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Fanconi Anemia Complementation Group I Proteins (FANCI)

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Additionally we are shipping FANCI Antibodies (21) and FANCI Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FANCI 55215 Q9NVI1
FANCI 208836 Q8K368
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Top FANCI Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

FANCI Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Fanconi Anemia Complementation Group I (FANCI) Interaction Partners

Human Fanconi Anemia Complementation Group I (FANCI) interaction partners

  1. FANCI mutations are associated with Fanconi anemia (show PALB2 Proteins) in VACTERL association.

  2. FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 (show CASP3 Proteins) dependent degradation.

  3. These findings indicate that FANCI functions upstream of FA core complex recruitment independently of FANCD2, and alter the current view of the FA-BRCA pathway.

  4. these purification methods for human FANCI and FANCD2 provide novel procedures to facilitate structural and biochemical studies of human FANCI and FANCD2.

  5. Results show that ATR (show ANTXR1 Proteins)-mediated phosphorylation of FANCI, controls dormant origin firing in response to DNA replication stress.

  6. Our studies reveal a previously unknown mechanism for the coordinate nuclear import of a subset of FANCD2 and FANCI, a key early step in the cellular ICL response.

  7. Mutations in FANCI that impair its DNA binding activity compromise DNA-stimulated FANCD2 monoubiquitination.

  8. A CUE ubiquitin-binding domain in the FANCD2 protein is required for interaction with FANCI, retention of monoubiquitinated FANCD2, and FANCI in chromatin, and for efficient DNA interstrand crosslinks repair.

  9. These data suggest a key role for the E3 ligase activity of RAD18 (show RAD18 Proteins) in the recruitment of FANCD2 and FANCI to chromatin and the events leading to their ubiquitylation during S phase.

  10. although proper nuclear localization of FANCI is crucial for robust FANCD2 monoubiquitination, the putative FANCI EDGE motif is important for DNA crosslink repair

Mouse (Murine) Fanconi Anemia Complementation Group I (FANCI) interaction partners

  1. crystal structure of FANCI-FANCD2(ID) complex; crystallographic electron-density map of FANCI protein bound to splayed Y DNA; data suggest ID complex recognizes DNA structures resulting from encounter of replication forks with an interstrand cross-link

FANCI Protein Profile

Protein Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms.

Gene names and symbols associated with FANCI

  • Fanconi anemia, complementation group I (FANCI)
  • Fanconi anemia, complementation group I (Fanci)
  • KIAA1794 protein

Protein level used designations for FANCI

Fanconi anemia group I protein , Fanconi anemia group I protein homolog

GENE ID SPECIES
55215 Homo sapiens
208836 Mus musculus
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