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Involved in cellular calcium homeostasis regulation (By similarity). Additionally we are shipping Family with Sequence Similarity 82, Member A2 Antibodies (39) and many more products for this protein.
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High PTPIP51 expression is associated with glioblastoma.
PTPIP51 is regulated by its phosphorylation status combined with a thereby induced subcellular redistribution.
The presented data confirms a tyrosine phosphorylation-dependent interaction of PTPIP51 with 14-3-3beta and Raf-1 (show RAF1 Proteins) in vivo and a tyrosine-dependent interaction profile with DAGKalpha and PKA.
In glioblastoma PTPIP51 expression increases with the grade of malignancy and PTPIP51 interacts in situ with 14-3-3ss and PTP1B (show PTPN1 Proteins).
PTPIP51 is phosphorylated by Lyn (show LYN Proteins) and c-Src (show SRC Proteins) kinases lacking dephosphorylation by PTP1B (show PTPN1 Proteins) in acute myeloid leukemia (show BCL11A Proteins).
PTPIP51 expression was restricted to myeloid precursor cells undergoing differentiation. In blood cells therefore, PTPIP51 expression is restricted to differentiating and mature neutrophil granulocytes.
PTPIP51 might be involved in the regulation of cellular processes associated with differentiation, movement, or cytoskeletal organization
PTPIP51 is a mitochondrial protein (show COX6B2 Proteins) with apoptosis-inducing function and that the N-terminal TM domain is required for both the correct targeting of the protein to mitochondria and its apoptotic functions.
PTPIP51 and PTP1B (show PTPN1 Proteins), play a role in differentiation and apoptosis of the cytotrophoblast and syncytiotrophoblast, respectively. Moreover, PTPIP51 may also serve as a cellular signaling partner in angiogenesis and vascular remodeling.
FAM82A2 is expressed in keratinocyte carcinoma and their surrounding stroma.
Protein interaction profile of PTPIP51 suggests a role in the memory formation in the hippocampus and cerebellum.
PTPIP51(protein tyrosine phosphatase interacting protein 51) might serve as a linking protein in adipocyte metabolism by connecting the insulin receptor (show INSR Proteins)-triggered lipogenesis with the protein kinase A-dependent lipolysis.
The interaction of PTPIP51 with 14-3-3beta, especially in trained individuals, hints to an involvement of PTPIP51 in the downstream regulation of insulin (show INS Proteins) action.
The data presented here suggest a role of PTPIP51 in neuronal homeostasis, axonal growth, and transport.
The PTPIP51 was integrated in signaling cascades regulating differentiation and apoptosis during eye development.
Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity).
family with sequence similarity 82, member A2
, family with sequence similarity 82, member C
, regulator of microtubule dynamics protein 3
, Protein FAM82C
, TCPTP-interacting protein 51
, cerebral protein 10
, microtubule-associated protein
, protein tyrosine phosphatase-interacting protein 51
, tyrosine phosphatase interacting protein 51