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The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Additionally we are shipping FANCM Kits (2) and and many more products for this protein.
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we provide evidence for the first time showing that the common p.Arg1931* loss-of-function variant in FANCM is a risk factor for familial breast cancer.
FANCM c.5101C>T mutation was not identified in Pakistani triple-negative breast cancer patients
MHF facilitates the processing of multiple types of branched DNAs by the DNA translocase FANCM. MHF complex recognizes branched DNA and stimulates FANCM activity at such a structure to promote genome maintenance.
FANCM is a breast cancer susceptibility gene, mutations in which confer a particularly strong predisposition for triple-negative breast cancer
The MHF complex, which is a heterotetramer that comprises two MHF1 (show APITD1 Antibodies)-MHF2 heterodimers, is remodeled by FANCM to favor recognition of branched DNA over dsDNA.
The FANCM translocase domain lies in proximity to C-terminal domain and binding fork DNA structures stimulate its ATPase (show DNAH8 Antibodies) activity.
The traverse frequency was strongly reduced by inactivation of the translocase and DNA binding activities of the FANCM/MHF complex.
Variations of several key residues and the electrostatic property at the active-site region render a catalytically inactive nuclease (show DCLRE1C Antibodies) domain of FANCM, accounting for the lack of nuclease (show DCLRE1C Antibodies) activity.
Genotoxic stress-induced FANCM phosphorylation is ATR-dependent.
FANCM participates in recombination-independent interstrand crosslink repair by facilitating recruitment of lesion incision activities, which requires its translocase activity
Fancm(Delta2/Delta2) mice also showed unique features atypical for Fanconi anemia (show PALB2 Antibodies) mice, including underrepresentation of female Fancm(Delta2/Delta2) mice and decreased overall and tumor-free survival.
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M.
Fanconi anemia complementation group M
, fanconi anemia complementation group M
, ATP-dependent RNA helicase FANCM
, Fanconi anemia group M protein
, fanconi anemia-associated polypeptide of 250 kDa
, protein Hef ortholog
, Fanconi anemia group M protein homolog