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Farnesyl Diphosphate Synthase Proteins (FDPS)

FDPS encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. Additionally we are shipping FDPS Antibodies (94) and FDPS Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FDPS 2224 P14324
FDPS 83791 P05369
FDPS 110196 Q920E5
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Top FDPS Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast REACT_Maize/Corn His tag   1 mg Log in to see 56 to 66 Days
$2,951.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,960.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,960.83
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,004.83
Details

FDPS Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced FDPS Proteins

  1. Human FDPS Protein expressed in Escherichia coli (E. coli) - ABIN2005592 : Pjetursson, Brägger, Lang, Zwahlen: Comparison of survival and complication rates of tooth-supported fixed dental prostheses (FDPs) and implant-supported FDPs and single crowns (SCs). in Clinical oral implants research 2007 (PubMed)
    Show all 2 references for ABIN2005592

  2. Mouse (Murine) FDPS Protein expressed in Escherichia coli (E. coli) - ABIN2008751 : Moshage, Princen, van Pelt, Roelofs, Nieuwenhuizen, Yap et al.: Differential effects of endotoxin and fibrinogen degradation products (FDPS) on liver synthesis of fibrinogen and albumin: evidence for the involvement of a novel monokine in the stimulation of ... in The International journal of biochemistry 1991 (PubMed)
    Show all 2 references for ABIN2008751

More Proteins for Farnesyl Diphosphate Synthase (FDPS) Interaction Partners

Fruit Fly (Drosophila melanogaster) Farnesyl Diphosphate Synthase (FDPS) interaction partners

  1. mitochondrial targeting of FPS may be widespread among eukaryotes

  2. Farnesyl diphosphate synthase (FPPS) of the dipteran Drosophila melanogaster has been cloned and its catalytic properties have been assessed.

Human Farnesyl Diphosphate Synthase (FDPS) interaction partners

  1. These results are consistent with the previously proposed hypothesis that the allosteric pocket of human FPPS, located near the active site, plays a feed-back regulatory role for this enzyme.

  2. our study indicated that DR patients have higher VEGF levels than diabetic patients without retinopathy, and -2578A/C (rs699947) and +405C/G (rs2010963) may be important factors in determining serum VEGF levels.

  3. Results suggest that polymorphisms of the FDPS gene may influence the bone response to drugs targeting the mevalonate pathway, like statins.

  4. A co-crystal structure of human farnesyl pyrophosphate synthase in complex with a bisphosphonate and two molecules of inorganic phosphate.

  5. The results identify new classes of FPPS inhibitors, diterpenoids and sesquiterpenoids, that bind to the IPP (show IPP Proteins) site and may be of interest as anticancer and antiinfective drug leads.

  6. These observations suggest that an increase in the expression of endogenous FPPS could confer at least partial resistance to the pharmacological effect of N-BP drugs such as ZOL in vivo

  7. LRP5 (show LRP5 Proteins) and FDPS loci age-specifically affect skeletal traits in healthy fertile women.

  8. Data indicate compounds represent a new structural class of farnesyl pyrophosphate synthase (hFPPS) inhibitors and suggest a development of therapeutics.

  9. The iPA-driven modulation of FDPS can cause an enhancement of post-translational prenylation essential for the biological activity of key proteins in NK signaling and effector functions, such as Ras.

  10. FPPS was more highly expressed in prostate cancer vs. normal prostate tissue. The association of FPPS with established histopathological risk parameters and biochemical recurrence implicates a contribution of the mevalonate pathway to PC progression.

Mouse (Murine) Farnesyl Diphosphate Synthase (FDPS) interaction partners

  1. Farnesyl pyrophosphate synthase (FPPS) may function as a potent regulator in myocardial remodelling. The FPPS-regulated signalling pathway is relevant to the pathological changes in cardiac hypertrophy and heart failure.

  2. identified a single putative direct repeat 4 (DR4 (show HLADRB4 Proteins)) LXR (show NR1H3 Proteins) response element in the FPS (show FES Proteins) promoter isolated from immortalized murine astrocyte P11 (show S100A10 Proteins)-5 cells

FDPS Protein Profile

Protein Summary

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with FDPS

  • Farnesyl pyrophosphate synthase (Fpps)
  • farnesyl diphosphate synthase (fdps)
  • farnesyl pyrophosphate synthetase (MGG_08649)
  • farnesyl pyrophosphate synthetase (TP03_0857)
  • farnesyl pyrophosphate synthetase (Tb09.160.4300)
  • farnesyl pyrophosphate synthetase (NCU01175)
  • farnesyl pyrophosphate synthetase (BBOV_I000120)
  • FDP synthase (fps)
  • Farnesyl pyrophosphate synthetase (fpps)
  • farnesyl diphosphate synthase (FDPS)
  • farnesyl diphosphate synthase (Fdps)
  • farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) (FDPS)
  • farnesyl diphosphate synthetase (Fdps)
  • farnesyl pyrophosphate synthase1 (fps1)
  • (2E protein
  • 16.m00760 protein
  • 6030492I17Rik protein
  • Ac2-125 protein
  • AI256750 protein
  • CG12389 protein
  • DDBDRAFT_0206220 protein
  • DDBDRAFT_0215017 protein
  • DDB_0206220 protein
  • DDB_0215017 protein
  • Dmel\\CG12389 protein
  • DmFPPS protein
  • DmFPPSase protein
  • DmFPS protein
  • Fdpsl1 protein
  • FPPS protein
  • fps protein
  • l(2)k06103 protein
  • mKIAA1293 protein
  • NCU01175.1 protein
  • v(2)k03514 protein

Protein level used designations for FDPS

farnesyl pyrophosphate synthase , CG12389-PA , Fpps-PA , farnesyl diphosphate synthase , farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) , farnesyl pyrophosphate synthetase , Farnesyl pyrophosphate synthetase , (2E,6E)-farnesyl diphosphate synthase , FPP synthase , FPP synthetase , dimethylallyltranstransferase , farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase , geranyltranstransferase , CR 39 , cholesterol-regulated 39 kDa protein , farnesyl diphosphate synthetase , testis-specific farnesyl pyrophosphate synthetase , FPS , 6E)-farnesyl diphosphate synthase , FPPS , GRMZM2G168681 , PCO074380 , PCO074380(592) , PCO074380_ov , PCO074380b , QBB18h08 , geranylgeranyl-diphosphate synthase , gnp_QBB18h08b , gpm430b , prenyltransferase

GENE ID SPECIES
36209 Drosophila melanogaster
548584 Xenopus (Silurana) tropicalis
735190 Xenopus laevis
2678891 Magnaporthe oryzae 70-15
3499793 Theileria parva strain Muguga
3660082 Trypanosoma brucei brucei strain 927/4 GUTat10.1
3877737 Neurospora crassa OR74A
5476865 Babesia bovis T2Bo
8621722 Dictyostelium discoideum AX4
100195349 Salmo salar
2224 Homo sapiens
83791 Rattus norvegicus
281156 Bos taurus
480129 Canis lupus familiaris
425061 Gallus gallus
110196 Mus musculus
541903 Zea mays
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