Fanconi Anemia, Complementation Group D2 (FANCD2) ELISA Kits

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Additionally we are shipping FANCD2 Antibodies (141) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FANCD2 2177 Q9BXW9
FANCD2 211651 Q80V62
FANCD2 312641 Q6IV68
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Top FANCD2 ELISA Kits at antibodies-online.com

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Human
96 Tests Log in to see 2 to 3 Days
$480.00
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$430.50
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Human
96 Tests Log in to see 15 to 18 Days
$875.60
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Mouse
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$875.60
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Rat
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$619.29
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Top referenced FANCD2 ELISA Kits

  1. ABIN411657 : Wang, Wang, Qi: Identification of riboflavin: revealing different metabolic characteristics between Escherichia coli BL21(DE3) and MG1655. in FEMS microbiology letters 2015 (PubMed)
    Show all 2 references for 411657

More ELISA Kits for FANCD2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Fanconi Anemia, Complementation Group D2 (FANCD2) interaction partners

  1. FANCD2 acts independently of previous S phases to promote alignment and segregation of acentric DNA produced by double-strand breaks.

  2. Fancd2 has a role in DNA repair.

Xenopus laevis Fanconi Anemia, Complementation Group D2 (FANCD2) interaction partners

  1. study showed that FANCI (show FANCI ELISA Kits)-FANCD2 is required for replication-coupled DNA interstrand cross-link (ICL) repair in S phase; results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia (show PALB2 ELISA Kits) pathway is compromised

  2. The Fanconi anemia protein FANCM (show FANCM ELISA Kits) is controlled by FANCD2 and the ATR (show ATR ELISA Kits)/ATM (show ATM ELISA Kits) pathways.

Silk Worm Fanconi Anemia, Complementation Group D2 (FANCD2) interaction partners

  1. silkworm cells deficient for FA proteins FancD2 and FancM (show FANCM ELISA Kits) exhibit normal sensitivities to hydroxyurea (HU) and camptothecin (CPT (show DHDDS ELISA Kits))

  2. It was shown that silkworm FancD2 is monoubiquitinated depending on FancI (show FANCI ELISA Kits) and FancL (show FANCL ELISA Kits), and stabilized on chromatin, following mitomycin C. Depletion of FancD2, FancI (show FANCI ELISA Kits) or FancL (show FANCL ELISA Kits) effected cell proliferation in the presence of mitomycin C.

Human Fanconi Anemia, Complementation Group D2 (FANCD2) interaction partners

  1. The data demonstrate that FANCD2 protein is required to ensure efficient chromosome fragile sites (CFS) replication and provide mechanistic insight into how FANCD2 regulates CFS stability.

  2. A breakdown in a BRCA/FANCD2/BRG1 (show SMARCA4 ELISA Kits)/SNF (show SNRPA ELISA Kits)-DeltaNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells may contribute to sporadic breast cancer development.

  3. High FANCD2 expression is associated with drug Resistance in Malignant Melanoma.

  4. study demonstrates that Fanconi anemia (show PALB2 ELISA Kits) pathway component FANCD2 is recruited to HPV DNA, associates with members of the ATM (show ATM ELISA Kits) DNA repair pathway, and is essential for the maintenance of viral episomes in basal epithelial cells

  5. in Alternative Lengthening of Telomeres cells, FANCD2 promotes intramolecular resolution of stalled replication forks in telomeric DNA while BLM facilitates their resection and subsequent involvement in the intermolecular exchanges that drive Alternative Lengthening of Telomeres.

  6. A new role of FANCD2 in limiting constitutive replication stress in BRCA2 (show BRCA2 ELISA Kits)-deficient cells, thereby affecting cell survival and treatment responses.

  7. Collectively, these findings indicate that FANCD2 plays a novel role in the negative regulation of ferroptosis. FANCD2 could represent an amenable target for the development of novel anticancer therapies aiming to reduce the side effects of ferroptosis inducers.

  8. In both patient and knockout cell lines reduced localisation of BLM to ultra fine DNA bridges and FANCD2 at foci linking bridges are observed. Overall, loss of RMI2 produces a partially active BLM complex with mild features of Bloom syndrome.

  9. FANCD2 may have a role in progression of hepatocellular carcinoma

  10. Alpha-spectrin (show SPTAN1 ELISA Kits) is critical for recruitment of non-ubiquitinated FANCD2 to sites of damage, which has an important role in the repair response and interstrand cross-link repair.

