FAM3B Protein (Fc Tag)
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- Target See all FAM3B Proteins
- FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This FAM3B protein is labelled with Fc Tag.
- Purpose
- Recombinant Human FAM3B (C-Fc)
- Sequence
- Glu30-Ser235
- Characteristics
- Recombinant Human Protein FAM3B is produced by our Mammalian expression system and the target gene encoding Glu30-Ser235 is expressed with a Fc tag at the C-terminus.
- Purity
- >95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Family with Sequence Similarity 3, Member B (FAM3B) (AA 30-235) protein (His tag)
FAM3B Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Family with Sequence Similarity 3, Member B (FAM3B) (AA 1-235) protein (GST tag)FAM3B Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Family with Sequence Similarity 3, Member B (FAM3B) (AA 30-235) protein (His tag)Crystallography grade FAM3B Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Family with Sequence Similarity 3, Member B (FAM3B) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)FAM3B Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))
- Alternative Name
- FAM3B (FAM3B Products)
- Synonyms
- 2-21 Protein, C21orf11 Protein, C21orf76 Protein, ORF9 Protein, PANDER Protein, 9030624C24Rik Protein, D16Jhu19e Protein, Pander Protein, RGD1311662 Protein, family with sequence similarity 3 member B Protein, family with sequence similarity 3, member B Protein, FAM3B Protein, Fam3b Protein
- Target Type
- Viral Protein
- Background
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Background: FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.
Synonym: Sialic acid-binding Ig-like lectin 9,Siglec-9,CDw329,Protein FOAP-9,SIGLEC9
- Molecular Weight
- 50 kDa
- UniProt
- P58499
- Pathways
- Hormone Transport
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