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FIGLA encodes a protein that functions in postnatal oocyte-specific gene expression. Additionally we are shipping FIGLA Antibodies (24) and FIGLA Kits (2) and many more products for this protein.
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study identified an association between FIGLA gene variants and the occurrence of premature ovarian failure(POF (show POF1B Proteins)) in the Indian population; findings suggest that the c.427G->C and c.557C->T alleles lead to an increased risk of POF (show POF1B Proteins) in Indian women
These results suggest that FIGLA is involved in continued oocyte survival as primordial follicles form in the human as in the rodent ovary.
the p.140 delN mutation disrupted FIGLA binding to the TCF3 (show TCF3 Proteins) helix-loop-helix (HLH) domain. Our findings show that a subset of Chinese women with sporadic, premature ovarian failure harbor mutations in FIGLA.
GFP positive cells showed the expression of germ cell markers Vasa (show DDX4 Proteins), meiotic specific gene Stra8, Scp3 (show SYCP3 Proteins), oocyte markers Gdf9 (show GDF9 Proteins), Zp3 (show ZP3 Proteins) and Figla, indicating that this method could be used for the purification and selection of female germ cells
Data suggest that a dynamic DNA CpG methylation in Sohlh2 (show SOHLH2 Proteins) and Figlalpha promoters, but not in the intron and exon sequences, is linked to regulation of gene expression, even though CpG islands are also present in their introns or exons.
physiological expression of Figla plays a critical dual role in activation of oocyte-associated genes and repression of sperm-associated genes during normal postnatal oogenesis
FIGLA is a central regulator of oocyte-specific genes that play roles in folliculogenesis, fertilization and early development.
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6.
class C basic helix-loop-helix protein 8
, factor in the germline alpha
, folliculogenesis-specific basic helix-loop-helix protein
, transcription factor FIGa
, FIG alpha