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inhibits insulin receptor tyrosine kinase activity, protease inhibitory activities; developmentally regulates calcium metabolism and osteogenesis.
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Data indicate that fetuin-B was one of the highly expressed serum proteins in acute myocardial infarction.
Reduced expression of fetuin-b led to a significant increase in the expression of lipogenic genes, thereby resulting in higher lipid levels.
serum fetuin (show AHSG Antibodies) has a role in processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 (show BMP2 Antibodies) in cultured human vascular smooth muscle cells
results support the hypothesis that fetuin-A (show AHSG Antibodies) serum levels are associated with bone cell activity
Fetuin-B-deficient female mice are infertile due to an early block to fertilization.
Overexpression of Fetuin-B in skin squamous carcinoma cells led to suppression of tumor growth in nude mice.
The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells.
, fetuin-like protein IRL685
, fetuin beta
, fetuin phosphoprotein