useful information for further investigating the physiological functions of PANDER and its involvement in inflammation-related pancreatic disorders.

  6. Palmitic acid induces the expression of PANDER and the apoptosis of beta-TC3 cells while glucagon-like peptide-1 (show GCG Proteins) counteracts the above effects through an activation of Akt (show AKT1 Proteins) signaling.

  7. PANDER promotes lipogenesis and compromises insulin (show INS Proteins) signaling in the liver by increasing FOXO1 (show FOXO1 Proteins) activity.

  8. Findings further indicate PANDER impacts glycemic levels and may represent a potential but complicated therapeutic target.

  9. A paracrine/endocrine effect of insulin (show INS Proteins) on Pander release and a potential glucose-regulatory role for Pander.

  10. we provide evidence that identifies PANDER as a regulator of hepatic glucose metabolism, where it amplifies hepatic cAMP and cAMP-response element-binding protein signaling to induce gluconeogenic gene expression and glucose output.

Family with Sequence Similarity 3, Member B (FAM3B) Protein Profile

Protein Summary

Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Present in insulin secretory granules and likely cosecreted with insulin.

Gene names and symbols associated with FAM3B

  • family with sequence similarity 3, member B (LOC100221253)
  • family with sequence similarity 3, member B (FAM3B)
  • family with sequence similarity 3, member B (Fam3b)
  • 2-21 protein
  • 9030624C24Rik protein
  • C21orf11 protein
  • C21orf76 protein
  • D16Jhu19e protein
  • ORF9 protein
  • Pander protein
  • RGD1311662 protein

Protein level used designations for FAM3B

family with sequence similarity 3, member B , D21M16SJHU19e , cytokine-like protein 2-21 , pancreatic derived factor , pancreatic-derived factor , protein FAM3B

GENE ID SPECIES
100221253 Taeniopygia guttata
54097 Homo sapiens
52793 Mus musculus
514701 Bos taurus
478419 Canis lupus familiaris
418527 Gallus gallus
100517916 Sus scrofa
304050 Rattus norvegicus
101119956 Ovis aries
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