Mouse (Murine) Fanconi Anemia, Complementation Group D2 (FANCD2) interaction partners

  1. loss of Fancd2 yields significant defects to fetal liver hematopoiesis, particularly the HSC (show FUT1 ELISA Kits) population, which mimics key phenotypes from adult Fancd2 KO bone marrow independently of aging-accrued DNA damage.

  2. Data that suggest Usp1 (ubiquitin specific peptidase 1 (show USP1 ELISA Kits)) down-regulation by autocleavage is critical for Usp1 (show USP1 ELISA Kits) to exert role in DNA interstrand crosslink repair; Usp1 (show USP1 ELISA Kits) role is de-ubiquitination of Fancd2 and Pcna (proliferating cell nuclear antigen (show PCNA ELISA Kits)).

  3. recruitment of Fan1 (show FAN1 ELISA Kits) by ubiquitinated-Fancd2 is dispensable for DNA interstrand cross-links repair

  4. Results show that FANCD2 and ADH5 (show ADH5 ELISA Kits) protect hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage resulting from accumulation of endogenous formaldehyde.

  5. Combined deficiency of Foxo3a (show FOXO3 ELISA Kits) and Fancc (show FANCC ELISA Kits) or Fancd2 not only impairs the self-renewal capacity but also markedly increases the apoptosis of neural stem and progenitor cells (NSPCs), leading to defective neurogenesis.

  6. Data demonstrated that Fancd2 was required for nuclear retention of CA-FOXO3a (show FOXO3 ELISA Kits) and for maintaining hematopoietic repopulation of the HSCs.

  7. CD25 (show IL2RA ELISA Kits)(+)Foxp3 (show FOXP3 ELISA Kits)(+) Tregs of Fanca (show FANCA ELISA Kits)(-/-) or Fancd2(-/-) mice were less efficient in suppressing the production of GVHD-associated inflammatory cytokines.

  8. Fancd2-Ub activates the transcription of the tumor suppressor TAp63, thereby promoting cellular senescence and blocking skin tumorigenesis.

  9. Studies indicate that in Fancd2-Knockout mice, the formation of sex-cords and intraovarian tubules lead to the formation of tumours with multiple phenotypes including luteomas, papillary cysts and malignant carcinomas.

  10. the Fanconi anaemia DNA repair pathway counteracts acetaldehyde-induced genotoxicity in mice; Aldh2 (show ALDH2 ELISA Kits)(-/-)Fancd2(-/-) mice spontaneously develop acute leukaemia

FANCD2 Antigen Profile

Antigen Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.

Gene names and symbols associated with FANCD2

  • Fanconi anemia, complementation group D2 (FANCD2) antibody
  • CG17269 gene product from transcript CG17269-RA (Fancd2) antibody
  • Fanconi anemia, complementation group D2 (fancd2) antibody
  • Fanconi anemia, complementation group D2 (Fancd2) antibody
  • 2410150O07Rik antibody
  • AU015151 antibody
  • BB137857 antibody
  • CG17269 antibody
  • CG31192 antibody
  • CG31194 antibody
  • Dmel\\CG17269 antibody
  • dmFANCD2 antibody
  • FA-D2 antibody
  • FA4 antibody
  • FACD antibody
  • FAD antibody
  • FAD2 antibody
  • FANCD antibody
  • FANCD2 antibody
  • xfancd2 antibody

Protein level used designations for FANCD2

Fanconi anemia, complementation group D2 , CG17269-PA , Fancd2-PA , Fanconi anemia group D2 protein-like , fanconi anemia protein FANCD2 , Fanconi anemia complementation group D2 , Fanconi anemia group D2 protein , Fanconi anemia group D2 protein homolog , Fanconi anemia D2 protein

GENE ID SPECIES
460163 Pan troglodytes
2768674 Drosophila melanogaster
100024226 Monodelphis domestica
100051871 Equus caballus
100455970 Pongo abelii
100469116 Ailuropoda melanoleuca
100487938 Xenopus (Silurana) tropicalis
100546871 Meleagris gallopavo
100560437 Anolis carolinensis
394241 Danio rerio
415935 Gallus gallus
734196 Xenopus laevis
100346581 Oryctolagus cuniculus
100620065 Bombyx mori
2177 Homo sapiens
211651 Mus musculus
312641 Rattus norvegicus
484659 Canis lupus familiaris
100522343 Sus scrofa
515845 Bos taurus
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