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Fanconi Anemia Group A Protein Proteins (FANCA)

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Additionally we are shipping Fanconi Anemia Group A Protein Antibodies (104) and Fanconi Anemia Group A Protein Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FANCA 2175 O15360
FANCA 14087 Q9JL70
Rat FANCA FANCA 361435  
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Top Fanconi Anemia Group A Protein Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

FANCA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Fanconi Anemia Group A Protein (FANCA) Interaction Partners

Human Fanconi Anemia Group A Protein (FANCA) interaction partners

  1. Using human and murine cells defective in FANCD2 or FANCA and primary bone marrow cells derived from FANCD2 deficient mice, we show that the FA pathway removes R loops and that many DNA breaks accumulated in FA cells are R loop-dependent.

  2. FANCA safeguards interphase and mitosis during hematopoiesis

  3. The I939S point mutation prevented binding to the FAAP20 subunit of the FA core complex, caused SUMOylation at K921, RNF4 (show RNF4 Proteins)-mediated polyubiquitination and degradation.

  4. A frameshifting mutation and a truncating mutation of FANCA are associated with Fanconi anemia (show PALB2 Proteins).

  5. Proliferation is compromised in FANCA-deficient pluripotent embryonic stem cells.

  6. FANCA-modulated neddylation pathway involved in CXCR5 (show CXCR5 Proteins) membrane targeting and cell mobility.

  7. BRCA2 (show BRCA2 Proteins) rs10492396 (AG vs. GG: adjusted hazard ratio (adjHR)=1.85, 95% confidence interval (CI)=1.16-2.95, P=0.010), rs206118 (CC vs. TT+TC: adjHR=2.44, 95% CI=1.27-4.67, P=0.007), rs3752447 and FANCA rs62068372

  8. Results suggest that the nonsynonymous single nucleotide polymorphism (rs2239359) in the FANCA gene or other causal variations coexisting with the GGGAGG haplotype may increase risk of premature ovarian failure in Korean women.

  9. Human Fanconi anemia complementation group a protein stimulates the 5' flap (show ALOX5AP Proteins) endonuclease activity of FEN1 (show FEN1 Proteins).

  10. c.190-256_283 + 1680del2040 dupC mutation in the FANCA gene is a founder mutation in Macedonian Fanconi anemia (show PALB2 Proteins) patients of Gypsy-like ethnic origin.

Mouse (Murine) Fanconi Anemia Group A Protein (FANCA) interaction partners

  1. FANCA safeguards interphase and mitosis during hematopoiesis

  2. study indicates that Fanca expression during endomitosis is crucial for normal megakaryopoiesis and platelet production.

  3. Data show that Fanconi anemia complementation group A Fanca is required for the induction of transition mutations at A/T residues during somatic hypermutation (SHM (show CNTNAP1 Proteins)) and immunoglobulin (Ig) class switch recombination (CSR (show SCARA3 Proteins)).

  4. CD25(+)Foxp3(+) Tregs of Fanca(-/-) or Fancd2(-/-) mice were less efficient in suppressing the production of GVHD-associated inflammatory cytokines.

  5. null mutations in Fanca or Fancg (show FANCG Proteins) are fully epistatic

  6. genetic diversity in FANCA, FANCC (show FANCC Proteins) and FANCL (show FANCL Proteins) does not support an association of these genes with cervical cancer susceptibility in the Swedish population.

  7. The results support a model where both FANCA and FANCC (show FANCC Proteins) are part of a multi-protein nuclear FA complex with identical function in cellular responses to DNA damage and germ cell survival.

  8. To study the in vivo role of the FA group A gene (Fanca), gene-targeting techniques were used to generate Fanca(tm1Hsc) mice in which Fanca exons 1-6 were replaced by a beta (show SUCLA2 Proteins)-galactosidase (show GLB1 Proteins) reporter construct.

  9. GnRH (show GNRH1 Proteins) induced a rapid, transient increase in Fanca mRNA.

  10. Fanca protein as an integral component in the early step of homologous repair of DNA double-strand brearks thereby minimizing the genomic instability.

Fanconi Anemia Group A Protein (FANCA) Protein Profile

Protein Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.

Gene names and symbols associated with FANCA

  • Fanconi anemia, complementation group A (FANCA)
  • Fanconi anemia, complementation group A (Fanca)
  • AW208693 protein
  • FA protein
  • FA-H protein
  • FA1 protein
  • FAA protein
  • FACA protein
  • FAH protein
  • FANCH protein

Protein level used designations for FANCA

Fanconi anemia group A protein , Fanconi anemia, complementation group H , Fanconi anemia, type 1 , Fanconi anemia group A protein homolog

GENE ID SPECIES
2175 Homo sapiens
454393 Pan troglodytes
14087 Mus musculus
415854 Gallus gallus
361435 Rattus norvegicus
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