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Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Additionally we are shipping FERMT2 Proteins (4) and and many more products for this protein.
Showing 10 out of 62 products:
Human Monoclonal FERMT2 Primary Antibody for IF, ELISA - ABIN564761
Dowling, Vreede, Kim, Golden, Feldman: Kindlin-2 is required for myocyte elongation and is essential for myogenesis. in BMC cell biology 2008
These findings show that talin and kindlin cooperatively activate integrins leading to fibronectin (show FN1 Antibodies) binding and adhesion.
These studies uncover a previously unrecognized function for Kindlin-2 and a mechanism for regulation of the chondrocyte differentiation programme and chondrogenesis.
Taken together, our study suggests the suppressive roles of Kindlin-2 in the pathogenesis of colorectal carcinoma
Data suggest that kindlin-2 (Kind2/Fermt2) interacts with actin alpha 2 (Actn2 (show ACTN2 Antibodies)) and integrin beta 1 (Itgb1 (show ITGB1 Antibodies)) and co-localizes to cardiac sarcomere at Z-disc; knockdown of Kind2 leads to dissociation of Actn2 (show ACTN2 Antibodies) and Itgb1 (show ITGB1 Antibodies).
beta3/kindlin-2 interaction promotes outside-in alphaVbeta3 signaling selectively, with biological consequences in vivo [kindlin-2]
kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch downstream of focal adhesion kinase in the integrin outside-in signaling circuit controlling cell migration and proliferation
kindlin-2, through activating Ras and the downstream ERK1/2 (show MAPK1/3 Antibodies) and Akt (show AKT1 Antibodies) signaling pathways, plays an important role in regulating renal tubular epithelial-to-mesenchymal transition
C-terminal LIM (show PDLIM5 Antibodies) domains of migfilin (show FBLIM1 Antibodies) dictate its focal adhesion localization, and these domains mediate an interaction with kindlin in vitro and in cells, demonstrating that kindlin is important for normal migfilin (show FBLIM1 Antibodies) dynamics.
kindlin-2 regulates trafficking of endothelial cell surface enzymes that control platelet responses and hemostasis.
Kindlin-2 mediates activation of TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling and renal fibrosis.
The F0 domain of K2 binds actin.
data indicate that kindlin-2 promotes the invasiveness of prostate cancer cells largely through NF-kappaB (show NFKB1 Antibodies)-dependent upregulation of MMP-9 (show MMP9 Antibodies) and MMP-2 (show MMP2 Antibodies)
High kindlin-2 expression is associated with esophageal squamous cell carcinoma.
our findings suggested that Kindlin-2 was highly expressed in hepatocellular carcinoma tissues and was closely related to clinical progression. Kindlin-2 protein could be a potential biomarker for predicting poor prognosis of HCC (show FAM126A Antibodies) patients after surgery.
findings suggest that Src (show SRC Antibodies), Kindlin-2 and Migfilin (show FBLIM1 Antibodies) together constitute a positive feedback loop that controls Src (show SRC Antibodies) activity and regulates integrin-mediated cellular func
Data indicate that Kindlin-2 mRNA levels in adult is highly expressed in mesoderm-derived organs.
A major ILK (show ILK Antibodies) binding site in the kindlin-2 FERM domain for regulating cell adhesion has been mapped.
the first evidence that interaction between the integrin beta1 cytoplasmic tail and kindlin-2, a member of a family of adapters implicated in human disease pathogenesis, is mainly governed by the beta1 C-terminal carboxylate moiety
Kindlin-2 was highly expressed in the peritumoral stroma of pancreatic ductal adenocarcinomas. Stromal kindlin-2 expression was related to nodal metastasis (P = 0.03).
Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites (By similarity).
fermitin family homolog 2
, mitogen inducible 2
, pleckstrin homology domain containing, family C (with FERM domain) member 1
, pleckstrin homology domain-containing family C member 1
, PH domain-containing family C member 1
, kindlin 2
, mitogen inducible gene 2 protein
, mitogen-inducible gene 2 protein
, pleckstrin homology domain containing, family C member 1