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Fanconi Anemia Complementation Group I (FANCI) ELISA Kits

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Additionally we are shipping FANCI Antibodies (21) and FANCI Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FANCI 55215 Q9NVI1
FANCI 208836 Q8K368
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Top FANCI ELISA Kits at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Mouse
96 Tests Log in to see 11 to 13 Days
$875.60
Details
Human
96 Tests Log in to see 11 to 13 Days
$875.60
Details

More ELISA Kits for FANCI Interaction Partners

Human Fanconi Anemia Complementation Group I (FANCI) interaction partners

  1. FANCI mutations are associated with Fanconi anemia (show PALB2 ELISA Kits) in VACTERL association.

  2. FANCJ (show BRIP1 ELISA Kits) protein is important for the stability of FANCD2 (show FANCD2 ELISA Kits)/FANCI proteins and protects them from proteasome and caspase-3 (show CASP3 ELISA Kits) dependent degradation.

  3. These findings indicate that FANCI functions upstream of FA core complex recruitment independently of FANCD2 (show FANCD2 ELISA Kits), and alter the current view of the FA-BRCA pathway.

  4. these purification methods for human FANCI and FANCD2 (show FANCD2 ELISA Kits) provide novel procedures to facilitate structural and biochemical studies of human FANCI and FANCD2 (show FANCD2 ELISA Kits).

  5. Results show that ATR (show ANTXR1 ELISA Kits)-mediated phosphorylation of FANCI, controls dormant origin firing in response to DNA replication stress.

  6. Our studies reveal a previously unknown mechanism for the coordinate nuclear import of a subset of FANCD2 and FANCI, a key early step in the cellular ICL response.

  7. Mutations in FANCI that impair its DNA binding activity compromise DNA-stimulated FANCD2 (show FANCD2 ELISA Kits) monoubiquitination.

  8. A CUE ubiquitin-binding domain in the FANCD2 (show FANCD2 ELISA Kits) protein is required for interaction with FANCI, retention of monoubiquitinated FANCD2 (show FANCD2 ELISA Kits), and FANCI in chromatin, and for efficient DNA interstrand crosslinks repair.

  9. These data suggest a key role for the E3 ligase activity of RAD18 (show RAD18 ELISA Kits) in the recruitment of FANCD2 (show FANCD2 ELISA Kits) and FANCI to chromatin and the events leading to their ubiquitylation during S phase.

  10. although proper nuclear localization of FANCI is crucial for robust FANCD2 (show FANCD2 ELISA Kits) monoubiquitination, the putative FANCI EDGE motif is important for DNA crosslink repair

Mouse (Murine) Fanconi Anemia Complementation Group I (FANCI) interaction partners

  1. crystal structure of FANCI-FANCD2 (show FANCD2 ELISA Kits)(ID) complex; crystallographic electron-density map of FANCI protein bound to splayed Y DNA; data suggest ID complex recognizes DNA structures resulting from encounter of replication forks with an interstrand cross-link

FANCI Antigen Profile

Antigen Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms.

Gene names and symbols associated with FANCI

  • Fanconi anemia, complementation group I (FANCI) antibody
  • Fanconi anemia, complementation group I (Fanci) antibody
  • KIAA1794 antibody

Protein level used designations for FANCI

Fanconi anemia group I protein , Fanconi anemia group I protein homolog

GENE ID SPECIES
55215 Homo sapiens
208836 Mus musculus
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