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The protein encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. Additionally we are shipping FCGR2B Kits (26) and FCGR2B Proteins (23) and many more products for this protein.
Showing 10 out of 82 products:
Human Polyclonal FCGR2B Primary Antibody for WB - ABIN657908
Prokopec, Rhodiner, Matt, Lindqvist, Kleinau: Down regulation of Fc and complement receptors on B cells in rheumatoid arthritis. in Clinical immunology (Orlando, Fla.) 2010
Show all 4 references for ABIN657908
Human Polyclonal FCGR2B Primary Antibody for IHC, ELISA - ABIN185377
McGaha, Sorrentino, Ravetch: Restoration of tolerance in lupus by targeted inhibitory receptor expression. in Science (New York, N.Y.) 2005
Show all 2 references for ABIN185377
Human Polyclonal FCGR2B Primary Antibody for IHC (p), WB - ABIN515564
Smith, Wietgrefe, Shang, Reilly, Southern, Perkey, Duan, Kohler, Müller, Robinson, Carlis, Li, Johnson, Haase: Live simian immunodeficiency virus vaccine correlate of protection: immune complex-inhibitory Fc receptor interactions that reduce target cell availability. in Journal of immunology (Baltimore, Md. : 1950) 2014
Fc-gamma receptor (show FCGR1A Antibodies) polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis.
LPS (show IRF6 Antibodies) activation of TLR4 (show TLR4 Antibodies) significantly increased MARCH3 (show MARCH3 Antibodies) expression and that siRNA against MARCH3 (show MARCH3 Antibodies) prevented the decrease in FcgammaRIIb following LPS (show IRF6 Antibodies) treatment.
a rare FCGR2B null-variant allele was found, in which a polymorphic stop codon of FCGR2C is introduced into one FCGR2B gene
FcgammaRIIB requires Btk (show BTK Antibodies) and p38 MAPK (show MAPK14 Antibodies) to mediate antigen-independent inhibition in human B cells.
The FCGR2B variant leads to reduced serum IL-6 (show IL6 Antibodies), later disease onset and reduced need for biological treatment, but does not seem to aggravate RA. The TM region variant is associated with a lower activation state of the Tregs and naive and memory B cells.
FcgIIb on GM-CSF (show CSF2 Antibodies) macrophages has a role in controlling immune complex-mediated inhibition of inflammatory signals
none of the three functional polymorphisms in FcgammaR genes explored here, the FCGR3A (show CD16 Antibodies) F158V and FCGR2B I232T nsSNPs and the VNTR in FCGRT (show FCGRT Antibodies), showed an association with the response to TNFi in patients with rheumatoid arthritis
Data show that the recombinant Fc gamma receptors FcgammaRIa (show FCGR1A Antibodies), FcgammaRIIa, FcgammaRIIb, FcgammaRIIIa(Phe158/Val158), and FcgammaRIIIb glycosylation is complex and varied between receptors.
FCGR2B inhibitory gene may be predictive of adjuvant trastuzumab benefit in HER2 (show ERBB2 Antibodies)+ breast cancer patients.
Data indicate that Fcgamma receptors FcgammaRIIb and FcgammaRIIa may play a structural role in augmenting CD20 (show MS4A1 Antibodies) internalization.
CD32 is a crucial regulator of FVIII (show F8 Antibodies)-specific B cells and is required for the differentiation of memory B cells into antibody-secreting cells.
Aggregated alpha-Synuclein (alpha-syn) inhibited microglial phagocytosis. The inhibitory effect of aggregated alpha-syn on microglial phagocytosis was due to the activation of SHP-1 and FcgammaRIIB on microglia.
Fcgr2b(-/-) mice lose bone upon the onset of a hypergammaglobulinemia or the administration of IgG1 immune complexes.
IgG (FcgammaR) IIb is involved in the suppressive effect of immune complex on TLR9 (show TLR9 Antibodies)-mediated CD40 (show CD40 Antibodies), CD80 (show CD80 Antibodies) and IL-6 (show IL6 Antibodies) expression.
these studies demonstrate for the first time the ability of FcgammaRIIB to regulate vaccine-induced IgA production and downmodulate immunity and protection.
This inhibitory receptor present on dendritic cells, neutrophils, and B cells has an important role in controlling anti-myeloperoxidase (show MPO Antibodies) autoimmunity and limiting pathological effector responses and glomerular disease.
Deletion of FcgammaRIIb/ApoE (show APOE Antibodies) induces an anti-inflammatory Treg/macrophage polarization that is atheroprotective.
Fcgamma-RII and Fcgamma-RIII might participate in the uptake and/or transport of IgG through the intestinal epithelia of adult mice.
Aging Siglec-G (show SIGLEC10 Antibodies)-deficient and Siglec-G (show SIGLEC10 Antibodies) 3/FcgammaRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis.
This study demonstrated that the activating FcgammaRs-mediated inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact nerve fibers) in GBS (show GNB5 Antibodies).
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
, Fc fragment of IgG, low affinity II, receptor for (CD32)
, Fc fragment of IgG, low affinity IIb, receptor for (CD32)
, Fc gamma RIIb
, fc-gamma RII-b
, igG Fc receptor II-b
, low affinity immunoglobulin gamma Fc region receptor II-b
, Fc fragment of IgG, low affinity IIb, receptor (CD32)
, Fc fragment of IgG, low affinity IIb, receptor
, IgG Fc gamma receptor II
, Fc gamma RIIB
, fc gamma receptor IIB
, fc-gamma RII
, igG Fc receptor II beta
, low affinity immunoglobulin gamma Fc region receptor II
, lymphocyte antigen 17